Combined Live Measles, Mumps, Rubella Vaccine

Mumps

“…Of 163 reported cases in the United States in 1972,44.2% of the patients were age 5--9, 16.6% age 0-4, and 16.0% age 10--14. The remainder of cases were scattered throughout all other age groups. A similar age distribution was seen in 76 cases of aseptic meningitis reported in the same period. Mumps-associated deaths in 158 cases from 1966 to 1971 were distributed by age as follows: 38% over age 40,22.2% age 5--9 yr, and 19% age 0-4 yr.…”

What’s going on with measles?

“…These candidate LAMVs produced no disease in macaques and provided protection from challenge with wild-type measles virus (70,71). The LAMV licensed in 1963 frequently produced fever and rash (72,73). Further passage in tissue culture yielded the current LAMVs that cause fever and rash in less than 10% of immunized children (74,75).…”

Investigating the Interaction between Negative Strand RNA Viruses and Their Hosts for Enhanced Vaccine Development and Production

“…MV is an antigenically invariant pathogen where acute infection elicits protective immunity in convalescent persons. This allowed the licensing of a live virus attenuated vaccine via passage of a human isolate through tissue culture [97]. Vaccination provides life-long immunity after two inoculations during childhood.…”