Combined Effect in vitro of Chemotherapy with Agents Acting on the Cell Membrane of Lewis Lung Carcinoma

Abstract

The treatment of cancer is often impeded by the emergence of drug-resistant clones. Drug resistance is in many cases due to a decreased drug accumulation in the tumor cell. Membrane-acting agents, by increasing cell permeability, might counteract the loss of sensitivity to drugs. In the present study, the effect of two membrane-acting agents, hyperthermia and the calcium channel blocker verapamil, on the action of adriamycin (ADR) on Lewis lung carcinoma (3LL) was examined. Hyperthermia increased drastically the antitumoral effect of ADR. The effectiveness of the combined ADR-hyperthermia treatment was proportional to the ADR dose and to the degree of hyperthermia. Verapamil had a similar effect but at higher ADR doses. Treatment modalities designed for the circumvention of drug resistance could be one approach in the attempt to find a way to control cancer.

Enhancement of Doxorubicin-Induced Cytotoxicity by Hyperthermia in Ehrlich Ascites Cells

“…This has been observed in this study ( fig. 1, 2) and oth ers [22][23][24]. In the present work, total lipid and cholesterol content ( fig.…”

Isothermal kinase-triggered supramolecular assemblies as drug sensitizers

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