Colorectal Cancer in Young Patients in Israel: A Distinct Clinicopathological Entity?

Shemesh-Bar, Lital; Kundel, Yulia; Idelevich, Efraim; Sulkes, Jaqueline; Sulkes, Aarón; Brenner, Baruch

doi:10.1007/s00268-010-0748-1

Cited by 17 publications

(11 citation statements)

References 25 publications

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“…Second, as opposed to some large registry-based studies, which might lack important data, we extracted very detailed clinical data from the patients’ individual medical files. Third, in contrast to other studies evaluating elderly patients with CRC which included much lower age cut-off[ 9 , 10 , 12 , 13 , 19 , 27 , 34 , 38 ], this study’s cut-off probably might highlighted the differences between older and the younger population better.…”

Section: Discussionmentioning

confidence: 81%

Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

Goldvaser

Shroitman

Ben‐Aharon

et al. 2017

WJG

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AIMTo characterize colorectal cancer (CRC) in octogenarians as compared with younger patients.METHODSA single-center, retrospective cohort study which included patients diagnosed with CRC at the age of 80 years or older between 2008-2013. A control group included consecutive patients younger than 80 years diagnosed with CRC during the same period. Clinicopathological characteristics, treatment and outcome were compared between the groups. Fisher’s exact test was used for dichotomous variables and χ2 was used for variables with more than two categories. Overall survival was assessed by Kaplan-Meier survival analysis, with the log-rank test. Cancer specific survival (CSS) and disease-free survival were assessed by the Cox proportional hazards model, with the Fine and Gray correction for non-cancer death as a competing risk.RESULTSThe study included 350 patients, 175 patients in each group. Median follow-up was 40.2 mo (range 1.8-97.5). Several significant differences were noted. Octogenarians had a higher proportion of Ashkenazi ethnicity (64.8% vs 47.9%, P < 0.001), a higher rate of personal history of other malignancies (22.4% vs 13.7%, P = 0.035) and lower rates of family history of any cancer (36.6% vs 64.6%, P < 0.001) and family history of CRC (14.4% vs 27.3%, P = 0.006). CRC diagnosis by screening was less frequent in octogenarians (5.7% vs 20%, P < 0.001) and presentation with performance status (PS) of 0-1 was less common in octogenarians (71% vs 93.9%, P < 0.001). Octogenarians were more likely to have tumors located in the right colon (45.7% vs 34.3%, P = 0.029) and had a lower prevalence of well differentiated histology (10.4% vs 19.3%, P = 0.025). They received less treatment and treatment was less aggressive, both in patients with metastatic and non-metastatic disease, regardless of PS. Their 5-year CSS was worse (63.4% vs 77.6%, P = 0.009), both for metastatic (21% vs 43%, P = 0.03) and for non-metastatic disease (76% vs 88%, P = 0.028).CONCLUSIONOctogenarians presented with several distinct characteristics and had worse outcome. Further research is warranted to better define this growing population.

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Section: Discussionmentioning

confidence: 81%

Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

Goldvaser

Shroitman

Ben‐Aharon

et al. 2017

WJG

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“…Of course some studies demonstrated that, in younger ages, the cancer is presented with different features (anatomical site, stage of tumor, etc. ), but young age by itself was not found to impact patient outcome [16, 18]. …”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer in Northwestern Iran

Mahmodlou

Mohammadi

Sepehrvand

2012

ISRN Gastroenterology

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Background. Colorectal cancer is the third most prevalent cancer worldwide, which is less common in the Middle East; its prevalence demonstrated to be 7 persons per 100,000 populations in Iran. In this study, we aimed to investigate the clinicopathologic features of CRC patients in West Azerbaijan province of Iran. Methods. In this crosssectional study, 546 patients who underwent surgical procedures with the pathologic diagnosis of colorectal cancer in both academic and private hospitals of Urmia were enrolled. Results. The mean age at diagnosis was 55.2 ± 11.5 years. 23% had an age lower than forty years old. Rectal bleeding (26%), abdominal pain (25%), and large bowel obstruction (23%) were three most common presenting symptoms. 26% of patients presented with acute abdomen. 95% of tumors were adenocarcinoma, 4% were lymphoma, and 1% was other rare tumors. Regarding the stage of cancer according to TNM staging system, 6% of patients were in stage I, followed by 37% in stage II, 33% in stage III, and 24% in stage IV. In 44.5% of patients, the tumor was located in rectum. Conclusion. In west Azerbaijan province of Iran, patients with colorectal cancer present in younger age and more advanced stages in comparison with the developed countries.

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“…Second, as opposed to some large registrybased studies, which might lack important data, we extracted very detailed clinical data from the patients' individual medical files. Third, in contrast to other studies evaluating elderly patients with CRC which included much lower age cutoff [9,10,12,13,19,27,34,38] , this study's cutoff probably might highlighted the differences between older and the younger population better.…”

Section: Discussionmentioning

confidence: 61%

Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity.

Goldvaser¹,

Shroitman

Ben‐Aharon

et al. 2017

JCO

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Colorectal Cancer in Young Patients in Israel: A Distinct Clinicopathological Entity?

Abstract: Colorectal cancer in young patients was found to display a cluster of unique characteristics but fewer than previously reported and young age by itself was not found to impact patient outcome.

Cited by 17 publications

References 25 publications

Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity

Colorectal Cancer in Northwestern Iran

Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity.

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