Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.11.023 View full text
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Katrijn De Klerck, Debby Mangelings, David Clicq, Filip De Boever, Yvan Vander Heyden

Abstract: In chiral supercritical fluid chromatography (SFC), mobile-phase additives are often used to improve enantioseparations and peak shapes. An acidic or basic additive is chosen, depending on the nature of the compound. This work highlights the simultaneous use of the acidic additive trifluoroacetic acid (TFA) and the basic additive isopropylamine (IPA) in supercritical fluid chromatography for enantioseparations. To evaluate the combination of TFA and IPA, 59 chiral pharmaceutical compounds were analyzed on four…

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