Infectious Disease Clinics of North America volume 23, issue 2, P277-293 2009 DOI: 10.1016/j.idc.2009.01.004 View full text
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Mical Paul, Leonard Leibovici

Abstract: Systematic reviews and meta-analyses have put into perspective the clinical implications of in vitro synergy (Box 1). Randomized, controlled trials are the cornerstone of evidence-based medicine. The trials included in the meta-analyses described in this article are the building blocks of evidence. Individual trials, however, were individually underpowered to address the broader clinical question and relevant patient-related outcomes. On the question of combination therapy, meta-analyses have shaped the comple…

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