2022
DOI: 10.1002/1873-3468.14465
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Abstract: The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will prop… Show more

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Cited by 5 publications
(4 citation statements)
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“…Humans are exposed to several endocrine-disrupting chemicals (EDCs), which may interfere with endocrine system functions through the specific pathogenic mechanisms of action [ 46 , 47 ]. Our knowledge of EDCs effects on human health has greatly improved over the last decade [ 48 , 49 , 50 ]. “Obesogen” EDCs accumulate in adipose tissue, and this can lead to interactions and changes in the endocrine activity of adipose tissue and homeostatic systems underlying weight control.…”
Section: Resultsmentioning
confidence: 99%
“…Humans are exposed to several endocrine-disrupting chemicals (EDCs), which may interfere with endocrine system functions through the specific pathogenic mechanisms of action [ 46 , 47 ]. Our knowledge of EDCs effects on human health has greatly improved over the last decade [ 48 , 49 , 50 ]. “Obesogen” EDCs accumulate in adipose tissue, and this can lead to interactions and changes in the endocrine activity of adipose tissue and homeostatic systems underlying weight control.…”
Section: Resultsmentioning
confidence: 99%
“…These chemicals can disrupt the development process and may have later pathological consequences such as neurodevelopmental disorders (NDD) (Van de Bor, 2019; Tran and Miyake, 2017). Thus, early life exposure to endocrine disruptors can provoke adulthood harmful consequences (Gluckman et al, 2007; Bernal et al, 2022). Supporting this idea, BPS exposure after weaning seems to create a critical hepatic environment, the impacts of which will become more pronounced and characterized in later life stages (Bernal et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, early life exposure to endocrine disruptors can provoke adulthood harmful consequences (Gluckman et al, 2007; Bernal et al, 2022). Supporting this idea, BPS exposure after weaning seems to create a critical hepatic environment, the impacts of which will become more pronounced and characterized in later life stages (Bernal et al, 2022). This influence will be more pronounced in vulnerable organisms (with genetic differences and/or metabolic disorders) leading, eventually, to advanced liver disease (Chitturi and Farrell, 2001).…”
Section: Discussionmentioning
confidence: 99%
“…More recently, it has been acknowledged that exposure to environmental factors may also promote NAFLD [ 5 ], thus leading to the concepts of TAFLD and TASH (Toxicant-Associated Fatty Liver Diseases and Toxicant-Associated Steatohepatitis) [ 6 , 7 , 8 ]. Among environmental factors, endocrine disrupting compounds (EDCs), also called metabolism disrupting chemicals (MDCs), have been described for their ability to disrupt metabolic functions involved in the development of hepatic steatosis and the progression to steatohepatitis [ 9 , 10 , 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%