Search citation statements

Order By: Relevance
Select...
2
1
1
0
17
0

Year Published

2008
2008
2012
2012

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

0
17
0
Order By: Relevance
“…Others have previously found that inhibition of αv-integrins may affect primary tumor growth and increase sensitivity to IR (45). Our study indicates that the primary tumor cell survival signaling may also be targeted using ATN-161, resulting in downregulation of α5β1-integrin through the suppression of Akt activity, which has been implicated in cell survival by inhibiting apoptosis (46).…”
Section: Discussionmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 100,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Others have previously found that inhibition of αv-integrins may affect primary tumor growth and increase sensitivity to IR (45). Our study indicates that the primary tumor cell survival signaling may also be targeted using ATN-161, resulting in downregulation of α5β1-integrin through the suppression of Akt activity, which has been implicated in cell survival by inhibiting apoptosis (46).…”
Section: Discussionmentioning
“…Currently, patients with melanoma and glioblastoma multiforme benefit from Vitaxin (MedImmune) or cilengitide treatment, respectively (22). Small interfering RNAs that specifically silence integrin a v and/or h 3 have been reported to cause tumor shrinkage in preclinical xenograft models (23). Combinations of anti-integrin a v h 3 therapy and other therapeutic approaches (such as chemotherapy, radiotherapy, and gene therapy) have also been applied to cancer treatment (24).…”
Section: Introductionmentioning
“…Combination therapy with α v β 3 integrin antagonists appears beneficial in local tumor therapy [9]. Similarly, Cao et al have demonstrated that the combination of α V siRNA and irradiation leads to increased radiosensitivity [10]. Investigators have demonstrated that β 1 -integrin-mediated signaling through cytoplasmic domains is critical for efficient cell survival after radiation therapy [11].…”
Section: Cell Adhesionmentioning