Common uropathogens and their antibiotic susceptibility pattern among diabetic patients

Woldemariam, Hiwot Ketema; Geleta, Dereje Assefa; Tulu, Kassu Desta; Aber, Negga Asamene; Legese, Melese Hailu; Fenta, Genet Molla; Ali, Ibrahim

doi:10.1186/s12879-018-3669-5

Cited by 65 publications

(112 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All of the 20 studies included in this review were crosssectional by design. Most of the studies were reported from Amhara region (n = 8) [30][31][32][33][34][35][36][37] and Addis Ababa (n = 7) [38][39][40][41][42][43][44]. The remaining studies were from Oromia (n = 4) [45][46][47][48] and Southern nations (n = 1) [23].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Prevalence of Vancomycin resistant enterococci (VRE) in Ethiopia: a systematic review and meta-analysis

2020

View full text Add to dashboard Cite

Background: The emergence of Vancomycin resistant enterococci (VRE) poses a major public health problem since it was first reported. Although the rising rates of VRE infections are being reported elsewhere in the worldwide; there is limited national pooled data in Ethiopia. Therefore, this study was aimed to estimate the pooled prevalence of VRE and antimicrobial resistance profiles of enterococci in Ethiopia. Methods: Literature search was done at PubMed, EMBASE, Google scholar, African Journals online (AJOL) and Addis Ababa University repository following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Both published and unpublished studies reporting the prevalence of VRE until June 30, 2019 were included. Data were extracted using Microsoft Excel and copied to Comprehensive Meta-analysis (CMA 2.0) for analysis. Pooled estimate of VRE was computed using the random effects model and the 95% CIs. The level of heterogeneity was assessed using Cochran's Q and I 2 tests. Publication bias was checked by visual inspection of funnel plots and Begg's and/or Egger's test. Results: Twenty studies fulfilled the eligibility criteria and found with relevant data. A total of 831 enterococci and 71 VRE isolates were included in the analysis. The pooled prevalence of VRE was 14.8% (95% CI; 8.7-24.3; I 2 = 74.05%; P < 0.001). Compared to vancomycin resistance, enterococci had higher rate of resistance to Penicillin (60.7%), Amoxicillin (56.5%), Doxycycline (55.1%) and Tetracycline (53.7%). Relatively low rate of resistance was found for Daptomycin and Linezolid with a pooled estimate of 3.2% (95% CI, 0.5-19.7%) and 9.9% (95% CI, 2.8-29.0%); respectively. The overall pooled multidrug resistance (MDR) rate of enterococci was 60.0% (95% CI, 42.9-75.0%). Conclusion: The prevalence of VRE and drug resistant enterococci are on the rise in Ethiopia. Enterococcal isolates showed resistance to one or more of the commonly prescribed drugs in different or the same drug lines. Multidrug resistant (MDR) enterococci were also found. Although the rates were low, the emergence of resistance to Daptomycin and Linezolid is an alarm for searching new ways for the treatment and control of VRE infections. Adherence to antimicrobial stewardship, comprehensive testing and ongoing monitoring of VRE infections in the health care settings are required.

show abstract

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Prevalence of Vancomycin resistant enterococci (VRE) in Ethiopia: a systematic review and meta-analysis

2020

View full text Add to dashboard Cite

show abstract

“…Globally, it ranges from 12% to 40.2% and in Ethiopia its prevalence is between 10.9% and 22.6%. [14][15][16][17][18] Several uropathogens have been identified in diabetic patients and the most common uropathogens isolated are Escherichia coli, Klebsiella spp., and Staphylococcus aureus. 7,9,12,18 Due to different reasons, these bacterial uropathogens showed wide-ranging resistances to different classes of antibiotics across the world.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17][18] Several uropathogens have been identified in diabetic patients and the most common uropathogens isolated are Escherichia coli, Klebsiella spp., and Staphylococcus aureus. 7,9,12,18 Due to different reasons, these bacterial uropathogens showed wide-ranging resistances to different classes of antibiotics across the world. 6,7, In diabetic patients, early diagnosis of UTI is essential for its proper management and to avoid the incidence of possible complications.…”

