2019
DOI: 10.1155/2019/9429761
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Abstract: In the era of personalized medicine, the management of oncological patients requires a translational and multidisciplinary approach. During early phases of cancer development, biochemical alterations of cell metabolism occur much before the formation of detectable tumour masses. Current molecular imaging techniques, targeted to the study of molecular kinetics, employ molecular tracers capable of detecting cancer lesions with both high sensitivity and specificity while also providing essential information for b… Show more

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Cited by 21 publications
(11 citation statements)
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“…Recent studies emphasized the needed for innovative multidisciplinary approaches to address the new challenges of cancer medicine [15,16,17]. In particular, great relevance has been given to the collaboration between imaging diagnostics and anatomic pathology departments [17,18,19,20,21]. The comparison and sharing of data derived by imaging procedures and histopathological analysis can shed new light on cancer mechanisms, thus providing useful information for the development and/or revaluation of diagnostic analyses.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies emphasized the needed for innovative multidisciplinary approaches to address the new challenges of cancer medicine [15,16,17]. In particular, great relevance has been given to the collaboration between imaging diagnostics and anatomic pathology departments [17,18,19,20,21]. The comparison and sharing of data derived by imaging procedures and histopathological analysis can shed new light on cancer mechanisms, thus providing useful information for the development and/or revaluation of diagnostic analyses.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, depending on the site of origin and on the histologic type of a tumoral lesion genetic alterations such as mutations, translocations and gene expression signatures are currently being assayed in clinical practice [reviewed in (11)]. As pointed out by Schillaci et al the primary goal of radiological and pathological evaluation is to increase the quality of life of oncological patients, both through the reduction and the invasiveness of the methods as well as by the accuracy of molecular analyses (12). Feasibility, robustness and reproducibility of molecular assays are therefore key in this respect and these features are strictly dependent on the integrity of DNA/RNA, which derives from a proper management of tissue during the preanalytical phase, including formalin fixation.…”
Section: Discussionmentioning
confidence: 99%
“…Because cell types cannot be determined using PET, PD-L1 IHC and PD-L1 PET will likely become better aligned in IHC assays that assess PD-L1 expression on tumor and immune cells using the combined positive score algorithm ( 75 , 76 ). With this in mind, we are optimistic that use of these techniques side by side will guide clinical decision-making in the future ( 76 ).…”
Section: The Rationale For Molecular Imaging Of Pd-(l)1: Enhancing and Complementing Current Ihc Assessment Of Pd-l1 Expressionmentioning
confidence: 99%