Common variant within the FTO gene, rs9939609, obesity and type 2 diabetes in population of Karachi, Pakistan

Fawwad, Asher; Siddiqui, Iftikhar Ahmed; Basit, Abdul; Zeeshan, Nimra Fatima; Shahid, Syed Muhammad; Nawab, Syeda Nuzhat; Siddiqui, Sidra

doi:10.1016/j.dsx.2015.02.001

Cited by 21 publications

(14 citation statements)

References 27 publications

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“…For example, allele A of the rs9939609 polymorphism of the FTO gene was associated with greater accumulation of body fat, an increase in BMI, waist and hip circumference, blood pressure, triglycerides and low‐density lipoprotein cholesterol, and a further decrease in high‐density lipoprotein cholesterol (Dina et al, ; Frayling et al, ; Gerken et al, ; Liu et al, ; Reuter et al, ; Solak et al, ; Yang et al, ). However, other studies found no association between the FTO polymorphism and weight status (Fawwad et al, ; Solak et al, ), which is in agreement with the results of our study.…”

Section: Discussionsupporting

confidence: 94%

“…The frequencies of the major alleles of the ADIPOQ (control T: 0.924; case T: 0.872), and LEP (control G: 0.574; case G: 0.673) polymorphisms have been reported in other studies (Hinuy et al, ; Mackevics et al, ). The frequencies of the major allele of the FTO polymorphism observed here in the case (T: 0.700) and control (T: 0.705) groups were higher than those reported by other authors (da Silva et al, ; Fawwad et al, ). We believe that the small sample size of our study may be the reason for the higher frequencies.…”

Section: Discussioncontrasting

confidence: 77%

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Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants

Kroll

Mastroeni

Veugelers

et al. 2016

American J Hum Biol

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Section: Discussionsupporting

confidence: 94%

Section: Discussioncontrasting

confidence: 77%

Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants

Kroll

Mastroeni

Veugelers

et al. 2016

American J Hum Biol

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“…The existing literature also states that the various risk factors of erectile dysfunction are associated with penile arterial insufficiency, including hypertension, hyperlipidemia, cigarette smoking, and diabetes mellitus [13141516]. Such disorders are highly prevalent in our community [171819]. Moreover, a relatively large number of cases of arterial insufficiency have been reported by other researchers [2021].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Causes of Erectile Dysfunction in Patients Undergoing Penile Doppler Ultrasonography in Pakistan

Khanzada

Khan

Hussain

et al. 2017

World J Mens Health

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PurposeIn patients with erectile dysfunction, it is important to differentiate psychogenic from organic causes. Penile Doppler ultrasonography is a relatively inexpensive and minimally invasive tool for this purpose. This study was conducted to evaluate the causes of erectile dysfunction in an adult male population, using penile Doppler ultrasonography.Materials and MethodsA retrospective study was conducted in a single center. All patients who presented with complaints of erectile dysfunction and underwent penile Doppler ultrasonography between July 2014 and June 2016 were included in this study. All examinations were performed using GE Voluson S6 and GE Logiq P5 devices. Following baseline scans, an intracavernosal injection of 20 µg of prostaglandin E1 was given. Peak systolic and end diastolic velocities were measured in each cavernosal artery. Patients with a peak systolic velocity of <25 cm/s were considered to have arterial insufficiency, while an end diastolic velocity of >5 cm/s was considered to indicate venous incompetence.ResultsOut of 97 patients (mean age, 37.09±11.59 years; range, 19~69 years), 50 patients (51.5%) had normal findings, 24 patients (24.7%) had arterial insufficiency, 15 patients (15.5%) had a venous leak, and 8 patients (8.2%) patients had arterial insufficiency with a venous leak. Psychogenic erectile dysfunction was significantly higher among patients aged ≤40 years, while arterial insufficiency with or without a venous leak was significantly higher among patients aged >40 years (p=0.022).ConclusionsA majority of the studied individuals demonstrated no organic cause of erectile dysfunction, thus confirming a high prevalence of the psychogenic etiology, particularly in relatively young individuals.

