Comment on IgE responses to <i>Ascaris</i> and mite tropomyosins are risk factors for asthma

Takeuchi, Haruko; Khan, Azharul Islam; Hasan, Mohammad Imrul; Hawlader, Mohammad Delwer Hossain; Yunus, Mohammad; Zaman, Khalequz; Chowdhury, Hafizur Rahman; Takanashi, Sayaka; Wagatsuma, Yukiko; Iwata, Tadahisa

doi:10.1111/cea.12678

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Nakazawa et al reported that Ascaris lumbricoides antigens induced the production of antibodies crossreactive to mite antigens from Dermatophagoides farina , indicating that mast cell‐bound anti‐ Ascaris IgE on the airway surface produced in the infected individual might crossreact with the inhaled Dermatophagoides antigen present in the environment. Therefore, the coexposure to mite and Ascaris antigens might increase the risk of wheezing . Although we could not measure the total IgE, anti‐Dp IgE, anti‐ Ascaris IgE, or Th cytokines, it is natural that anti‐ Ascaris IgE increases in those individuals with current or past Ascaris infections.…”

Section: Discussionmentioning

confidence: 96%

Concurrent decreases in the prevalence of wheezing and Ascaris infection among 5‐year‐old children in rural Bangladesh and their regulatory T cell immunity after the implementation of a national deworming program

Takeuchi

Khan

Ahmad

et al. 2019

Immunity Inflam & Disease

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Introduction Epidemiological research on the prevalence of asthma and helminthic infections in various countries has led to the hypothesis that helminthic infections protect against asthma by suppressing the host's immune response. This study was conducted to elucidate whether decreased Ascaris infection following a national deworming program was associated with increased recurrent wheezing among rural Bangladeshi children and to test their anti‐inflammatory immunity. Methods This nested case‐control study was conducted from December 2015 to October 2016 in the rural service area of the International Centre for Diarrhoeal Disease Research, Bangladesh. Of the 1800 5–year old children randomly selected for the study, informed consent was obtained from the guardians of 1658 children. Data were collected using a semistructured questionnaire adopted from the International Study of Asthma and Allergies in Childhood and blood samples for the analysis of regulatory T (Treg) cell immune responses and the balance between Th1 and Th2 immunity in Ascaris infections. Results A total of 145 children were found to have wheezing, yielding a prevalence rate of 8.7%, which was significantly lower than the rate found in 2001 (16.2%, P < .001); Ascaris infection also decreased from 2001 to 2016. The 127 wheezing children who agreed to participate further were compared to 114 randomly selected never‐wheezing children. Wheezing had a significant positive association with antibiotic use, history of pneumonia, parents’ history of asthma, and Ascaris infection; children with Ascaris infection were twice as likely to have wheezing (adjusted odds ratio = 2.31, P = .053). Flow cytometry found no significant differences in the rates of Th1, Th2, and CD4 +CD25 +CD127low cells by the wheezing group. Conclusions Ascaris infection had a positive rather than a negative association with wheezing and the rates of wheezing and Ascaris infections both decreased from 2001 to 2016. These findings undermines the hypothesis that such infections provide protection against asthma.

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Section: Discussionmentioning

confidence: 96%

Concurrent decreases in the prevalence of wheezing and Ascaris infection among 5‐year‐old children in rural Bangladesh and their regulatory T cell immunity after the implementation of a national deworming program

Takeuchi

Khan

Ahmad

et al. 2019

Immunity Inflam & Disease

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“… 40 These are higher than the estimates reported here; however, an asthma prevalence of 8.7% in 5 years from the same surveillance site was also reported, similar to the prevalence we report here. 41 These differences in prevalence could be due to environmental variation between the research sites within the country. Wide variations were seen between Indian centres from the ISAAC Phase 3 study which reported prevalence ranging from 4.6% to 45.7% for rhinitis and 0.9% to 9.2% for eczema among 13–14 years.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of atopic dermatitis, asthma and rhinitis from infancy through adulthood in rural Bangladesh: a population-based, cross-sectional survey

