Combination of Triple Therapy and Chronic PPI Use May Decrease Risk of Colonic Adenomatous Polyps inHelicobacter pyloriInfection

Abstract

Aim. The aim of the paper is to determine association between H. pylori and colonic adenomatous polyps and to explore whether treatment or chronic PPI use can mitigate this risk. Methods. This case-control study included 943 patients who had H. pylori testing and underwent colonoscopy. Presence of polyps was the outcome of interest, whereas age, sex, race, H. pylori infection, triple therapy, and chronic PPI use were independent variables. Multivariate regression analysis was used to calculate odds ratios at 95% confidence intervals. This study was approved by the New York Medical College Institutional Review Board. Results. H. pylori was associated with increased odds of colonic adenomatous polyps (adjusted OR 1.43, 95% CI 1.04–1.77), with stronger association among patients older than 50 (OR 1.65, 95% CI 1.18–2.33). Triple therapy (OR 0.69, 95% CI 0.44–1.07) or chronic PPI use (OR 0.69, 95% CI 0.43–1.09) decreased odds of polyp formation. Analysis revealed a statistically significant reduction in patients who received both triple therapy and chronic PPI, lowering the odds by 60% (adjusted OR 0.43, 95% CI 0.27–0.67). Conclusion. There is increased risk of colonic adenomatous polyps among H. pylori-infected patients. Triple therapy or chronic PPI use may mitigate this risk, with further reduction when these two interventions are combined.

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma for adults

“…[ 3 , 6 , 8 , 9 , 19 , 21 – 42 ] Nineteen of them are cross-sectional studies, [ 3 , 6 , 8 , 19 , 21 – 24 , 25 – 28 , 30 , 31 , 35 , 37 – 40 ] and the remaining 8 are case–control studies. [ 9 , 29 , 32 – 34 , 36 , 41 , 42 ] Serology was utilized as the detection method for H pylori in 14 studies, [ 8 , 9 , 21 , 23 , 25 – 27 , 31 – 35 , 38 , 39 ] pathology in 4, [ 3 , 22 , 40 , 42 ] urea breath test (UBT) in 4, [ 6 , 37 ] Campylobacter-like organism test (CLO) in 6, [ 19 , 24 , 30 , 36 ] and combining UBT and CLO in 2. [ 28 , 29 ] Gender and age are reported in 22 [ 3 , 6 , 8 , 9 , 19 , 21 – 30 , 34 – 40 ] and 27 [ 3 , 6 , 8 , 9 , 19 , 21 –…”

“…[ 9 , 29 , 32 – 34 , 36 , 41 , 42 ] Serology was utilized as the detection method for H pylori in 14 studies, [ 8 , 9 , 21 , 23 , 25 – 27 , 31 – 35 , 38 , 39 ] pathology in 4, [ 3 , 22 , 40 , 42 ] urea breath test (UBT) in 4, [ 6 , 37 ] Campylobacter-like organism test (CLO) in 6, [ 19 , 24 , 30 , 36 ] and combining UBT and CLO in 2. [ 28 , 29 ] Gender and age are reported in 22 [ 3 , 6 , 8 , 9 , 19 , 21 – 30 , 34 – 40 ] and 27 [ 3 , 6 , 8 , 9 , 19 , 21 – 35 , 37 – 39 , 41 , 42 ] studies, respectively. Most studies were carried out in Asia (7 in Korea, 3 in Taiwan, 3 in Japan, 1 in Thailand, and 1 in China) and the remaining in the Americas (5 in the United States of America and 1 in Brazil) and in Europe (2 in Germany, 1 in Turkey, 1 in Greece, and 1 in Israel).…”

“…All of the eligible studies presented OR for colorectal adenoma related to H pylori infection [3,6,8,9,19,21–42] . Nineteen of them are cross-sectional studies, [3,6,8,19,21–24,25–28,30,31,35,37–40] and the remaining 8 are case–control studies [9,29,32–34,36,41,42] . Serology was utilized as the detection method for H pylori in 14 studies, [8,9,21,23,25–27,31–35,38,39] pathology in 4, [3,22,40,42] urea breath test (UBT) in 4, [6,37] Campylobacter-like organism test (CLO) in 6, [19,24,30,36] and combining UBT and CLO in 2 [28,29] .…”

“…[9,29,[32][33][34]36,41,42] Serology was utilized as the detection method for H pylori in 14 studies, [8,9,21,23,[25][26][27][31][32][33][34][35]38,39] pathology in 4, [3,22,40,42] urea breath test (UBT) in 4, [6,37] Campylobacter-like organism test (CLO) in 6, [19,24,30,36] and combining UBT and CLO in 2. [28,29] Gender and age are reported in 22 [3,6,8,9,19,[21][22][23][24][25][26][27][28][29][30][34][35]…”

Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis

“…Gender and age are reported in 22[3,6,8,9,19,[21][22][23][24][25][26][27][28][29][30][34][35][36][37][38][39][40] and 27[3,6,8,9,19,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][37][38][39]41,42] studies respectively. Most studies were carried out in Asia (7 in Korea, 3 in Taiwan, 3 in Japan, 1 in Thailand and 1 in China) and the remaining in Americas (5 in USA and 1 in Brazil) and in Europe (2 in Germany, 1 in Turkey, 1 in Greece and 1 in Israel).…”