Combined iodine-125 plaque irradiation and indirect ophthalmoscope laser therapy of choroidal malignant melanomas: Comparison with iodine-125 and cobalt-60 plaque radiotherapy alone

Abstract

The authors studied the short-term impact of combined episcleral iodine-125 plaque radiotherapy and argon laser treatment in a series of 24 patients with choroidal malignant melanoma. All patients underwent plaque therapy prior to their initial laser session. All laser treatments were performed with an indirect ophthalmoscope argon green laser, using low-power, long-duration exposures. The endpoint of laser therapy was a well-defined atrophic circumbasal chorioretinal laser scar and complete or nearly complete nonfluorescence of the lesion on fluorescein angiography. In a case-by-case matched comparison study, the authors evaluated the relative local regression of tumors treated by combined plaque-laser therapy, iodine-125 plaque therapy alone, and cobalt-60 plaque therapy alone. The tumors treated with supplemental laser regressed substantially faster and more completely than did those treated by either type of plaque therapy alone. However, the short-term visual loss was greater in eyes treated by the combined therapy.

Effect of an anti‐CD54 (ICAM‐1) monoclonal antibody (UV3) on the growth of human uveal melanoma cells transplanted heterotopically and orthotopically in SCID mice

“…Indeed, liver metastases are present in up to 95% of the patients who die from uveal melanomas. [7][8][9][10] Although there have been advances in the treatment of primary uveal melanomas, the 5-year survival rate for uveal melanoma patients has not improved in the past 30 years. 1,10 Moreover, no therapeutic modality prevents the metastasis of uveal melanoma or prolongs the survival of patients.…”

Immune escape mechanisms of intraocular tumors

“…Although cutaneous and uveal melanomas arise from neural crest progenitors, they differ significantly in their epidemiological (Mahoney et al , 1990), cytogenetic (McCarthy et al , 1993), metastatic (Augsburger et al , 1993; Char, 1978; Niederkorn, 1995; Vijayasaradhi and Houghton, 1995), and immunological (Niederkorn, 1995) characteristics. Uveal melanomas and cutaneous melanomas display remarkably different metastatic behavior.…”

“…While cutaneous melanomas can metastasize to a wide variety of organs, uveal melanomas display a propensity to metastasize to the liver. In fact, liver metastases are present in up to 95% of the patients who die with uveal melanoma (Albert, 1997; Augsburger et al , 1993; COMS, 2001; Kath et al , 1993). An interesting dichotomy between cutaneous melanoma and uveal melanoma is found in the correlation between MHC class I expression and malignancy.…”

Transpupillary thermotherapy in treatment of melanoma of choroid of T1 stage

“…Ýôôåêòèâíîñòü îðãàíîñîõðàíÿþùåãî ëå÷åíèÿ ÓÌ, ïî äàííûì ëèòåðàòóðû, âûøå, ÷åì ïðè ïðîâåäåíèè ýíóêëåàöèè. Ìíîãèå èññëåäîâàòåëè îòìå÷àþò óâåëè÷åíèå ïðîäîëaeèòåëüíîñòè aeèçíè áîëüíîãî ñ ÓÌ ïîñëå îðãàíîñîõðàíÿþùåãî ëå÷åíèÿ: 5 ëåò ïîñëå ëå÷åíèÿ aeèâóò 80-93 % áîëüíûõ [4, 47,53], áîëåå 10 ëåò -72-79 % áîëüíûõ [52,54,95], áîëåå 15 ëåò -72 % [52,135,136]. Ýòî îáñòîÿòåëüñòâî ñïî-ñîáñòâóåò äàëüíåéøèì ïîèñêàì â ðàçðàáîòêå íîâûõ ìåòîäîâ îðãàíîñîõðàíÿþùåãî ëå÷åíèÿ è êîìáèíàöèè óaeå ñóùåñòâóþùèõ.…”