Colorimetric detection of cyanide with phenyl thiourea derivatives

Lin, Yi-Shan; Zheng, Jia-Xing; Tsui, Yao-Kang; Yen, Yao‐Pin

doi:10.1016/j.saa.2011.04.087

Cited by 30 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…50 However, many receptors for CN À ions reported thus far have several limitations such as poor selectivity over F À or OAc À , and utilization of expensive chemicals, complicated synthesis, and working only in organic media. 51,52 Therefore, the search for successful and selective cyanide-sensing systems in aqueous environments is still required.…”

Section: Introductionmentioning

confidence: 99%

A novel dihydro phenylquinazolinone-based two-in-one colourimetric chemosensor for nickel(ii), copper(ii) and its copper complex for the fluorescent colourimetric nanomolar detection of the cyanide anion

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

A novel dihydro phenylquinazolinone-based two-in-one colourimetric chemosensor for nickel(ii), copper(ii) and its copper complex for the fluorescent colourimetric nanomolar detection of the cyanide anion

et al. 2020

View full text Add to dashboard Cite

show abstract

“…2 ; refs. 32–34). However, the physiological proteolysis that sustains this mechanism has not been yet identified (34–36).…”

Section: Resultsmentioning

confidence: 99%

Angiogenesis stimulated by human kallikrein‐related peptidase 12 actingviaa platelet‐derived growth factor B‐dependent paracrine pathway

et al. 2013

View full text Add to dashboard Cite

KLK12, a kallikrein peptidase, is thought to take part in the control of angiogenesis. Our analysis of the secretome of endothelial cells (ECs) that had been treated with KLK12 showed that KLK12 converts the extracellular matrix- or membrane-bound precursor of platelet-derived growth factor B (PDGF-B) into a soluble form. Both PDGF-B and vascular endothelial growth factor A (VEGF-A) take part in the induction of angiogenesis by KLK12 in a coculture model of angiogenesis that mimics endothelial tubule formation. We used a cellular approach to analyze the interplay between KLK12, PDGF-B, and VEGF-A and showed that release of PDGF-B by KLK12 leads to the fibroblast-mediated secretion of VEGF-A. This then stimulates EC differentiation and the formation of capillary tube-like structures. Thus, KLK12 favors the interaction of ECs and stromal cells. The released PDGF-B acts as a paracrine factor that modulates VEGF-A secretion by stromal cells, which ultimately leads to angiogenesis. Moreover, the genes encoding KLK12 and PDGFB are both expressed in ECs and up-regulated in tumor cells kept under hypoxic conditions, which is consistent with the physiological involvement of KLK12 in PDGF-B maturation.

show abstract

“…These reactions are demonstrated in displacement at metals; copper [24][25][26][27], boron [28], cobalt [10,29] and iron [30]. Addition reaction like conjugate addition to enone [26,31] by Michael-type addition [32][33][34], addition to aldehydes [22,28,[35][36][37], ketones [38][39][40], amides [4,41,42], iminium ions [23,[43][44][45][46] and thiourea [47,48]. Many of these methods exhibited limitations of poor selectivity and incompatibility in aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%

Selective colorimetric molecular probe for cyanide ion detection in aqueous solution

et al. 2018

View full text Add to dashboard Cite

5-Nitro-2-hydroxybenzaldehyde (1) demonstrated to be a sensitive, and a selective molecular probe for cyanide ion (CN-) in aqueous media. In acetonitrile, compound 1 shows sensitivity and selectivity for cyanide, acetate and fluoride, in comparison to other investigated anions using both visual and spectroscopic means. In aqueous solution, the color becomes intense yellow upon addition of cyanide, while acetate showed this effect to a much lower extent. Significant spectral changes were also detected with the appearance of two new absorption bands at 358 and 387 nm. This was accompanied by concomitant intensity decrease for the band at 314 nm. Fluoride, dihydrogen phosphate, chloride, bromide, perchlorate, and azide showed negligible color and spectral changes for the probe in aqueous solutions. On the other hand, hydrogen sulfate caused fainting of the yellow color and gave a spectrum similar to that of the sensor in polar aprotic solvents. The cyanide ion was detected at micro molar levels in aqueous solutions with a stoichiometry of 1:1 for CN: probe in acetonitrile as the solvent. Cyanide, hydroxide, acetate, fluoride and dihydrogen phosphate showed identical changes to color and spectra, indicating a hydrogen bonding and a deprotonation mechanism.

show abstract

Colorimetric detection of cyanide with phenyl thiourea derivatives

Cited by 30 publications

References 38 publications

A novel dihydro phenylquinazolinone-based two-in-one colourimetric chemosensor for nickel(ii), copper(ii) and its copper complex for the fluorescent colourimetric nanomolar detection of the cyanide anion

A novel dihydro phenylquinazolinone-based two-in-one colourimetric chemosensor for nickel(ii), copper(ii) and its copper complex for the fluorescent colourimetric nanomolar detection of the cyanide anion

Angiogenesis stimulated by human kallikrein‐related peptidase 12 actingviaa platelet‐derived growth factor B‐dependent paracrine pathway

Selective colorimetric molecular probe for cyanide ion detection in aqueous solution

Contact Info

Product

Resources

About