Section: Introductionmentioning

confidence: 99%

<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

Alemu¹,

Belete²,

Gebre-Selassie³

et al. 2020

DMSO

View full text Add to dashboard Cite

Purpose: To determine the bacterial profile with its associated risk factors and to identify extended spectrum beta-lactamase producing Gram-negative bacterial uropathogens among diabetic patients at Dessie Referral Hospital, Northeastern Ethiopia. Materials and Methods: A hospital-based cross-sectional study was conducted from May to September 2018. A total of 336 diabetic patients were included using a simple random sampling technique. A structured questionnaire was used to collect socio-demographic and risk factor-related data. A 10-mL mid-stream urine specimen was collected and transported to the microbiology laboratory for culture, antimicrobial susceptibility testing, and detection of ESBL-producing bacteria. The data were entered into SPSS version 22, and descriptive statistics, bivariate and multivariate logistic regression analyses were performed. A p-value ≤0.05 with a 95% confidence interval was considered for statistical significance. Results: Among 336 diabetic patients, the overall prevalence of UTI was 11.6%. The predominant bacterial isolate was Escherichia coli 12/39 (30.8%), followed by Klebsiella pneumoniae 11/ 39 (28.2%) and coagulase-negative staphylococci 7/39 (17.9%). Gram-negative isolates showed 100% resistance to ampicillin, whereas Gram-positive isolates showed a high level of resistance to penicillin and tetracycline. Moreover, MDR was observed among 18 (46.2%) of the isolates and 2 of the isolated Gram-negative bacteria were ESBL producers. Being illiterate (AOR=7.226, 95% CI: (1.478, 35.340), p<0.015), having current symptoms of UTI (AOR = 2.702, 95% CI: (1.102, 6.624), p=0.030), and blood glucose level ≥126 mg/dl (AOR = 2.940, 95% CI: (1.080, 8.005), p=0.035) were significantly associated with the occurrence of bacterial UTI. Conclusion: The overall prevalence of significant bacteriuria (11.6%) in this study was comparable with some studies in Ethiopia and relatively lower than others. A moderately higher rate of resistance to the commonly used antimicrobial agents was noticed for both Gram-negative and Gram-positive isolates. Health information dissemination should be given about UTI, glycemic control, and habit of drug use for diabetes mellitus patients.

show abstract

“…Woldemariam et al, 2019 reported that S. aureus 100% sensitive to nitrofurantoin, however 100% resistance to ampicillin, trimethoprim/sulphamethoxazole, and penicillin. 31 Sertaç et al, 2018 isolated multidrug resistance Staphylococcus sp. from the ocular surface of patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of bacteriuria, candiduria and antibiotics susceptibility patterns among diabetic verses nondiabetic patients

El-Sherbiny

Elsaeed

Radwan

et al. 2020

Al-Azhar International Medical Journal

View full text Add to dashboard Cite

Aim of the work: Assessment of the microbial species from diabetic and nondiabetic illness and their antibiotics susceptibility patterns. Materials and Methods: Two hundred urine specimens were collected from illness in a duration period extending from July 2018 to July 20119 at Badr University Hospital-Helwan, Cairo, Egypt. Samples were collecting cultivated on MacConkey, blood agar, and Sabouraud dextrose media. The microbial isolates were identified by microbiological methods. The antibiotic sensitivity was evaluated by the VITEK 2 compact automatic system and disk diffusion method. Results: Only 120 samples exhibit growth with a prevalence rate of 60%, from total samples collected. The results revealed UTIs were found to be significantly higher in diabetic illness (79%) compared to nondiabetic illness (41%). One hundred and twenty microbial species were recovered from collected urine specimens (79 from diabetic and 41 nondiabetics). Pathogenic bacteria & Candida were represented with 96 isolates (80.0 %) and 24 isolates (20.0), respectively. Among the 96 bacterial isolates, Escherichia coli constituted, Escherichia coli (72.80%), Klebsiella pneumonia (22.88%), and Staphylococcus aureus (4.16%). Meropenem, imipenem, trimethoprim/ sulphamethoxazole, and norfloxacin highly effective antibiotics against E. coli and Klebsiella pneumonia while amoxicillin, erythromycin, and vancomycin low effective. Conclusion: Diabetes disease a remarkable factor that stimulates UTIs. Higher frequency resistance to antibiotics in this study renders its indecency for empirical treatment and development of new empirical treatment.

show abstract

Common uropathogens and their antibiotic susceptibility pattern among diabetic patients

Cited by 65 publications

References 15 publications

Prevalence of Vancomycin resistant enterococci (VRE) in Ethiopia: a systematic review and meta-analysis

Prevalence of Vancomycin resistant enterococci (VRE) in Ethiopia: a systematic review and meta-analysis

<p>Bacterial Profiles and Their Associated Factors of Urinary Tract Infection and Detection of Extended Spectrum Beta-Lactamase Producing Gram-Negative Uropathogens Among Patients with Diabetes Mellitus at Dessie Referral Hospital, Northeastern Ethiopia</p>

Prevalence of bacteriuria, candiduria and antibiotics susceptibility patterns among diabetic verses nondiabetic patients

Contact Info

Product

Resources

About