Combined oral contraceptive pills for treatment of acne

Abstract

The four COCs evaluated in placebo-controlled trials are effective in reducing inflammatory and non-inflammatory facial acne lesions. Few important differences were found between COC types in their effectiveness for treating acne. How COCs compare to alternative acne treatments is unknown since limited data were available regarding this question.

The efficacy of oral isotretinoin versus cyproterone compound in female patients with acne and the triad of cutaneous hyperandrogenism: A randomized clinical trial

“…[ 12 ] However, women with identifiable endocrinologic conditions and those with severe acne are the best candidates for hormonal therapy. [ 21 22 23 24 ] In addition to inhibiting the secretion of follicle-stimulating hormone and luteinizing hormone, another interesting mechanism by which cyproteronacetate is therapeutic is interfering with the binding of dihydrotestosterone to the androgen receptor due to the possibility of menstrual changes. [ 8 ] Despite the earlier reduction in the value of the ASI at the end of first month in the subjects of group A ( P value = 0.03), by statistical analysis no significance difference was found between two groups at the end ( P value = 0.62).…”

The efficacy of oral isotretinoin versus cyproterone compound in female patients with acne and the triad of cutaneous hyperandrogenism: A randomized clinical trial

“…[ 12 ] However, women with identifiable endocrinologic conditions and those with severe acne are the best candidates for hormonal therapy. [ 21 22 23 24 ] In addition to inhibiting the secretion of follicle-stimulating hormone and luteinizing hormone, another interesting mechanism by which cyproteronacetate is therapeutic is interfering with the binding of dihydrotestosterone to the androgen receptor due to the possibility of menstrual changes. [ 8 ] Despite the earlier reduction in the value of the ASI at the end of first month in the subjects of group A ( P value = 0.03), by statistical analysis no significance difference was found between two groups at the end ( P value = 0.62).…”

Contraception technology: past, present and future

“…and HMB [77] with a decrease in lost days of work [78]. Also, some combined OCs are also being used in the treatment of acne and premenstrual dysphoric disorder [79–80]. …”

Adult Female Acne: Recent Advances in Pathophysiology and Therapeutic Approaches

“…Inhibitors of ovarian androgen production are oral contraceptive pills containing a combination of estradiol and a progestin with antiandrogen activity, such as CPA or drospirenone. These combinations seem to be more effective compared to those containing modern progestatives (levonorgestrel, desogestrel, norgestimate, gestodene) [96]. The medications are effective in both inflammatory and non-inflammatory acne, but the effects occur upon prolonged treatment, with a 62% reduction in inflammatory lesions at 6 months [97].…”

The efficacy of oral isotretinoin versus cyproterone compound in female patients with acne and the triad of cutaneous hyperandrogenism: A randomized clinical trial

“…[ 12 ] However, women with identifiable endocrinologic conditions and those with severe acne are the best candidates for hormonal therapy. [ 21 22 23 24 ] In addition to inhibiting the secretion of follicle-stimulating hormone and luteinizing hormone, another interesting mechanism by which cyproteronacetate is therapeutic is interfering with the binding of dihydrotestosterone to the androgen receptor due to the possibility of menstrual changes. [ 8 ] Despite the earlier reduction in the value of the ASI at the end of first month in the subjects of group A ( P value = 0.03), by statistical analysis no significance difference was found between two groups at the end ( P value = 0.62).…”

Contraception technology: past, present and future

“…and HMB [77] with a decrease in lost days of work [78]. Also, some combined OCs are also being used in the treatment of acne and premenstrual dysphoric disorder [79–80]. …”

Adult Female Acne: Recent Advances in Pathophysiology and Therapeutic Approaches

“…Inhibitors of ovarian androgen production are oral contraceptive pills containing a combination of estradiol and a progestin with antiandrogen activity, such as CPA or drospirenone. These combinations seem to be more effective compared to those containing modern progestatives (levonorgestrel, desogestrel, norgestimate, gestodene) [96]. The medications are effective in both inflammatory and non-inflammatory acne, but the effects occur upon prolonged treatment, with a 62% reduction in inflammatory lesions at 6 months [97].…”

The efficacy of oral isotretinoin versus cyproterone compound in female patients with acne and the triad of cutaneous hyperandrogenism: A randomized clinical trial

“…[ 12 ] However, women with identifiable endocrinologic conditions and those with severe acne are the best candidates for hormonal therapy. [ 21 22 23 24 ] In addition to inhibiting the secretion of follicle-stimulating hormone and luteinizing hormone, another interesting mechanism by which cyproteronacetate is therapeutic is interfering with the binding of dihydrotestosterone to the androgen receptor due to the possibility of menstrual changes. [ 8 ] Despite the earlier reduction in the value of the ASI at the end of first month in the subjects of group A ( P value = 0.03), by statistical analysis no significance difference was found between two groups at the end ( P value = 0.62).…”

Contraception technology: past, present and future

“…and HMB [77] with a decrease in lost days of work [78]. Also, some combined OCs are also being used in the treatment of acne and premenstrual dysphoric disorder [79–80]. …”

Adult Female Acne: Recent Advances in Pathophysiology and Therapeutic Approaches

“…Inhibitors of ovarian androgen production are oral contraceptive pills containing a combination of estradiol and a progestin with antiandrogen activity, such as CPA or drospirenone. These combinations seem to be more effective compared to those containing modern progestatives (levonorgestrel, desogestrel, norgestimate, gestodene) [96]. The medications are effective in both inflammatory and non-inflammatory acne, but the effects occur upon prolonged treatment, with a 62% reduction in inflammatory lesions at 6 months [97].…”