Combined effects of microplastics and chemical contaminants on the organ toxicity of zebrafish ( Danio rerio )

Rainieri, Sandra; Conlledo, Nadia; Larsen, Bodil Katrine; Granby, Kit; Barranco, Alejandro

doi:10.1016/j.envres.2017.12.019

Cited by 336 publications

(108 citation statements)

References 43 publications

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“…This result shows that although MPs can as vector of contamination, contaminant transfer is limited compared to other exposure routes. The same phenomenon has been observed in most studies comparing contaminant uptake (PCBs, BFRs, PFCs, PBDEs, PAHs and organic contaminants) via MPs and other matrices [32][33][34] , although one study showed higher contaminant transfer in fish when exposed via…”

Section: Chlorpyrifos Uptake In Fish and Vector Effect Of Microplasticssupporting

confidence: 77%

“…Similarly to our results, studies assessing the ecotoxicity of PE MPs on fish exposed via trophic chains also reported no effects [37][38][39] . Moreover, most studies exposing fish via water showed either no effects 34,[40][41][42][43] or mild effects, which include inhibition of AChE activity, impaired energy reserves, decreased swimming and predatory performances, changes in plasma biochemistry and histological changes in gills [44][45][46][47][48] . The adverse effects observed with pristine PE MPs in these studies could be due to the presence of monomers or additives 5 sorbed on MPs but that were not reported, either because no chemical analysis was performed or because concentrations were below limits of detection.…”

Section: Effect Of Contaminantsmentioning

confidence: 99%

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Microplastic vector effects: are fish at risk when exposed via the trophic chain?

Bour

Sturve

Höjesjö

et al. 2019

Preprint

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In aquatic organisms, trophic transfer is an important exposure route for microplastics (MPs).Despite their relevance, effect studies on fish exposed via trophic chains are currently very scarce.MPs are known to contain many chemicals that could be transferred to organisms and induce deleterious effects. However, there is currently no consensus on whether MPs represent a significant exposure pathway to chemicals in contaminated habitats. Here, we exposed threespined stickleback (Gasterosteus aculeatus) to polyethylene MPs via prey ingestion, in a longterm experiment. MPs were either pristine or spiked with chlorpyrifos (CPF), and a CPF control was included to compare vector effects of MPs and natural prey. No effect was observed in fish exposed to pristine MPs. CPF accumulation was observed in fish exposed to CPF-spiked MPs (MP-CPF), confirming the vector potential of MPs. However, CPF accumulation was more important in fish exposed to CPF via prey. In fish exposed to MP-CPF, we observed significant AChE inhibition and hyperactivity, which could result in increased vulnerability to predation. CPF organ distribution differed between groups, suggesting that chemical exposure via MPs could alter organ distribution of chemicals. This can result in a change in the organs most at risk, likely increasing intestine exposure.

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Section: Chlorpyrifos Uptake In Fish and Vector Effect Of Microplasticssupporting

confidence: 77%

Section: Effect Of Contaminantsmentioning

confidence: 99%

Microplastic vector effects: are fish at risk when exposed via the trophic chain?

Bour

Sturve

Höjesjö

et al. 2019

Preprint

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show abstract

“…In line with MPs/NPs activity as carriers or vectors of environmental contaminants, studies using fish cell lines have revealed that, while pristine plastics show no toxicity, those sampled from different islands around the world do [96], and so do those that have been mixed with human pharmaceuticals [97]. MPs/NPs were shown to modulate the toxicities a range of pollutants/toxicants, including phenanthrene [75], mercury [49], cadmium [46][47][48], polychlorinated biphenyls (PCBs) [98], gold ions [99], and the antibiotic roxithromycin [100], in fishes. However, adsorption of toxicants by the plastics could also potentially lower their toxicity, and such is the case for a complex mixture of polycyclic aromatic hydrocarbons (PAHs) [101].…”

Section: Toxicity Of Mps/nps In Fishesmentioning

confidence: 99%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

521

280

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Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

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“…Another line of evidence suggests that the combined effect of microplastics and sorbed contaminants altered organs homeostasis in a greater manner than the contaminants alone (Rainieri et al 2018). This can only be further evaluated with controlled laboratory exposures to facilitate monitoring of the uptake, movement, and distribution of chemical compounds in whole organisms and excised tissues such as gills, intestinal tract, and liver (Lusher et al 2017).…”

Section: Leaching Additives and Persistent Organic Pollutants: The Rementioning

confidence: 99%

Understanding How Microplastics Affect Marine Biota on the Cellular Level Is Important for Assessing Ecosystem Function: A Review

Prinz

Korez

2019

YOUMARES 9 - The Oceans: Our Research, Our Future

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Plastic has become indispensable for human life. When plastic debris is discarded into waterways, these items can interact with organisms. Of particular concern are microscopic plastic particles (microplastics) which are subject to ingestion by several taxa. This review summarizes the results of cutting-edge research about the interactions between a range of aquatic species and microplastics, including effects on biota physiology and secondary ingestion. Uptake pathways via digestive or ventilatory systems are discussed, including (1) the physical penetration of microplastic particles into cellular structures, (2) leaching of chemical additives or adsorbed persistent organic pollutants (POPs), and (3) consequences of bacterial or viral microbiota contamination associated with microplastic ingestion. Following uptake, a number of individual-level effects have been observed, including reduction of feeding activities, reduced growth and reproduction through cellular modifications, and oxidative stress. Microplastic-associated effects on marine biota have become increasingly investigated with growing concerns regarding human health through trophic transfer. We argue that research on the cellular interactions with microplastics provide an understanding of their impact to the organisms' fitness and, therefore, its ability to sustain their functional role in the ecosystem. The review summarizes information from 236 scientific publications. Of those, only 4.6% extrapolate their research of microplastic intake on individual species to the impact on ecosystem functioning. We emphasize the need for risk evaluation from organismal effects to an ecosystem level to effectively evaluate the effect of microplastic pollution on marine environments. Further studies are encouraged to investigate sublethal effects in the context of environmentally relevant microplastic pollution conditions.

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Combined effects of microplastics and chemical contaminants on the organ toxicity of zebrafish ( Danio rerio )

Cited by 336 publications

References 43 publications

Microplastic vector effects: are fish at risk when exposed via the trophic chain?

Microplastic vector effects: are fish at risk when exposed via the trophic chain?

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Understanding How Microplastics Affect Marine Biota on the Cellular Level Is Important for Assessing Ecosystem Function: A Review

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