Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle

McEwan, Conor; Kamila, Sukanta; Owen, Joshua; Nesbitt, Heather; Callan, Bridgeen; Borden, Mark A.; Nomikou, Nikolitsa; Hamoudi, Rifat; Mb, Taylor; Stride, Eleanor; McHale, Anthony P.; Callan, John F.

doi:10.1016/j.biomaterials.2015.11.033

Cited by 125 publications

(107 citation statements)

References 30 publications

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“…McEwan et al 86 demonstrated the possibility of injecting ultrasound-responsive microbubbles bearing an RB sensitizer to induce a statistically significant reduction in pancreatic tumor growth. In subsequent studies, 87,88 modification of the microbubble technique has been implemented to enhance the efficacy of delivering oxygen to the tumor microenvironment, thus increasing the amount of ROS generated.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

Vanerio

Stijnen

Mol³

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

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Section: Cancer Treatmentmentioning

confidence: 99%

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

Vanerio

Stijnen

Mol³

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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“…Conventional sonosensitizers are the same light-sensitive agents developed for photodynamic therapy [184], like hematoporphyrin and its derivatives. When loaded onto MBs [175], their circulation into the tumor vasculature can then be monitored by diagnostic UlS, so that the sonodynamic process can be initiated once detected within the mass, thus creating a therapeutic-diagnostic platform to monitor the treatment effectiveness [185][186][187]. In addition, damaging of the tumor vascularity can also be achieved through MBs (i.e., antivascular therapy).…”

Section: Microbubbles In Tumor Treatmentmentioning

confidence: 99%

Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy

et al. 2020

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Nanomaterials have great potential for the prevention and treatment of cancer. Circulating tumor cells (CTCs) are cancer cells of solid tumor origin entering the peripheral blood after detachment from a primary tumor. The occurrence and circulation of CTCs are accepted as a prerequisite for the formation of metastases, which is the major cause of cancer-associated deaths. Due to their clinical significance CTCs are intensively discussed to be used as liquid biopsy for early diagnosis and prognosis of cancer. However, there are substantial challenges for the clinical use of CTCs based on their extreme rarity and heterogeneous biology. Therefore, methods for effective isolation and detection of CTCs are urgently needed. With the rapid development of nanotechnology and its wide applications in the biomedical field, researchers have designed various nano-sized systems with the capability of CTCs detection, isolation, and CTCs-targeted cancer therapy. In the present review, we summarize the underlying mechanisms of CTC-associated tumor metastasis, and give detailed information about the unique properties of CTCs that can be harnessed for their effective analytical detection and enrichment. Furthermore, we want to give an overview of representative nano-systems for CTC isolation, and highlight recent achievements in microfluidics and lab-on-a-chip technologies. We also emphasize the recent advances in nano-based CTCs-targeted cancer therapy. We conclude by critically discussing recent CTC-based nano-systems with high therapeutic and diagnostic potential as well as their biocompatibility as a practical example of applied nanotechnology.

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“…The team went on to show that this effect could be enhanced by attaching the existing pancreatic-cancer therapies fluorouracil and gemcitabine to the microbubbles 8,9 . The group shrank tumours further by adding magnetic nanoparticles to the bubbles to push them closer to their targets using magnets outside the body 10 .…”

Section: Mechanical Engineer At the Institute Of Biomedical Engineerimentioning

confidence: 99%

Offbeat approaches to cancer research

Fleming¹

2019

Nature

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C ancer was responsible for an estimated 9.6 million deaths in 2018. Finding new ways to combat it is an important endeavour. Scientists are making advances through a variety of research methods; here, five individuals share how they've built careers in cancer research while taking innovative approaches to this problem. VERA GORBUNOVA Stay open-minded Comparative biologist at the University of Rochester in New York. Offbeat approaches to cancer research Creative thinking can pay dividends for researchers taking on cancer.

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Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle

Cited by 125 publications

References 30 publications

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy

Offbeat approaches to cancer research

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