Combination of mesenchymal stem cells and bioactive molecules in hydrogels for osteoarthritis treatment

Gonzalez-Fernandez, Paula; Rodríguez-Nogales, Carlos; Jordan, Olivier; Allémann, Éric

doi:10.1016/j.ejpb.2022.01.003

Cited by 23 publications

(10 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated that MSCs exert critical immunomodulatory roles in cartilage regeneration, mainly through paracrine secretion of trophic factors [ 224 – 226 ]. However, the immunomodulatory function of MSCs cannot be sufficiently imitated by any cytokine alone, e.g., IL-6, IL-8, IL-10, IL-33, monocyte chemoattractant protein-1 (MCP-1), or TGF-β, thus indicating that the immunomodulatory function of MSCs necessitates synergism among multiple cytokines [ 227 , 228 ]. MSC-derived sEVs loaded with more than 100 immunomodulatory proteins are considered a perfect vehicle for this synergism [ 229 ].…”

Section: Roles Of Sevs-derived Immunomodulation In Tissue Regenerationmentioning

confidence: 99%

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Xiong

Lin

et al. 2022

Military Med Res

View full text Add to dashboard Cite

Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding of the immune microenvironment processes governing bone, cartilage, and soft tissue regeneration, effective clinical translation of these mechanisms remains a challenge. Regulation of the immune microenvironment is increasingly becoming a favorable target for bone, cartilage, and soft tissue regeneration; therefore, an in-depth understanding of the communication between immune cells and functional tissue cells would be valuable. Herein, we review the regulatory role of the immune microenvironment in the promotion and maintenance of stem cell states in the context of bone, cartilage, and soft tissue repair and regeneration. We discuss the roles of various immune cell subsets in bone, cartilage, and soft tissue repair and regeneration processes and introduce novel strategies, for example, biomaterial-targeting of immune cell activity, aimed at regulating healing. Understanding the mechanisms of the crosstalk between the immune microenvironment and regeneration pathways may shed light on new therapeutic opportunities for enhancing bone, cartilage, and soft tissue regeneration through regulation of the immune microenvironment.

show abstract

Section: Roles Of Sevs-derived Immunomodulation In Tissue Regenerationmentioning

confidence: 99%

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Xiong

Lin

et al. 2022

Military Med Res

View full text Add to dashboard Cite

show abstract

“…MSCs are undifferentiated pluripotent stem cells characterized by the ability to self-renew when exposed to specific growth signals ( Mohamed-Ahmed et al, 2018 ; Gonzalez-Fernandez et al, 2022 ). MSCs could differentiate into chondrocytes, osteoblasts, muscle cells, and adipose cells, providing great potential for cartilage tissue engineering.…”

Section: Materials Of Injectable Hydrogelsmentioning

confidence: 99%

Advanced injectable hydrogels for cartilage tissue engineering

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The rapid development of tissue engineering makes it an effective strategy for repairing cartilage defects. The significant advantages of injectable hydrogels for cartilage injury include the properties of natural extracellular matrix (ECM), good biocompatibility, and strong plasticity to adapt to irregular cartilage defect surfaces. These inherent properties make injectable hydrogels a promising tool for cartilage tissue engineering. This paper reviews the research progress on advanced injectable hydrogels. The cross-linking method and structure of injectable hydrogels are thoroughly discussed. Furthermore, polymers, cells, and stimulators commonly used in the preparation of injectable hydrogels are thoroughly reviewed. Finally, we summarize the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.

show abstract

“…As such, patients often experience variable levels of pain and disability, and much research and clinical trial effort have focused on hip and knee OA. However, after spending billions of research dollars and much effort over the past decades, there are currently no effective treatments to stop disease progression in the broad base of patients, and certainly, no treatments that can reverse the joint damage incurred as a consequence of the OA are available [ 10 , 11 ]. Such lack of progress has been discouraging for both the millions of patients with the disease, as well as companies that have invested heavily in research programs.…”

Section: Subsets Of Knee Osteoarthritismentioning

confidence: 99%

“…While the term osteoarthritis implies that the degenerative process involves inflammation, for many years it was considered solely a degenerative process ascribed to aging-related “wear and tear” or due to injury that disturbed the relationship between the components of a joint leading to the demise of the “weakest link”-cartilage [ 7 ]. However, it is now fairly clear that inflammatory processes are involved in OA progression [ 4 , 8 , 9 , 10 , 11 , 12 ], but it is not clear whether inflammation is part of the initiation process leading to overt OA in different subsets of the condition.…”

Section: Introductionmentioning

confidence: 99%

Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies

Hart

2022

IJMS

View full text Add to dashboard Cite

Osteoarthritis (OA) of joints such as the knee and hip are very prevalent, and the number of individuals affected is expected to continue to rise. Currently, conservative treatments after OA diagnosis consist of a series of increasingly invasive interventions as the degeneration and pain increase, leading very often to joint replacement surgery. Most interventions are focused on alleviating pain, and there are no interventions currently available that stop and reverse OA-associated joint damage. For many decades OA was considered a disease of cartilage, but it is now considered a disease of the whole multi-tissue joint. As pain is the usual presenting symptom, for most patients, it is not known when the disease process was initiated and what the basis was for the initiation. The exception is post-traumatic OA which results from an overt injury to the joint that elevates the risk for OA development. This scenario leads to very long wait lists for joint replacement surgery in many jurisdictions. One aspect of why progress has been so slow in addressing the needs of patients is that OA has been used as an umbrella term that does not recognize that joint degeneration may arise from a variety of mechanistic causes that likely need separate analysis to identify interventions unique to each subtype (post-traumatic, metabolic, post-menopausal, growth and maturation associated). A second aspect of the slow pace of progress is that the bulk of research in the area is focused on post-traumatic OA (PTOA) in preclinical models that likely are not clearly relevant to human OA. That is, only ~12% of human OA is due to PTOA, but the bulk of studies investigate PTOA in rodents. Thus, much of the research community is failing the patient population affected by OA. A third aspect is that conservative treatment platforms are not specific to each OA subset, nor are they integrated into a coherent fashion for most patients. This review will discuss the literature relevant to the issues mentioned above and propose some of the directions that will be required going forward to enhance the impact of the research enterprise to affect patient outcomes.

show abstract

Combination of mesenchymal stem cells and bioactive molecules in hydrogels for osteoarthritis treatment

Cited by 23 publications

References 135 publications

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Advanced injectable hydrogels for cartilage tissue engineering

Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies

Contact Info

Product

Resources

About