2020

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ObjectiveDescribe the pattern of atopic disease prevalence from infancy to adulthood.DesignCross-sectional household survey.SettingCommunity-based demographic surveillance site, Mirzapur, Bangladesh.Participants7275 individuals in randomly selected clusters within 156 villages.Primary and secondary outcome measuresThe 12-month prevalence of atopic dermatitis (by UK Working Party Criteria (UK criteria) and International Study of Asthma and Allergies in Childhood (ISAAC)), asthma and rhinitis (by ISAAC); disease severity (by ISAAC); history of ever receiving a medical diagnosis.ResultsChildren aged 2 years had the highest prevalence of atopic dermatitis—18.8% (95% CI 15.2% to 22.4%) by UK criteria and 14.9% (95% CI 11.6% to 18.1%) by ISAAC— and asthma (20.1%, 95% CI 16.4% to 23.8%). Prevalence of rhinitis was highest among 25–29 year olds (6.0%, (95% CI% 4.5 to 7.4%). History of a medical diagnosis was lowest for atopic dermatitis (4.0%) and highest for rhinitis (27.3%) and was significantly associated with severe disease compared with those without severe disease for all three conditions (atopic dermatitis: 30.0% vs 11.7%, p=0.015; asthma; 85.0% vs 60.4%, p<0.001; rhinitis: 34.2% vs 7.3%, p<0.001) and having a higher asset-based wealth score for asthma (29.7% (highest quintile) vs 7.5% (lowest quintile), p<0.001) and rhinitis (39.8% vs 12.5%, p=0.003). Prevalence of having >1 condition was highest (36.2%) at 2 years and decreased with age. Having atopic dermatitis (ISAAC) was associated with significantly increased odds ratios (OR) for comorbid asthma (OR 5.56 (95% CI 4.26 to 7.26)] and rhinitis (3.68 (95% CI 2.73 to 4.96)). Asthma and rhinitis were also strongly associated with each other (OR 8.39 (95% CI 6.48 to 10.86)).ConclusionsAtopic disease burden was high in this rural Bangladeshi population. Having one atopic condition was significantly associated with the presence of another. Low incidence of ever obtaining a medical diagnosis highlights an important opportunity to increase availability of affordable diagnosis and treatment options for all age groups.

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“…1 Previous studies have suggested that the prevalence of childhood asthma and wheezing in Bangladesh has been increasing over the years. 2 Although the cause of childhood asthma and wheezing is not fully understood, a recent evidence has suggested that developmental adaptations in fetal life and infancy due to early-life adverse events might result in impaired lung growth, altered immunological responses and related inflammation, and subsequently an increased risk of chronic obstructive lung diseases. 3 Early exposures include impaired fetal and infant growth patterns, preterm birth, maternal obesity, diet and smoking, child's diet, exposure to allergen, respiratory tract infections and genetic susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Effects of intrauterine growth restriction and postnatal nutrition on pediatric asthma in Bangladesh

Nozawa

Hawlader

Ferdous

et al. 2019

J Dev Orig Health Dis

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Numerous studies have investigated the risk of developing asthma due to early-life experiences and environmental exposures. However, the influence of intrauterine growth restriction and postnatal undernutrition on childhood wheezing/asthma remains unclear. Thus, we examined the effects of both small for gestational age (SGA) and postnatal stunted growth on ever asthma among children in the rural areas in Bangladesh.Multiple follow-up studies were conducted in a cohort of randomized clinical trial of nutrition interventions during pregnancy (the MINIMat trial). Overall, 1208 and 1697 children were followed-up for asthma at 4.5 and 10 years, respectively. Anthropometric measurements were obtained at various intervals from birth to 10 years of age. Ever asthma was identified using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire.Results showed that SGA was significantly associated with increased risk of ever asthma at 4.5 and 10 years after adjusting for sex, body mass index, socioeconomic status, family history of asthma, gestational age at birth, mother’s parity, mother’s age at birth and intervention trial arm [odds ratio (OR)=1.97 (95% confidence interval (CI): 1.34–2.90) and 1.86 (95% CI: 1.18–2.72)]. For the postnatal effect of undernutrition, stunting at 1 and 2 years was significantly associated with ever asthma at 4.5 and 10 years [1 year: OR=1.77 (95% CI: 1.22–2.57) and OR=1.72 (95% CI: 1.16–2.56), 2 years: OR=1.49 (95% CI: 1.06–2.10) and OR=1.41 (95% CI: 1.02–1.96)].In conclusion, SGA and undernutrition during infancy has an influence on childhood asthma among children in Bangladesh, indicating the need for nutritional interventions early in life.

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Comment on IgE responses to Ascaris and mite tropomyosins are risk factors for asthma

Cited by 4 publications

References 7 publications

Concurrent decreases in the prevalence of wheezing and Ascaris infection among 5‐year‐old children in rural Bangladesh and their regulatory T cell immunity after the implementation of a national deworming program

Concurrent decreases in the prevalence of wheezing and Ascaris infection among 5‐year‐old children in rural Bangladesh and their regulatory T cell immunity after the implementation of a national deworming program

Prevalence of atopic dermatitis, asthma and rhinitis from infancy through adulthood in rural Bangladesh: a population-based, cross-sectional survey

Effects of intrauterine growth restriction and postnatal nutrition on pediatric asthma in Bangladesh

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