Biochemical Pharmacology volume 78, issue 11, P1360-1365 2009 DOI: 10.1016/j.bcp.2009.06.108 View full text
Michael Williams

Abstract: Antipsychotics, the drugs used currently for the treatment of schizophrenia, produce their therapeutic effects via the blockade of dopamine receptors. These compounds are, however, limited in their therapeutic efficacy and have side effect liabilities that also limit their use. Agents that produce antipsychotic effects by enhancing NMDA receptor function represent a viable alternative to dopamine antagonists. D-serine, is the prototype of this approach acting as a positive allosteric modulator of the NMDA rece…

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