Committed Delinquent Boys

A psychopharmacologic experiment in a training school for delinquent boys: Methods, problems, findings.

“…IN AN EARLIER study at a training school for Negro delinquent boys, we had contrasted the impact of per phenazine, placebo and no treatment on disturbed behavior. 25 The untreated, con trol subjects displayed a steady increase in symptoms during the study period, whereas those who had received either placebo or perphenazine showed a sta tistically significant decline in symptoms. The only evidence for drug action was -------to be found in a difference between the perphenazine and placebo groups after treatment was discontinued; the placebo group maintained its improvement whereas the perphenazine group showed a posttreatment return of symptoms, a change that suggested a rebound from a previous undetected effect.…”

Improving metabolic parameters of antipsychotic child treatment (IMPACT) study: rationale, design, and methods

“…There are no modern, placebo-controlled, randomized trials of perphenazine in youth. The one published study [30] has too many methodological problems to be interpretable. Perphenazine was selected based on the CATIE study, an adult schizophrenia trial that compared perphenzine to olanzapine, quetiapine, and risperidone treatment [31].…”