Combined Exercise Training Improves Glycemic Control in Adult with Cystic Fibrosis

Abstract

A combined exercise program improves glycemic control in CF.

Relationship between exercise capacity and glucose tolerance in cystic fibrosis

“…Future studies should also examine which types of exercise training and duration of training that would be optimal to achieve improvements in VO 2 and glucose tolerance as both are desirable outcomes in CF. Overall, the results of our study and Beaudoin et al suggest that improvements in glucose tolerance may be an additional benefit of exercise training. Prospective studies are needed to further evaluate this role of exercise in the management and possible prevention of CFRD similar to what has been demonstrated in gestational and type 2 diabetes …”

“…The effect of exercise training on glucose tolerance has been examined in a small study of adult patients with CFRD and abnormal glucose tolerance. Beaudoin et al demonstrated improvement in 2 h plasma glucose values in eight subjects following a 12 week combined strength and aerobic exercise program compared to six control subjects. The exercise group also demonstrated improvements in insulin sensitivity and strength measures, but there was no change in VO 2 or exercise capacity which the authors speculated may be a result of a shorter duration of exercise training.…”

“…Impaired glucose tolerance and CFRD is mainly characterized by reduced insulin secretion, but few studies are now demonstrating that insulin sensitivity may also play a role in variable glucose tolerance. 19,33 Our study was not designed to measure these mechanisms of glucose prospective study designs are warranted to further examine the relationship between glucose tolerance and EC.…”

“…In contrast, Junge et al reported that eleven adolescents with CFRD had a significantly lower EC measured by peak workload or watts on a cardiopulmonary exercise test (CPET) compared to age and gender matched CF peers who were not diagnosed with CFRD. In a more recent study evaluating exercise training instead of EC, Beaudoin et al found that eight adult CF patients with abnormal glucose tolerance or CFRD who completed a 12‐week exercise training program significantly reduced their two‐hour plasma glucose values during an oral glucose tolerance test (OGTT) (−2.34 ± 1.26 mmol/L, P < 0.007), while there were no OGTT changes in the six control patients. These studies show some evidence that a relationship exists between EC or exercise training and glucose tolerance in CF, but they utilized different methods of assessing exercise capacity, examined relatively small numbers of patients, and were limited mostly to adult patients.…”

Cystic fibrosis related diabetes: Medical management

“…It also has significant positive benefits in all forms of diabetes. In CFRD exercise has been shown to reduce postprandial glycaemic excursions and total glucose excursions [14]. Therefore, appropriate exercise should be encouraged after the diagnosis of CFRD or dysglycaemia.…”