Common Deletion (CD) in mitochondrial DNA of irradiated rat heart

Siqueira, Raquel G.; Silva, Dayse A.; Melo, Luiz Dione Barbosa De; Carvalho, Elizeu Fagundes de; Ferreira-Machado, Samara Cristina; Almeida, Carlos Eduardo de

doi:10.1590/0001-37652014110912

Cited by 3 publications

(13 citation statements)

References 18 publications

(13 reference statements)

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“…This has far reaching effects on both intestinal microbiota and systemic immunity. Helminths (parasitic worms) evolved in concert with the earliest mammals 42 and have shaped our genomes 43 . Helminths also shape innate and adaptive immune responses 44 .…”

Section: Resultsmentioning

confidence: 99%

Innate Immunity in Disease

Elliott

Siddique

Weinstock

2014

Clinical Gastroenterology and Hepatology

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Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement in order to control commensals, thwart pathogens and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease. This review focuses on pattern recognition receptors and cells of the innate immune system important for intestinal function. Our improving knowledge pertaining to this important aspect of our immune response is opening potential important new therapeutic opportunities for the treatment of disease.

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Section: Resultsmentioning

confidence: 99%

Innate Immunity in Disease

Elliott

Siddique

Weinstock

2014

Clinical Gastroenterology and Hepatology

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“…Numerous studies have reported that deletions of mtDNA play a pivotal role in aging and impairment of various human organs, such as the heart, [21] brain, [15,22] skin, [5,23] cornea, [24] and skeletal muscle. [25] MtDNA deletions are abundant in cochlear tissue, which have been shown, including mtDNA 10422, 13162, 7663, 4989, 7436, 4989, and 4977 bp deletion.…”

Section: Discussionmentioning

confidence: 99%

Correlation between mitochondrial DNA 4977 bp deletion and presbycusis

Han

Zhou

et al. 2019

Medicine

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Objective: Researchers have evaluated the associations between mitochondrial DNA (mtDNA) 4977 bp deletion and presbycusis. This study aimed to assess the differences of mtDNA 4977 bp deletion between presbycusis patients and controls by conducting a meta-analysis of published studies. Methods: Databases, including PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched to collect case–control studies on the correlation between mitochondrial DNA 4977 bp deletion and presbycusis. The research findings of related articles were collected according to the inclusion criteria. Pooled odds ratios (ORs) and corresponding confidence intervals (CIs) were calculated. Meanwhile, subgroup analysis was performed to examine the source of heterogeneity. Revman 5.3 and Stata 12.0 software were used for data synthesis. Results : Eight English and Chinese studies were included in the meta-analysis, the results of which showed that mitochondrial DNA 4977 bp deletion could increase the risk of presbycusis (OR = 8.16, 95% CI: 3.51–18.99), and the difference was statistically significant ( P <. 01). Analysis of the polled OR showed the incidence of mtDNA 4977 bp deletion was 8.50 times higher in Asians with presbycusis than in the control group. And the OR in the studies of occidentals was 7.24. Sample source analysis was also performed with the sample source divided by temporal bone source and other sources (hair and blood). The OR was 4.18 and 22.36 for the temporal bone and other sources, respectively. Conclusion: Mitochondrial DNA 4977 bp deletion could increase the risk of presbycusis.

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Common Deletion (CD) in mitochondrial DNA of irradiated rat heart

Cited by 3 publications

References 18 publications

Innate Immunity in Disease

Innate Immunity in Disease

Correlation between mitochondrial DNA 4977 bp deletion and presbycusis

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