volume 41, issue 3, P705-707 2012
DOI: 10.1093/ije/dys048
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Abstract: The commentary in this issue by Boffetta et al. 1 addresses a challenging problem: given that a genetic factor, G, and an environmental factor, E, might both influence risk of cancer, how can we systematically assess the accumulated published evidence for the existence of interaction between them? Most complex diseases, not just cancer, probably arise through a web of factors that are both genetic and environmental, so this question arises as one of central relevance to the epidemiological study of aetiology.…

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