Combination of obesity and co-morbidities leads to unfavorable outcomes in COVID-19 patients

Heialy, Saba Al; Hachim, Mahmood Y.; Hachim, Ibrahim Y.; Naeem, Kashif; Hannawi, Haifa; Lakshmanan, Jeyaseelan; Salmi, Issa Al; Hannawi, Suad

doi:10.1016/j.sjbs.2020.11.081

Cited by 24 publications

(28 citation statements)

References 16 publications

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“…For that reason, enormous efforts were made to improve our understanding of COVID-19 pathogenesis as well as risk factors involved in adverse clinical outcome of the disease in some patients. Indeed, this might lead to the discovery of predictive markers that can identify patients with severe/critical disease who need more aggressive medical interference [ 4 – 11 ]. Indeed, this step is essential for the early management of such patients to improve their outcome and to facilitate the optimal use of the available medical infrastructures and resources [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

Hachim

Hannawi

et al. 2021

PLoS ONE

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Several reports highlighted the central role of inflammation in the pathogenesis of corona virus disease-19 (COVID-19) disease. Also, the hyper-inflammatory response that is triggered by severe acute respiratory syndrom-Covid-2 (SARS-CoV-2) infection was believed to play an essential role in disease severity and adverse clinical course. For that reason, the classical inflammatory markers were proposed as a possible indicator for COVID-19 severity. However, an extensive analysis of the predictive value of inflammatory biomarkers in large patients’ cohorts is still limited and critically needed. In this study we investigated the predictive value of the classical inflammatory biomarkers in a patient cohort consists of 541 COVID-19 patients admitted to Al Kuwait Hospital, Dubai, UAE. A detailed analysis of the association between the essential inflammatory markers and clinical characteristics as well as clinical outcome of the patients were made. In addition, the correlation between those markers and a wide range of laboratory biomarkers and incidence of acute organs injury were investigated. Our results showed a significant elevation of many inflammatory markers including white cell count (WBC) count, neutrophils count, C-reactive protein (CRP), D-Dimer, ferritin, procalcitonin (PCT), and lactate dehydrogenase (LDH) levels in patients with more severe illness. Also, our results highlighted that higher levels of those markers can predict worse patient outcome including the need of ventilation, intensive care unit (ICU) admission, multiple organs dysfunction as well as death. In addition, Our results showed that the presence of lymphopenia and lower absolute lymphocyte count (ALC) at the time of admission were associated with severe to critical COVID-19 illness (P<0.0001), presence of acute respiratory distress syndrome (ARDS) (P<0.0001) and the need for ventilation and ICU admission., Moreover, our results showed a strong association between lower ALC count and multiple organs dysfunction and patient’s death (P<0.0001). In conclusion, our results highlighted the possible use of classical inflammatory biomarkers at time of admission as a potential predictive marker for more severe clinical course in COVID-19 patients that might need more aggressive therapeutic approach including the need of ventilators and ICU admission. The presence of such predictive markers might improve patient’s stratification and help in the direction of the available resources to patients in need, which in turn help in improving our response to the disease pandemic.

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Section: Introductionmentioning

confidence: 99%

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

Hachim

Hannawi

et al. 2021

PLoS ONE

Self Cite

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“…Similarly, for the primary endpoint, i.e. disease severity, a total of seventy reports were included in the meta-analysis 32, 42–110 . These had a combined sample size of 292,165 with 40,272 patients reaching the endpoint of high disease severity (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, a total of 51 studies were included for meta-analysis for the secondary outcome i.e. mortality 42, 45, 46, 48–52, 55, 63, 66, 75, 79, 80, 82, 85, 88, 89, 92, 101, 109, 111–140 . These had a combined sample size of 380,130 with 118,351 patients reaching the endpoint of mortality.…”

Section: Resultsmentioning

confidence: 99%

Association of Obesity with COVID-19 Severity and Mortality: A Systemic Review and Meta-Regression

