Combining ESI, ASL and PET for quantitative assessment of drug-resistant focal epilepsy

Storti, Silvia Francesca; Galazzo, Ilaria Boscolo; Felice, Alessandra Del; Pizzini, Francesca; Arcaro, C.; Formaggio, Emanuela; Mai, Roberto; Manganotti, Paolo

doi:10.1016/j.neuroimage.2013.06.028

Cited by 60 publications

(62 citation statements)

References 58 publications

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“…Only isolated cases of neocortical epilepsy have been reported, including three patients with tuberous sclerosis , four patients with malformations of cortical development and two with post‐traumatic epilepsy . Overall, these studies correlated well with other tests .…”

Section: Discussionmentioning

confidence: 99%

Accuracy of arterial spin labeling magnetic resonance imaging (MRI) perfusion in detecting the epileptogenic zone in patients with drug‐resistant neocortical epilepsy: comparison with electrophysiological data, structural MRI, SISCOM and FDG‐PET

Sierra-Marcos¹,

Carreño²,

Setoaín

et al. 2015

Euro J of Neurology

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Section: Discussionmentioning

confidence: 99%

Accuracy of arterial spin labeling magnetic resonance imaging (MRI) perfusion in detecting the epileptogenic zone in patients with drug‐resistant neocortical epilepsy: comparison with electrophysiological data, structural MRI, SISCOM and FDG‐PET

Sierra-Marcos¹,

Carreño²,

Setoaín

et al. 2015

Euro J of Neurology

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“…There are few ASL comparative studies in other neurological disorders such as epilepsy. It has been shown that ASL has a value in detecting perfusion deficits for localization or lateralization of seizure focus . In patients with drug‐resistant temporal lobe epilepsy (TLE) (n = 10), it was found that the mean CBF values in the mesial temporal lobe of ASL and 15 O‐water PET were not significantly different, ASL and FDG‐PET data were correlated and they were also correlated with the electrophysiological data (n = 3) .…”

Section: Comparative Studies Between Asl and Pet/spect/dsc/dcementioning

confidence: 99%

“…In patients with drug‐resistant temporal lobe epilepsy (TLE) (n = 10), it was found that the mean CBF values in the mesial temporal lobe of ASL and 15 O‐water PET were not significantly different, ASL and FDG‐PET data were correlated and they were also correlated with the electrophysiological data (n = 3) . In another study, Storti et al found that seizure source (in the interictal phase) was associated with colocalized regional hypoperfusion and hypometabolism in four of six (67%) patients . Blauwblomme et al further examined interictal cerebral perfusion deficits in children with focal cortical dysplasia by means of pCASL and FDG‐PET and reported concordance (i.e., colocalized abnormalities) in 5 of 6 (83%) cases .…”

Section: Comparative Studies Between Asl and Pet/spect/dsc/dcementioning

confidence: 99%

How far is arterial spin labeling MRI from a clinical reality? Insights from arterial spin labeling comparative studies in Alzheimer's disease and other neurological disorders

Zhang

2015

Magnetic Resonance Imaging

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C linical imaging such as FDG-PET and SPECT has been well established in the diagnosis of Alzheimer's disease (AD) and other neurological disorders, but the diagnostic value of arterial spin labeling (ASL) MRI, a relatively new noninvasive imaging technique, has not been validated or confirmed. Comparative studies that compared ASL with FDG-PET, 15 O-water-PET, SPECT, dynamic susceptibility contrast-enhanced (DSC), or dynamic contrast-enhanced (DCE) MRI are important to reveal the concordance and discordance between ASL and these clinical imaging tests. This paper reviews such studies in healthy subjects and patients with AD or other neurological disorders. These comparative studies have demonstrated that ASL and FDG-PET/ 15O-water-PET had overall concordance and regional variability in healthy subjects, and the regional hypoperfusion that ASL depicted in diseases such as AD was largely concordant with the abnormalities identified by FDG-PET/ SPECT (the diagnostic performance was comparable), which suggests that ASL may have a similar diagnostic value as FDG-PET/SPECT. In addition, there are mixed findings in ASL cerebral blood flow (CBF) measurements compared with 15 O-water-PET, and ASL may be less sensitive than DSC (or DCE) in the diagnosis of neurological disorders such as stroke. Studies with large samples are needed to further validate the diagnostic value of ASL and its CBF measurement. Furthermore, it is necessary to optimize and standardize ASL parameters and explore new techniques to overcome the limitations of ASL and make it a clinical imaging alternative to invasive FDG-PET/SPECT/DSC/ DCE in the diagnosis of AD and other neurological disorders.IT IS OFTEN difficult to differentiate early-stage Alzheimer's disease (AD) from other neurodegenerative dementias or mild cognitive impairment (MCI).1 MRI, FDG-PET, and SPECT have been the major clinical imaging tests used for the diagnosis of dementia. FDG-PET or SPECT uses radioactive tracers to image glucose metabolism or brain perfusion. Since reductions in cerebral glucose uptake and brain perfusion often precede brain atrophy, measures of FDG-PET/SPECT can serve as early biomarkers for preclinical or mild AD. 2 FDG-PET/SPECT imaging in neurodegenerative disorders is based on the coupling of neural activity and glucose metabolism to reduced regional cerebral blood flow (CBF) 3 due to the synchronization of cerebral metabolic demands to regional blood supply. Thus, spatial patterns of regional CBF in perfusion imaging tend to mirror FDG-PET glucose metabolism results unless neurovascular coupling is compromised. 4In addition, CBF measurements are important in the assessment of AD and other neurological disorders such as stroke.15 O-water-PET (PET imaging with 15 O-water tracer) is considered a gold standard for quantifying CBF. 5 The diagnostic value of PET View this article online at wileyonlinelibrary.com.

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“…Multiple studies have demonstrated the utility of electrical source imaging (ESI) of high density EEG recordings for improved localization of epileptic foci in surgical candidates compared to visual interpretation of the conventional scalp EEG (Lantz et al, 2003; Holmes et al, 2008, 2010; Yamazaki et al, 2013; Storti et al, 2013; Mégevand et al, 2014; Michel et al., 2004a,b; Brodbeck et al, 2010; Zumsteg et al, 2005; Lantz et al, 2001; Brodbeck et al, 2009). A large prospective study in 151 pediatric and adult epilepsy surgery patients found that ESI using 126–256 channels and individual brain MRIs as the head model yielded a sensitivity of 84% and a specificity of 88% in identifying the seizure onset zone, which was significantly better than that obtained using low-density EEG recordings, structural MRI, PET exam, or ictal SPECT exams (Brodbeck et al, 2011).…”

mentioning

confidence: 99%

High density EEG—What do we have to lose?

Chu

2015

Clinical Neurophysiology

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Combining ESI, ASL and PET for quantitative assessment of drug-resistant focal epilepsy

Cited by 60 publications

References 58 publications

Accuracy of arterial spin labeling magnetic resonance imaging (MRI) perfusion in detecting the epileptogenic zone in patients with drug‐resistant neocortical epilepsy: comparison with electrophysiological data, structural MRI, SISCOM and FDG‐PET

Accuracy of arterial spin labeling magnetic resonance imaging (MRI) perfusion in detecting the epileptogenic zone in patients with drug‐resistant neocortical epilepsy: comparison with electrophysiological data, structural MRI, SISCOM and FDG‐PET

How far is arterial spin labeling MRI from a clinical reality? Insights from arterial spin labeling comparative studies in Alzheimer's disease and other neurological disorders

High density EEG—What do we have to lose?

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