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“…The association between FTO and BMI has also been reported in non-European inhabitants including South Asians (4)(5)(6). In a previous work, the correlation between FTO single nucleotide polymorphisms (SNPs) and obesity was found to be non-significant (7,8). However, it was found that translation of FTO SNPs accounts dissimilar variations in BMI (0.16-0.20%) in Asian populations than in Europeans (9).…”

Section: Introductionmentioning

confidence: 87%

“…Ethical approval was taken from the Institutional Review Board (IRB) of BIDE. The present study is based on a previously published case-control study that described the association of different FTO genes with T2DM; where TT represents a homozygous protective allele, AA is homozygous risk allele and AT is heterozygous allele (16). The basic clinical, demographic, and genetic data were taken from a previous study.…”

Section: Methodsmentioning

confidence: 99%

The Role of FTO Gene Alleles on the Diet and Metabolic Risk Factors in the Subjects with Diabetes

Fawwad¹,

Siddiqui²,

Shaheen³

et al. 2017

Turk J Endocrinol Metab

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. The present study is based on a previously published case-control study that indicates the association of different FTO gene with type 2 diabetes. The structured questionnaire was used to gather anthropometric, biochemical, and clinical data. Single nucleotide polymorphism (SNP) in FTO gene was analyzed using Amplication Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR). The nutritional data were collected using a 24-hour dietary recall questionnaire completed by a trained dietitian. The variations in energy and macronutrient intake of subjects having different FTO gene alleles were investigated and evaluated for correlations between energy and macronutrient intake and metabolic risk variables in three FTO-gene-allele groups. Results: Overall, 198 adult subjects with type 2 diabetes (T2D) were recruited and categorized into three genotype groups: TT, AA and AT with the mean age of 49.7 ±9.7, 49.3 ±10.6 and 50.2 ±8.8 years, respectively. A close association was observed between the minor allele A at rs9939609 and type 2 diabetes. A linear correlation was observed between diet and metabolic prole markers such as BMI, waist circumference, blood pressure, and lipid prole among high-risk alleles AA. The associations of energy intake and percent level of carbohydrate and protein intake with metabolic syndrome were signi-cantly higher among risk alleles AA (P<0.05). However, the majority of the biochemical parameters and dietary components were found to be statistically insignicant (p>0.05). Discussion: Genetic prole is likely to affect both dietary habits as well as the association between diet and metabolic syndrome markers. This study concludes that diet-disease associations are more prominent in individuals having risk alleles AA as compared to protective alleles TT and heterozygous alleles AT. Keywords: Diet, T2DM, FTO, nutrigenomicsAmaç: Farklı FTO gen alellerine sahip Tip 2 diyabetli bireylerde çeşitli gıda alımının metabolik risk belirteçleri üzerindeki etkisini değerlendirmek. Gereç ve Yöntemler: Çalışma, Mart 2011 ile Mayıs 2013 arasında Baqai Diabetoloji ve Endokrinoloji Enstitüsü (BIDE) Karachi, Pakistan'da gerçekleştirildi. Bu çalışma, farklı FTO genlerinin Tip 2 diyabet ile ilişkisini gösteren önceden yayımlanmış bir vaka kontrol çalışmasına dayanmaktadır. Antropometrik, biyokimyasal ve klinik verileri toplamak için yapılandırılmış anket kullanılmıştır. FTO genindeki tek nükleotid polimorzmi (SNP), Amplikasyon Refrakter Mutasyon Sistemi-Polimeraz Zincir Reaksiyonu (ARMS-PCR) kullanılarak analiz edildi. Beslenme verileri, eğitimli bir diyetisyen tarafından doldurulmuş 24 saatlik bir diyet hatırlatma anketi kullanılarak toplandı. Farklı FTO gen alellerine sahip bireylerin enerji ve makro besin alımındaki değişiklikler araştırıldı ve üç FTOgen-alel grubundaki enerji, makrobesin alımı ve metabolik risk değişkenleri arasındaki korelasyonlar açısından değerlendirildi. Bulgular: Genel olarak, Tip 2 diyabetli (T2D) 198 erişkin hasta çalışmaya alındı ve üç genotip grubuna ayrıldı: yaş ortal...

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Common variant within the FTO gene, rs9939609, obesity and type 2 diabetes in population of Karachi, Pakistan

Cited by 21 publications

References 27 publications

Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants

Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants

Evaluation of the Causes of Erectile Dysfunction in Patients Undergoing Penile Doppler Ultrasonography in Pakistan

The Role of FTO Gene Alleles on the Diet and Metabolic Risk Factors in the Subjects with Diabetes

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