Singh

Rathore²,

Khan³

et al. 2021

Preprint

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Objective: To estimate the association of obesity with severity (defined as use of invasive mechanical ventilation or intensive care unit admission) and all-cause mortality in coronavirus disease 2019 (COVID-19) patients. Patients and Methods: A systematic search was conducted from inception of COVID-19 pandemic through January 31st, 2021 for full-length articles focusing on the association of increased BMI/ Obesity and outcome in COVID-19 patients with help of various databases including Medline (PubMed), Embase, Science Web, and Cochrane Central Controlled Trials Registry. Preprint servers such as BioRxiv, MedRxiv, ChemRxiv, and SSRN were also scanned. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used for study selection and data extraction. The severity in hospitalized COVID-19 patients, such as requirement of invasive mechanical ventilation and intensive care unit admission with high BMI/ Obesity was the chief outcome. While all-cause mortality in COVID-19 hospitalized patients with high BMI/ Obesity was the secondary outcome. Results: A total of 576,784 patients from 100 studies were included in this meta-analysis. Being obese was associated with increased risk of severe disease (RR=1.46, 95% CI 1.34-1.60, p<0.001, I2 = 92 %). Similarly, high mortality was observed in obese patients with COVID-19 disease (RR=1.12, 95% CI 1.06-1.19, p<0.001, I2 = 88%). In a multivariate meta-regression on severity outcome, the covariate of female gender, pulmonary disease, diabetes, older age, cardiovascular diseases, and hypertension was found to be significant and explained R2= 50% of the between-study heterogeneity for severity. Similarly, for mortality outcome, covariate of female gender, proportion of pulmonary disease, diabetes, hypertension, and cardiovascular diseases were significant, these covariates collectively explained R2=53% of the between-study variability for mortality. Conclusions: Our findings suggest that obesity is significantly associated with increased severity and higher mortality among COVID-19 patients. Therefore, the inclusion of obesity or its surrogate body mass index in prognostic scores and streamlining the management strategy and treatment guidelines to account for the impact of obesity in patient care management is recommended.

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“…During the pandemic, promotion of physical activity and prevention of obesity are as important as physical isolation of severely obese individuals [18]. Physical activity, maternal prenatal diet, psychological stress, sleep quality, and oxidative stress promoting disease conditions are important modulators of obesity and oxidative stress [19,20]. Obesity in individuals with COVID-19 independently has a relationship with increased risk for ICU admission and intubation [21,22].…”

Section: Introductionmentioning

confidence: 99%

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

2021

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Overweight and obesity have become global epidemics, especially during the lockdown due to the COVID-19 pandemic. The potential of medicinal plants as a better and safe option in treating obesity and overweight has gained attention in recent years. Obesity and overweight has become a major public health concern, and its incidence rising at an alarming rate. Obesity is one of the major types of metabolic syndrome, resulting in various types of problems such as hypertension, diabetes, dyslipidemia, and excess fat accumulation. The current searching was done by the keywords in main indexing systems including Scopus, PubMed/MEDLINE, the search engine of Google Scholar, and Institute for Scientific Web of Science. The keywords were traditional medicine, health benefits, pharmaceutical science, pomegranate, punicalin, punicalagin, and ellagitannins. Google Scholar was searched manually for possible missing manuscripts, and there was no language restriction in the search. This review was carried out to highlight the importance of medicinal plants which are common in traditional medicinal sciences of different countries, especially Asia to prevent and treatment of obesity and overweight during the global pandemic and the post-COVID-19 era.

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Combination of obesity and co-morbidities leads to unfavorable outcomes in COVID-19 patients

Cited by 24 publications

References 16 publications

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

Association of Obesity with COVID-19 Severity and Mortality: A Systemic Review and Meta-Regression

Natural Dietary and Medicinal Plants with Anti-Obesity Therapeutics Activities for Treatment and Prevention of Obesity during Lock Down and in Post-COVID-19 Era

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