Comment: Epidemiology of dementia with Lewy bodies—The Alzheimer-Parkinson overlap

Postuma, Ronald B.

doi:10.1212/wnl.0b013e3182a2cc8e

Cited by 1 publication

(1 citation statement)

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“…The discrepancy of the role of α-synuclein in AD and PD patients has been a popular research topic. The quantification of α-synuclein in CSF has been used as a biomarker to distinguish patients with AD, DLB, PD and Multiple System Atrophy (MSA) [ 37 ]. For example, in comparison with controls, CSF α-synuclein levels in AD were significantly higher, while PD, DLB and MSA subjects showed significantly lower levels of CSF α-synuclein than AD patients, but they did not significantly differ from CSF α-synuclein levels in the controls [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Mini review: linkage between α-Synuclein protein and cognition

Saleh

Yao

et al. 2015

Transl Neurodegener

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α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein function could contribute to various neurodegenerative disorders, such as Parkinson’s disease (PD), a disease with symptomatic progression of deterioration in motor and cognitive function. Recent studies show that the level of α -synuclein in cerebrospinal fluid (CSF) is highly correlated with speed of cognitive decline, suggesting a potential role of α-synuclein in cognitive function. In this mini review, we will be focus on literatures of α-synuclein in cognitive function in the non-diseased brain, as well as the impact that defective α-synuclein has on cognition in disease brain. This will be accomplished by assessing the effects of soluble α-synuclein, α-synuclein oligomers, and extracellular α-synuclein transport, on neurodegeneration.

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Section: Introductionmentioning

confidence: 99%