Combined screening with mammography and ultrasound in a population-based screening program

Buchberger, W.; Geiger-Gritsch, S.; Knapp, Rudolf; Gautsch, Kurt; Oberaigner, Willi

doi:10.1016/j.ejrad.2018.01.022

Cited by 47 publications

(34 citation statements)

References 24 publications

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“…Personalized screening is debated, and several studies have been initiated investigating the potential supplemental screening using adjunct modalities (82,177). In Austria women with dense breasts are offered supplemental ultrasound (178).…”

Section: Context and Summary Of Main Findingsmentioning

confidence: 99%

Average glandular dose in paired digital mammography and digital breast tomosynthesis acquisitions in a population based screening program: effects of measuring breast density, air kerma and beam quality

et al. 2018

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The main purpose was to compare average glandular dose (AGD) for same-compression digital mammography (DM) and digital breast tomosynthesis (DBT) acquisitions in a population based screening program, with and without breast density stratification, as determined by automatically calculated breast density (Quantra). Secondary, to compare AGD estimates based on measured breast density, air kerma and half value layer (HVL) to DICOM metadata based estimates. AGD was estimated for 3819 women participating in the screening trial. All received craniocaudal and mediolateral oblique views of each breasts with paired DM and DBT acquisitions. Exposure parameters were extracted from DICOM metadata. Air kerma and HVL were measured for all beam qualities used to acquire the mammograms. Volumetric breast density was estimated using Quantra. AGD was estimated using the Dance model. AGD reported directly from the DICOM metadata was also assessed. Mean AGD was 1.74 and 2.10 mGy for DM and DBT, respectively. Mean DBT/DM AGD ratio was 1.24. For fatty breasts: mean AGD was 1.74 and 2.27 mGy for DM and DBT, respectively. For dense breasts: mean AGD was 1.73 and 1.79 mGy, for DM and DBT, respectively. For breasts of similar thickness, dense breasts had higher AGD for DM and similar AGD for DBT. The DBT/DM dose ratio was substantially lower for dense compared to fatty breasts (1.08 versus 1.33). The average c-factor was 1.16. Using previously published polynomials to estimate glandularity from thickness underestimated the c-factor by 5.9% on average. Mean AGD error between estimates based on measurements (air kerma and HVL) versus DICOM header data was 3.8%, but for one mammography unit as high as 7.9%. Mean error of using the AGD value reported in the DICOM header was 10.7 and 13.3%, respectively. Thus, measurement of breast density, radiation dose and beam quality can substantially affect AGD estimates.

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Section: Context and Summary Of Main Findingsmentioning

confidence: 99%

Average glandular dose in paired digital mammography and digital breast tomosynthesis acquisitions in a population based screening program: effects of measuring breast density, air kerma and beam quality

et al. 2018

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“…However, the sensitivity of mammography is variable and ranges from as high as 80% to 98% in women with fatty breast tissue to as low as 30% to 48% in women with dense breast tissue. 3 , 4 Because of the limitations of mammography and increase in breast cancer awareness, a few study groups have investigated the performance characteristics of supplementary screening tools, including breast ultrasonography, tomosynthesis, and magnetic resonance imaging. 5 , 6 , 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography

et al. 2021

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Key Points Question Does the performance of adjunctive ultrasonography for breast cancer detection among women undergoing screening mammography change according to breast tissue density? Findings In this secondary analysis of a randomized clinical trial, screening mammography alone demonstrated low sensitivity, whereas adjunctive ultrasonography improved sensitivity both in dense and nondense breasts. Meaning These findings suggest that adjunctive ultrasonography has the potential to improve the detection of early-stage and invasive cancers across both dense and nondense breasts and to mitigate the flaws of mammographic screening.

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“…According to Buchberger et al, combined screening with mammography and ultrasound increases the detection sensitivity to 81.3% compared to 61.5% with mammography alone in women with dense breasts [23]. Moreover, magnetic resonance imaging (MRI) has a higher sensitivity than mammography for breast cancer detection [24][25][26].…”

Section: Breast Cancer Detection 121 Breast Screeningmentioning

confidence: 99%

Characterization of a Single Pixel Beta Detector for Guidance in Breast-Conserving Surgery

Singh¹

2023

Preprint

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Breast-conserving surgery (BCS) is a challenging surgical procedure due to the lack of intraoperative image guidance available to surgeons. One potential method of intra-operative guidance would be radio-guided surgery with adiopharmaceutical emitting beta particles. In this thesis, a single pixel beta sensitive detector was constructed and characterized for intra-operative guidance during BCS. The thickness of the scintillation element of the detector was optimized to obtain a superior beta to gamma detection ratio. A computer model of the detector response was derived from an empirically measured, two-dimensional (2D) detector response. An in silico study evaluated whether the novel single pixel beta detector could detect less than 1 mm² deposits of cancer at the cut edge of the surgically excised cancerous tissue, with a sensitivity and specificity of 95%. A thickness of 0.5 mm for a CaF₂(Eu) scintillator was found to be optimal for a beta to gamma detection ratio. Additionally, according to an in silico study it is expected that with an acquisition time of 30 seconds, a tumour-to-background ratio of 5 or higher, and a normal breast tissue activity of 1.69 kBq/ml, detection of cancerous deposits of less than 1 mm² is possible. The result of this thesis demonstrate that radio-guided BCS, with a CaF₂(Eu) scintillation beta particle detector, can intra-operatively assess the tumour margin involvement, which would help surgeons in determining resection margins.

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Combined screening with mammography and ultrasound in a population-based screening program

Cited by 47 publications

References 24 publications

Average glandular dose in paired digital mammography and digital breast tomosynthesis acquisitions in a population based screening program: effects of measuring breast density, air kerma and beam quality

Average glandular dose in paired digital mammography and digital breast tomosynthesis acquisitions in a population based screening program: effects of measuring breast density, air kerma and beam quality

Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography

Characterization of a Single Pixel Beta Detector for Guidance in Breast-Conserving Surgery

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