Combined linkage and linkage disequilibrium mapping for genome screens

Genome-wide analysis of acute low salinity tolerance in the eastern oyster Crassostrea virginica and potential of genomic selection for trait improvement

“…In contrast, the family-specific QTL analyses did not detect these additional QTL, but there does seem to be a suggestive QTL on chromosome 8 for family 22 ( Figure 2 ). Previous studies have also observed increases in detection ability for combined LD mapping ( Xiong and Jin 2000 ; Lu et al 2010 ). In our scenario, the combined LD analysis provided the most powerful analysis but is complemented by the independent QTL mapping results.…”

Genome-wide analysis of acute low salinity tolerance in the eastern oyster Crassostrea virginica and potential of genomic selection for trait improvement

“…In contrast, the family-specific QTL analyses did not detect these additional QTL, but there does seem to be a suggestive QTL on chromosome 8 for family 22 ( Figure 2 ). Previous studies have also observed increases in detection ability for combined LD mapping ( Xiong and Jin 2000 ; Lu et al 2010 ). In our scenario, the combined LD analysis provided the most powerful analysis but is complemented by the independent QTL mapping results.…”

Improvement of Mapping Accuracy by Unifying Linkage and Association Analysis

“…Heuristically, exploiting information on allele sharing contained in each sibship can achieve this aim and also circumvent the weakness that association is required for linkage to be detected. Such attempts have been pursued by a number of researchers (e.g., Zhao et al 1998;Xiong and Jin 2000;Cantor et al 2005;Li et al 2005). In our previous study (Lou et al 2005), we reported the development of a statistical framework with two hierarchies.…”

Association Testing in a Linked Region Using Large Pedigrees

“…The present report announces the implementation of a maximum-likelihood method for joint analysis, as advocated by Xiong and Jin (2000), on the basis of earlier hints in the literature (MacLean et al 1984;Tienari et al 1992;Zhao et al 1998). To our knowledge, no one, including Xiong and Jin, has implemented it for general pedigrees.…”

Genome-wide analysis of acute low salinity tolerance in the eastern oyster Crassostrea virginica and potential of genomic selection for trait improvement

“…In contrast, the family-specific QTL analyses did not detect these additional QTL, but there does seem to be a suggestive QTL on chromosome 8 for family 22 ( Figure 2 ). Previous studies have also observed increases in detection ability for combined LD mapping ( Xiong and Jin 2000 ; Lu et al 2010 ). In our scenario, the combined LD analysis provided the most powerful analysis but is complemented by the independent QTL mapping results.…”

Improvement of Mapping Accuracy by Unifying Linkage and Association Analysis

“…Heuristically, exploiting information on allele sharing contained in each sibship can achieve this aim and also circumvent the weakness that association is required for linkage to be detected. Such attempts have been pursued by a number of researchers (e.g., Zhao et al 1998;Xiong and Jin 2000;Cantor et al 2005;Li et al 2005). In our previous study (Lou et al 2005), we reported the development of a statistical framework with two hierarchies.…”

Association Testing in a Linked Region Using Large Pedigrees

“…The present report announces the implementation of a maximum-likelihood method for joint analysis, as advocated by Xiong and Jin (2000), on the basis of earlier hints in the literature (MacLean et al 1984;Tienari et al 1992;Zhao et al 1998). To our knowledge, no one, including Xiong and Jin, has implemented it for general pedigrees.…”

Genome-wide analysis of acute low salinity tolerance in the eastern oyster Crassostrea virginica and potential of genomic selection for trait improvement

“…In contrast, the family-specific QTL analyses did not detect these additional QTL, but there does seem to be a suggestive QTL on chromosome 8 for family 22 ( Figure 2 ). Previous studies have also observed increases in detection ability for combined LD mapping ( Xiong and Jin 2000 ; Lu et al 2010 ). In our scenario, the combined LD analysis provided the most powerful analysis but is complemented by the independent QTL mapping results.…”

Improvement of Mapping Accuracy by Unifying Linkage and Association Analysis

“…Heuristically, exploiting information on allele sharing contained in each sibship can achieve this aim and also circumvent the weakness that association is required for linkage to be detected. Such attempts have been pursued by a number of researchers (e.g., Zhao et al 1998;Xiong and Jin 2000;Cantor et al 2005;Li et al 2005). In our previous study (Lou et al 2005), we reported the development of a statistical framework with two hierarchies.…”

Association Testing in a Linked Region Using Large Pedigrees

“…The present report announces the implementation of a maximum-likelihood method for joint analysis, as advocated by Xiong and Jin (2000), on the basis of earlier hints in the literature (MacLean et al 1984;Tienari et al 1992;Zhao et al 1998). To our knowledge, no one, including Xiong and Jin, has implemented it for general pedigrees.…”