Combination chemotherapy for high-risk gestational trophoblastic tumour

Chemo-resistant gestational trophoblastic neoplasia, 5-years experience of Mansoura University Hospital, Egypt

“…High risk cases received MAC combination chemo-therapy, however, 60% of them were resistant to this protocol. This figure was higher than reports of other authors [10,12], this can be explained by smaller number of patients in the current study. In this study, we tried to determine whether there were any factors linked to resistance to first line chemotherapy during initial treatment of GTN.…”

Chemo-resistant gestational trophoblastic neoplasia, 5-years experience of Mansoura University Hospital, Egypt

“…High risk cases received MAC combination chemo-therapy, however, 60% of them were resistant to this protocol. This figure was higher than reports of other authors [10,12], this can be explained by smaller number of patients in the current study. In this study, we tried to determine whether there were any factors linked to resistance to first line chemotherapy during initial treatment of GTN.…”

Successful Pregnancy after Choriocarcinoma

“…2 As our patient turned out to be resistant to single agent (MTX) chemotherapy, we had to switch over to combination chemotherapy. 3,4 Combined chemotherapy is commonly used in gynaecologic cancer so as to overcome resistance by tumor cells by choosing drugs with different mechanisms of action and also to reduce overlapping toxicity. Proper counselling regarding meticulous follow up is an essential part of managing choriocarcinoma.…”

Coexistent molar pregnancy with a normal fetus-a rare presentation of gestational trophoblastic disease

“…The second most common site of metastasis is the vagina, around 30% of cases. 14 Earlystage gestational trophoblastic neoplasia is often cured with single-agent chemotherapy, but the advanced stage needs multi-agent combination chemotherapeutic regimens. 14 In most cases, gestational trophoblastic neoplasia following twin pregnancy with a complete mole can be adequately treated with single-agent methotrexate.…”

“…14 Earlystage gestational trophoblastic neoplasia is often cured with single-agent chemotherapy, but the advanced stage needs multi-agent combination chemotherapeutic regimens. 14 In most cases, gestational trophoblastic neoplasia following twin pregnancy with a complete mole can be adequately treated with single-agent methotrexate. 2,10 If the diagnosis is still suspected and continuation of pregnancy is desired, fetal karyotype should be obtained, chest radiography should be performed to screen for metastases, and serial serum beta-hCG values should be followed.…”

Chemo-resistant gestational trophoblastic neoplasia, 5-years experience of Mansoura University Hospital, Egypt

“…High risk cases received MAC combination chemo-therapy, however, 60% of them were resistant to this protocol. This figure was higher than reports of other authors [10,12], this can be explained by smaller number of patients in the current study. In this study, we tried to determine whether there were any factors linked to resistance to first line chemotherapy during initial treatment of GTN.…”

Successful Pregnancy after Choriocarcinoma

“…2 As our patient turned out to be resistant to single agent (MTX) chemotherapy, we had to switch over to combination chemotherapy. 3,4 Combined chemotherapy is commonly used in gynaecologic cancer so as to overcome resistance by tumor cells by choosing drugs with different mechanisms of action and also to reduce overlapping toxicity. Proper counselling regarding meticulous follow up is an essential part of managing choriocarcinoma.…”

Coexistent molar pregnancy with a normal fetus-a rare presentation of gestational trophoblastic disease

“…The second most common site of metastasis is the vagina, around 30% of cases. 14 Earlystage gestational trophoblastic neoplasia is often cured with single-agent chemotherapy, but the advanced stage needs multi-agent combination chemotherapeutic regimens. 14 In most cases, gestational trophoblastic neoplasia following twin pregnancy with a complete mole can be adequately treated with single-agent methotrexate.…”

“…14 Earlystage gestational trophoblastic neoplasia is often cured with single-agent chemotherapy, but the advanced stage needs multi-agent combination chemotherapeutic regimens. 14 In most cases, gestational trophoblastic neoplasia following twin pregnancy with a complete mole can be adequately treated with single-agent methotrexate. 2,10 If the diagnosis is still suspected and continuation of pregnancy is desired, fetal karyotype should be obtained, chest radiography should be performed to screen for metastases, and serial serum beta-hCG values should be followed.…”

Chemo-resistant gestational trophoblastic neoplasia, 5-years experience of Mansoura University Hospital, Egypt

“…High risk cases received MAC combination chemo-therapy, however, 60% of them were resistant to this protocol. This figure was higher than reports of other authors [10,12], this can be explained by smaller number of patients in the current study. In this study, we tried to determine whether there were any factors linked to resistance to first line chemotherapy during initial treatment of GTN.…”

Successful Pregnancy after Choriocarcinoma

“…2 As our patient turned out to be resistant to single agent (MTX) chemotherapy, we had to switch over to combination chemotherapy. 3,4 Combined chemotherapy is commonly used in gynaecologic cancer so as to overcome resistance by tumor cells by choosing drugs with different mechanisms of action and also to reduce overlapping toxicity. Proper counselling regarding meticulous follow up is an essential part of managing choriocarcinoma.…”

Coexistent molar pregnancy with a normal fetus-a rare presentation of gestational trophoblastic disease

“…The second most common site of metastasis is the vagina, around 30% of cases. 14 Earlystage gestational trophoblastic neoplasia is often cured with single-agent chemotherapy, but the advanced stage needs multi-agent combination chemotherapeutic regimens. 14 In most cases, gestational trophoblastic neoplasia following twin pregnancy with a complete mole can be adequately treated with single-agent methotrexate.…”

“…14 Earlystage gestational trophoblastic neoplasia is often cured with single-agent chemotherapy, but the advanced stage needs multi-agent combination chemotherapeutic regimens. 14 In most cases, gestational trophoblastic neoplasia following twin pregnancy with a complete mole can be adequately treated with single-agent methotrexate. 2,10 If the diagnosis is still suspected and continuation of pregnancy is desired, fetal karyotype should be obtained, chest radiography should be performed to screen for metastases, and serial serum beta-hCG values should be followed.…”