Combined therapy for Sezary syndrome with extracorporeal photochemotherapy and low-dose interferon alfa therapy. Clinical, molecular, and immunologic observations

Chymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice

“…Clinical studies have shown that mast cells are involved in the pathogenesis of various types of hair loss and alopecia. In scarring alopecia 12, 13 and androgenetic alopecia 14, the number of skin mast cells is remarkably increased. An increase in mast cells is potentially one of the reasons for remarkably higher chymase activity in skin than other organs, which may lead to alopecia in Tg mice.…”

Blood Glucose Level and Survival in Streptozotocin-Treated Human Chymase Transgenic Mice

“…Clinical studies have shown that mast cells are involved in the pathogenesis of various types of hair loss and alopecia. In scarring alopecias (19,20) and androgenetic alopecia (9), the number of skin mast cells is remarkably increased. However, determination of the infiltration of mast cells in the skin of human chymase-Tg mice was beyond the scope of this study and was not carried out.…”

Human Chymase Expression in a Mice Induces Mild Hypertension with Left Ventricular Hypertrophy

“…There are also clinical indications that mast cells are involved in the pathogenesis of several forms of hair loss and alopecia in humans. In some forms of scarring alopecias (41,42) and in androgenetic alopecia (43), the number of skin mast cells is remarkably increased. These data support the notion that mast cells function as a hair cycle regulator and are involved in the control of hair follicle regression.…”