Colostrum Protein Concentrate Enhances Intestinal Adaptation After Massive Small Bowel Resection in Juvenile Pigs

Nagy, Éva; Paris, M.C.J.; Taylor, Russell G.; Fuller, Peter J.; Sourial, Magdy; Justice, Fran; Bines, Julie E

doi:10.1097/00005176-200411000-00008

Cited by 41 publications

(63 citation statements)

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“…The sham group also had a significantly lower mean weight than the NOC group at the five-week and six-week time-points (p = 0.041 and p < 0.0001). 18 Examination of feed intake showed that, although piglets in the SBR group consumed equal energy per kg per day, their total energy consumption was reduced when compared with the NOC and sham groups due to their decreased weight. Piglets in the SBR group failed to resolve diarrhea at either the two-week (p = 0.002 and p = 0.005) or sixweek (p < 0.0001) time-points (Fig.…”

Section: Resultsmentioning

confidence: 99%

Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome

et al. 2013

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IntroductionShort bowel syndrome (SBS) is the clinical state of malabsorption and malnutrition that occurs following small bowel resection (SBR). 1 Surgical resection of the small bowel may be required for the treatment of a range of conditions including congenital bowel abnormalities and necrotising enterocolitis in children and Crohn disease, trauma and malignancy in adults. Although the underlying reason for SBR between adults and children may differ, the clinical manifestations and consequences of SBS are similar. The symptoms of SBS reflect the loss of absorptive surface area and functional disturbance of the Background and objectives: Following small bowel resection (sBR), the luminal environment is altered, which contributes to clinical manifestations of short bowel syndrome (sBs) including malabsorption, mucosal inflammation and bacterial overgrowth. however, the impact of sBR on the colon has not been well-defined. The aims of this study were to characterize the colonic microbiota following sBR and to assess the impact of sBR on mucosal inflammation in the colon.Results: analysis of the colonic microbiota demonstrated that there was a significant level of dysbiosis both two and six weeks post-sBR, particularly in the phylum Firmicutes, coupled with a decrease in overall bacterial diversity in the colon. This decrease in diversity was associated with an increase in colonic inflammation six weeks post-surgery.Methods: Female (4-week old) piglets (5-6/group) received a 75% sBR, a transection (sham) or no surgery. compositional analysis of the colonic microbiota was performed by high-throughput sequencing, two-and six-weeks post-surgery. The gene expression of the pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, IL-18 and tumor necrosis factor (TNF)-α in the colonic mucosa was assessed by qRT-pcR and the number of macrophages and percentage inducible nitric oxide synthase (iNOs) staining in the colonic epithelium were quantified by immunohistochemistry.Conclusions: sBR significantly decreased the diversity of the colonic microbiota and this was associated with an increase in colonic mucosal inflammation. This study supports the hypothesis that sBR has a significant impact on the colon and that this may play an important role in defining clinical outcome.

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Section: Resultsmentioning

confidence: 99%

Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome

et al. 2013

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“…The majority of studies used domestic pigs or piglets [5,13,16,17,18,19] mainly of female gender [10,13,16,18,20,21,22,23,24,25,26,27,28,29]. Regarding the exact breed, mostly landrace [10,21,22,30,31] or landrace × large white [5,13,16,20,24,26,32,33,34] animals were used.…”

Section: Resultsmentioning

confidence: 99%

Models of Short Bowel Syndrome in Pigs: A Technical Review

Weih

Nickkholgh²,

Keßler³

et al. 2013

Eur Surg Res

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Background: Short bowel syndrome (SBS) is still a life-threatening disease in both children and adults. Although the therapeutic options are improving, challenges still remain, and to overcome these challenges is a major focus of SBS research today. In order to simulate anatomical and physiological conditions similar to those in humans for research, porcine models of SBS are often used. Various approaches for generating SBS models have been described in the literature. Methods/Results: In this work, we present a review of different types of porcine models of SBS and outline the differences between those models regarding types of animals, surgical procedures, monitoring, and methods of assessment. Conclusion: The aim of this study was to select the most suitable SBS model regarding the purpose of the research.

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“…Colostrum supplement induces muscular hypertrophy increasing the muscle width and the number of cells and these changes may be mediated by the simultaneous increase of the serum concentrations of IGF-1 and IGF binding proteins after small intestinal resection in piglets (176). In a pig model of SBS colostrum induced intestinal adaptation, the piglets that underwent massive intestinal resection showed the same weight gain and greater villus length and crypt depth in the jejunum and ileum compared to the control (177). On the contrary, in a randomized controlled trial Lund et al, observed that in spite of it high content of bioactive factors, colostrum did not significantly increase intestinal functions, absorption and body composition compared with the control (178).…”

Section: Short Bowel Syndrome (Sbs)mentioning

confidence: 97%

Potential benefits of colostrum in gastrointestinal diseases

et al. 2016

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Colostrum Protein Concentrate Enhances Intestinal Adaptation After Massive Small Bowel Resection in Juvenile Pigs

Abstract: In an animal model of SBS, CPC supplementation of polymeric infant formula resulted in normal weight gain and features of enhanced morphologic adaptation.

Cited by 41 publications

References 29 publications

Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome

Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome

Models of Short Bowel Syndrome in Pigs: A Technical Review

Potential benefits of colostrum in gastrointestinal diseases

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