Combining Preoperative and Postoperative Inflammatory Indicators Can Better Predict the Recurrence of Hepatocellular Carcinoma After Partial Hepatectomy

Wu, Mingmin; Yang, Shaoxing; Feng, Xueping; Li, Chengquan; Liu, Xiangchen; Zhang, Zhenyu; Xiao, Ying; Liu, Chuchu; Dong, Jiahong

doi:10.2147/jir.s316177

Cited by 4 publications

(3 citation statements)

References 32 publications

(65 reference statements)

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“… 16 Indeed, postoperative inflammatory indicators, such as postoperative platelet–lymphocyte ratio (PostPLR) and postoperative neutrophil–lymphocyte ratio (PostNLR), can greatly affect HCC prognosis. 17–19 Various postoperative inflammatory indicators have been linked to the long-term prognosis of patients with different solid tumors. 20 , 21 For instance, PostNLR has been identified as an independent prognostic factor of survival in patients with small HCC undergoing radiofrequency ablation.…”

Section: Introductionmentioning

confidence: 99%

Combining Pre- and Postoperative Lymphocyte–C-Reactive Protein Ratios Can Better Predict Hepatocellular Carcinoma Prognosis After Partial Hepatectomy

Ni¹,

Zhan²,

Huang³

et al. 2022

JIR

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Background Various preoperative inflammatory indicators have been identified as potential predictors of poor prognosis in patients with hepatocellular carcinoma (HCC), but the role of postoperative inflammatory indicators remains unclear. This study aimed to explore the prognostic value of the postoperative lymphocyte–C-reactive protein ratio (PostLCR) on its own and combined with preoperative LCR (PreLCR). Methods A total of 290 patients with primary HCC were retrospectively enrolled in the study. Univariate analysis was used to identify factors significantly associated with poor disease-free survival (DFS) and overall survival (OS), then multivariate analysis was performed to identify independent prognostic indicators of poor survival. Prognostic models based on preoperative, postoperative, and both types of indicators were then constructed, and their predictive performance were evaluated using time-dependent receiver operating characteristic curves and the concordance index (C-index). Results PreLCR and PostLCR levels correlated with DFS and OS more strongly than other pre- and postoperative inflammatory indicators, respectively. Decreased PreLCR and PostLCR were independent prognostic factors for both DFS and OS, while HCC patients with decreased PreLCR and PostLCR had worse prognosis than patients with increased PreLCR and PostLCR. Patients into three groups based on their cut-off values of PreLCR and PostLCR, Kaplan–Meier survival analysis indicated that HCC patients with low PreLCR and PostLCR had the worst DFS and OS. The combined model showed better predictive performance at 1 and 3 years post-surgery than individual pre- and postoperative models, the American Joint Committee on Cancer/Tumor-Node-Metastasis (8th edition) staging system and the Barcelona Clinic Liver Cancer system. The combine model demonstrated a markedly superior C-index compared with the other models in DFS and OS. Conclusion Our study showed PreLCR and PostLCR are independent predictors of DFS and OS in HCC patients after partial hepatectomy. Models that include both PreLCR and PostLCR can predict prognosis better than well-established clinical staging systems.

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Section: Introductionmentioning

confidence: 99%

Combining Pre- and Postoperative Lymphocyte–C-Reactive Protein Ratios Can Better Predict Hepatocellular Carcinoma Prognosis After Partial Hepatectomy

Ni¹,

Zhan²,

Huang³

et al. 2022

JIR

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“…A 2018 study on postoperative NLR predicting prognosis and recurrence of HCC after resection showed that postoperative NLR ≥ 2.29 indicated poor prognosis, postoperative NLR ≥ 2.41 indicated early recurrence, and NLR ≥ 2.15 indicated late recurrence 46 . Recent studies have found that postoperative NLR can better predict DFS after hepatectomy, and the prognostic model combining preoperative and postoperative NLR improved the prediction performance, which is better than the Barcelona Clinic Liver Cancer staging 47 . Based on these studies, future studies on prognostic prediction models after hepatectomy should pay more attention to postoperative inflammatory indicators or the combination of multiple inflammatory indicator models.…”

Section: Role Of Inflammation In Recurrence Of Hcc After Curative Res...mentioning

confidence: 98%

“…46 Recent studies have found that postoperative NLR can better predict DFS after hepatectomy, and the prognostic model combining preoperative and postoperative NLR improved the prediction performance, which is better than the Barcelona Clinic Liver Cancer staging. 47 Based on these studies, future studies on prognostic prediction models after hepatectomy should pay more attention to postoperative inflammatory indicators or the combination of multiple inflammatory indicator models.…”

Section: Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratiomentioning

confidence: 99%

Impact of inflammation and the immune system on hepatocellular carcinoma recurrence after hepatectomy

She,

Shi,

Zhu

et al. 2024

Cancer Medicine

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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related death worldwide. Hepatectomy remains the first‐line treatment for patients with resectable HCC. However, the reported recurrence rate of HCC at 5 years after surgery is between 50% and 70%. Tumor‐related factors, including tumor size, number and differentiation, and underlying liver disease are well‐known risk factors for recurrence after treatment. In addition to tumor‐related factors, ever‐increasing amounts of studies are finding that the tumor microenvironment also plays an important role in the recurrence of HCC, including systemic inflammatory response and immune regulation. Based on this, some inflammatory and immune markers were used in predicting postoperative cancer recurrence. These include neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, cytotoxic T cells, and regulatory T cells, among others. In this review, we summarized the inflammatory and immune markers that affect recurrence after HCC resection in order to provide direction for adjuvant therapy after HCC resection and ultimately achieve the goal of reducing recurrence.

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New indexes derived from routine blood tests and their clinical application in hepatocellular carcinoma

Luo

Wang

Zhang

2022

Clinics and Research in Hepatology and Gastroenterology

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Combining Preoperative and Postoperative Inflammatory Indicators Can Better Predict the Recurrence of Hepatocellular Carcinoma After Partial Hepatectomy

Cited by 4 publications

References 32 publications

Combining Pre- and Postoperative Lymphocyte–C-Reactive Protein Ratios Can Better Predict Hepatocellular Carcinoma Prognosis After Partial Hepatectomy

Combining Pre- and Postoperative Lymphocyte–C-Reactive Protein Ratios Can Better Predict Hepatocellular Carcinoma Prognosis After Partial Hepatectomy

Impact of inflammation and the immune system on hepatocellular carcinoma recurrence after hepatectomy

New indexes derived from routine blood tests and their clinical application in hepatocellular carcinoma

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