Commentary: Distribution of 5-HT1F Receptors in Monkey Vestibular and Trigeminal Ganglion Cells

Valença, Marcelo Moraes

doi:10.3389/fneur.2016.00234

Cited by 1 publication

(2 citation statements)

References 23 publications

(21 reference statements)

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“…3-5 5-hydroxy tryptamine (5-HT) is a kind of important humoral mediator and neurotransmitter, and studies have revealed that 5-HT is closely related to the occurrence and development of migraine. [6][7][8] In addition, the studies on many subtypes of 5-HT have found that 5-HT receptor 6 (5-HTR6) bears a close relationship with the occurrence of pain. [9][10][11] Therefore, in this project, the VM patients were enrolled from our department to detect the polymorphism of 5-HTR6 rs770963777 site with the TaqMan-MGB probe and explore the correlation of 5-HTR6 gene polymorphism with VM, hoping to provide a theoretical support for the genetic polymorphism of VM.…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of VM has not been clarified yet, and the studies of some scholars have suggested that its onset is characterized by familial aggregation and related to genetic inheritance . 5‐hydroxy tryptamine (5‐HT) is a kind of important humoral mediator and neurotransmitter, and studies have revealed that 5‐HT is closely related to the occurrence and development of migraine . In addition, the studies on many subtypes of 5‐HT have found that 5‐HT receptor 6 (5‐HTR6) bears a close relationship with the occurrence of pain .…”

Section: Introductionmentioning

confidence: 99%

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Correlation of 5‐HTR6 gene polymorphism with vestibular migraine

Qiu

Wang

et al. 2019

J Clin Lab AnalHas erratum 2020-6-22

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Objective To investigate the correlation of 5‐hydroxy tryptamine receptor 6 (5‐HTR6) gene polymorphism with vestibular migraine (VM). Methods A total of 92 VM patients were enrolled as the observation group, and 100 healthy people receiving physical examinations as the control group. Their general clinical information was collected, and the level of 5‐HT in plasma and the vestibular function test indexes were detected. Moreover, the polymorphism of 5‐HTR6 rs770963777 was detected with the TaqMan‐MGB probe. Results The observation group had a lower level of 5‐HT than the control group (P < .05), and the abnormality rates of the vestibular function tests, including the caloric test, head‐shaking test, and vestibular autorotation test, were obviously higher than those in the control group (P < .01). The comparisons showed that the distribution frequencies of the genotypes and alleles were different between the two groups (P < .05). According to the analysis of the genetic mode, there were differences in recessive and additive modes between the two groups (P < .05), but the dominant mode was not different between the two groups (P > .05). Conclusion The level of 5‐HT and the vestibular function test indexes can serve as the effective indicators for observing VM, and the polymorphism of 5‐HTR6 rs770963777 site is correlated with VM onset.

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