2014
DOI: 10.1002/lsm.22235
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Abstract: Background and Objective Treatment modalities, such as hyperthermia and photodynamic therapy (PDT) have been used in the treatment of a variety of head and neck squamous cell carcinoma (HNSCC), either alone or as an adjuvant therapy. Macrophages loaded with gold nanoshells, which convert near-infrared light to heat, can be used as transport vectors for photothermal hyperthermia of tumors. The purpose of this study was to investigate the effects of combined macrophage mediated photothermal therapy (PTT) and PDT… Show more

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Cited by 63 publications
(48 citation statements)
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References 47 publications
(56 reference statements)
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“…The ability of Mo/Ma to phagocytose several types of nanoparticles including Au NS , Au NR and SPIO have been investigated by our group as well as by several other workers [9][10][11][37][38][39][40]. Our own results, employing both Mo and Ma from mouse and rat, respectively, are in general agreement with the results reported by others.…”
Section: Mo/ma Phagocytosis Of Bare or Polyethylene Glycol Coated (Pesupporting
confidence: 95%
See 1 more Smart Citation
“…The ability of Mo/Ma to phagocytose several types of nanoparticles including Au NS , Au NR and SPIO have been investigated by our group as well as by several other workers [9][10][11][37][38][39][40]. Our own results, employing both Mo and Ma from mouse and rat, respectively, are in general agreement with the results reported by others.…”
Section: Mo/ma Phagocytosis Of Bare or Polyethylene Glycol Coated (Pesupporting
confidence: 95%
“…Taken together, these studies indicate a synergistic effect between the two therapeutic modalities. Along these lines, we have examined the ability of Ma NS -mediated PTT to potentiate the cytotoxic effects of PDT for squamous cell head and neck carcinoma [39] as well as rat gliomas cells. Two different light wavelengths were employed simultaneously, one to activate a highly efficient PDT photosensitizer (λ = 670 nm) and the other for Ma NS -mediated PTT (λ = 810 nm).…”
Section: Combined Photothermal and Photodynamic Therapymentioning
confidence: 99%
“…PTT is an effective method of achieving rapid elevated temperatures in targeted regions in the presence of NIR absorbing gold nanoparticles while limiting damage to normal structures. The efficacy of PTT induced moderate hyperthermia in several forms of combined therapy has been shown to be effective [34][35][36]. Experiments examining the effects of combined PTT + PCI treatment modalities are in progress.…”
Section: Combined Pci Mediated Chemotherapy and External Induced Mhtmentioning
confidence: 99%
“…[15][16][17] The concept of using cells as drug delivery vehicles is rapidly developing. [18][19][20] The use of natural cellular membranes to camouflage synthetic polymeric nanoparticles has demonstrated significant potential. [21][22][23][24][25] In this study, the membranes of human cytotoxic T lymphocytes (hCTLs) were chosen to produce cancer-targeting nanoparticles, because of the long blood circulation time and the ability to recruit and localize at tumor sites, of this cell type.…”
Section: Introductionmentioning
confidence: 99%