Combined effects of the implementation of magnesium and ascorbic acid on myocardial ischemia-reperfusion in open heart surgery

Gültekin, Yıldırım; Güzel, Abdulkadir; Karakaya, Atalay; Beşoğul, Yavuz

doi:10.38053/acmj.982137

Cited by 2 publications

(2 citation statements)

References 34 publications

(33 reference statements)

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“…1 ). Four trials were excluded due to suspected data duplication [ 37 , 38 ], unclear troponin-related outcome [ 39 ] and poor data reporting in general [ 40 – 43 ]. Seven trials were included in the meta-analysis of which four trials reported the changes of TnI and five of CKMB (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis

Rozemeijer,

Hemilä,

van Baaren

et al. 2023

BMC Cardiovasc Disord

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Background Ischemia/reperfusion injury contributes to periprocedural myocardial injury (PMI) in patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). PMI can be estimated by the elevation of troponin (Tn) and creatine kinase-MB (CKMB) plasma levels, and it is associated with increased risk of cardiovascular events and mortality. Vitamin C might have a beneficial effect on PMI by improving endothelial function, improving myocardial perfusion, and by reducing oxidative stress generated during/after reperfusion. In several small animal models of cardiac stress, vitamin C reduced the increase in Tn and CKMB levels. The aim of this meta-analysis was to investigate whether vitamin C administration may have an effect on Tn and CKMB levels in patients undergoing PCI or CABG. Methods We searched PubMed, Cochrane, Embase and Scopus databases for controlled clinical trials reporting on Tn and CKMB levels in adult patients who underwent PCI or CABG and received vitamin C. As secondary outcomes we collected data on biomarkers of oxidative stress in the included trials. In our meta-analysis, we used the relative scale and estimated the effect as the ratio of means. Results We found seven controlled trials which included 872 patients. All included trials administered vitamin C intravenously, with a range from 1 to 16 g/day, and all initiated vitamin administration prior to the procedure. Vitamin C decreased peak Tn plasma levels in four trials on average by 43% (95% CI: 13 to 63%, p = 0.01) and peak CKMB plasma levels in five trials by 14% (95% CI: 8 to 21%, p < 0.001). Vitamin C also significantly decreased the biomarkers of oxidative stress. Conclusions Vitamin C may decrease cardiac enzyme levels in patients undergoing elective PCI or CABG. This may be explained partially by its antioxidant effects. Our findings encourage further research on vitamin C administration during cardiac procedures and in other clinical contexts that increase the level of cardiac enzymes. Future studies should search for an optimal dosing regimen, taking baseline and follow-up plasma vitamin C levels into account.

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Section: Resultsmentioning

confidence: 99%

Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis

Rozemeijer,

Hemilä,

van Baaren

et al. 2023

BMC Cardiovasc Disord

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“…In another study, the combined effects of magnesium (Mg) and high-dose AA on cardiac Ischemia Perfusion (IP) damage were investigated; it was determined that to reduce IP, Mg with a high dose of AA can be effective in patients undergoing heart surgery, and it is effective to improve the disease outcomes (60,92).…”

Section: Humanmentioning

confidence: 99%

The Effect of Vitamin C on Ischemia-Reperfusion Injury: A Systematic Review

Masmouei,

Zarei,

Habibi Dehkordi

et al. 2024

JIMC

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Ischemia is one of the most common injuries that is usually caused by reduced blood flow to the tissues. Following this incident, the tissue becomes deficient in oxygen and nutrients, and energy production in the affected cells stops, eventually leading to cell damage, but there is also evidence that restoring blood flow to ischemic tissues can lead to extra tissue damage known as Ischemia Reperfusion Injury (IRI). In this study, we reviewed the relationship between vitamin C intake and ischemia/reperfusion injury to investigate the relationship between vitamin C intake and ischemia/reperfusion injury. The keywords “Vitamin C” or “Ascorbic Acid” and “Ischemic” or “Ischemia” and “Reperfusion” were used in this search. The results show that vitamin C has a positive effect on ischemia treatment in the renal tissue, brain, liver, intestine, lung, ovary, pancreas, and skin.

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Combined effects of the implementation of magnesium and ascorbic acid on myocardial ischemia-reperfusion in open heart surgery

Cited by 2 publications

References 34 publications

Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis

Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis

The Effect of Vitamin C on Ischemia-Reperfusion Injury: A Systematic Review

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