Combined radiotherapy and surgery: local control and complications in early carcinoma of the uterine cervix — the Villejuif experience, 1975–1984

Gerbaulet, A.; Kunkler, Ian; Kerr, G.R.; Haie, C.; Michel, G; Prade, M; Lhommé, C.; M, Masselot; Albano, M.; Dutreix, A.; Chassagne, D.

doi:10.1016/0167-8140(92)90337-t

Cited by 83 publications

(27 citation statements)

References 22 publications

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“…In this series, we found complications in 44.9% of patients analysed: this value is at the upper limit of the range reported in literature (22-50%) [1][2][3][4][5][6][12][13][14][15], but we reported all complications, even if mild or showing for a short time.…”

Section: Discussionsupporting

confidence: 39%

“…Nowadays, this is the only international system based upon an accurate description of symptoms and signs of complications following multidisciplinary treatments [4]. In recent years, several authors have confirmed the reproducibility of the glossary [1][2][3][4][5][6][12][13][14][15].…”

Section: Introductionmentioning

confidence: 97%

“…Nevertheless, analysis of treatment results in cancer patients should be directed not only to survival rate, but also to the cost of complications and quality of life [1]. Additional factors influencing the choice between different treatment modalities at equal survival, include the age and general condition of the patient, the need to preserve a functional vagina and the complication rate for each treatment [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The role of the French–Italian glossary of complications in the outcome evaluation of cervical cancer treatment: an Italian multicentric study

Zola

Magistris

Landoni

et al. 2003

Critical Reviews in Oncology/Hematology

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Section: Discussionsupporting

confidence: 39%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The role of the French–Italian glossary of complications in the outcome evaluation of cervical cancer treatment: an Italian multicentric study

Zola

Magistris

Landoni

et al. 2003

Critical Reviews in Oncology/Hematology

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“…This has been also the experience of the Villejuif Institute [11], where patients did better when treated with radiation therapy combined with concurrent chemotherapy, followed by hysterectomy.…”

Section: Discussionmentioning

confidence: 91%

LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

Amendola¹,

Pérez²,

Amendola³

et al. 2010

Cureus

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“…Most cases of early-stage invasive cervical carcinoma can be cured by a combination of surgery, radiotherapy and chemotherapy (Gerbaulet et al, 1992;Morris et al, 1999). However, some tumours relapse at short term and are lethal in most of the cases, despite chemotherapy (Omura et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma

et al. 2005

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Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved in the progression of invasive cervical carcinoma, we performed a gene expression study on cases selected according to viral and clinical parameters. Using Coupled Two-Way Clustering and Sorting Points Into Neighbourhoods methods, we identified a 'cervical cancer proliferation cluster' composed of 163 highly correlated transcripts. Most of these transcripts corresponded to E2F pathway genes controlling cell division or proliferation, whereas none was known as TP53 primary target. The average expression level of the genes of this cluster was higher in tumours with an early relapse than in tumours with a favourable course (P ¼ 0.026). Moreover, we found that E6/E7 mRNA expression level was positively correlated with the expression level of the cluster genes and with viral DNA load. These findings suggest that HPV E6/E7 expression level plays a key role in the progression of invasive carcinoma of the uterine cervix via the deregulation of cellular genes controlling tumour cell proliferation. HPV expression level may thus provide a biological marker useful for prognosis assessment and specific therapy of the disease.

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Combined radiotherapy and surgery: local control and complications in early carcinoma of the uterine cervix — the Villejuif experience, 1975–1984

Cited by 83 publications

References 22 publications

The role of the French–Italian glossary of complications in the outcome evaluation of cervical cancer treatment: an Italian multicentric study

The role of the French–Italian glossary of complications in the outcome evaluation of cervical cancer treatment: an Italian multicentric study

LATTICE Radiotherapy with RapidArc for Treatment of Gynecological Tumors:Dosimetric and Early Clinical Evaluations

Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma

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