Color vision impairments in schizophrenia and the role of antipsychotic medication type

Fernandes, Thiago Monteiro Paiva; Silverstein, Steven M.; Butler, Pamela D.; Kéri, Szabolcs; Santos, Lucas Galdino Bandeira; Nogueira, Renata L.; Santos, Natanael Antônio dos

doi:10.1016/j.schres.2018.09.002

Cited by 38 publications

(24 citation statements)

References 36 publications

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“…In general, SCZ patients perform worse than healthy controls in most visual tests, including contrast detection (Cadenhead et al, 2013;Fernandes et al, 2018d;Kiss et al, 2010;Shoshina et al, 2015, Slaghuis, 1998) and visual backward masking (Braff, 1981;Chkonia et al, 2010;Green et al 1994;review: Herzog and Brand, 2015). Very little is known to what extent the visual deficits depend on medication.…”

Section: Introductionmentioning

confidence: 99%

“…The exclusion criteria for SCZ patients were: (a) presence of neurological disorders, such as intellectual disability, (b) presence of comorbidities, such as depression or multiple diagnoses, (c) changes in medication in the last 6 months, (d) discontinuation of medication at any time, and (e) chronic heavy smoking (Fernandes et al, 2018c) as assessed by the Fagerström Test for Nicotine Dependence (score > 6; Heatherton et al, 1991). This information was obtained from a continuous study of the medical records (Fernandes et al, 2018d).…”

Section: Introductionmentioning

confidence: 99%

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Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Fernandes

Shaqiri

Brand

et al. 2019

Psychiatry Research

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Fernandes

Shaqiri

Brand

et al. 2019

Psychiatry Research

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“…In view of this, the Metropsis software was developed to provide a comprehensive evaluation of the CSF in retinal, cortical and subcortical populations. The Metropsis vision testing has been used in several studies [12,[15][16][17][18][19]. Despite reliable results, the effects of eye dominance, sample size and repeatability of Metropsis have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Spatial contrast sensitivity: effects of reliability, test–retest repeatability and sample size using the Metropsis software

Fernandes

Almeida

Butler

et al. 2019

Eye

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Purpose The goals of the study were to further assess contrast sensitivity to (1) investigate the existence of monocular vs. binocular differences; (2) observe possible differences between sample sizes; (3) investigate the effects of test-retest repeatability. Methods Contrast sensitivity measurements were obtained by presenting eight horizontal sine-wave gratings (ranging from 0.2 to 20 cycles per degree). A three-up-one-down method was used to obtain thresholds with a criterion of 79.4% correct responses for each spatial frequency. The mean of 12 reversals was used for obtaining thresholds, and the two-alternative forced-choice method was used. Data were recorded in 55 naive observers from 20 to 45 years. All participants were free from identifiable ocular disease and had normal visual acuity. Results We observed the absence of differences on CSF for both monocular and binocular observers, as well as the absence of differences between large sample sizes. The latter investigation revealed a high degree of repeatability across time (baseline to 6 months later) with the higher test-retest for low and high spatial frequencies. Conclusions Our results indicated that spatial contrast sensitivity measurements were little influenced by variables, such as binocular summation, eye dominance, sample size and time using the Metropsis test. The results obtained here have significance for basic and clinical vision science.

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“…It has been demonstrated that the dopamine neurotransmitter system plays a major role in visual functions such as contrast sensitivity and color perception ( 30 ). Contrast sensitivity and color perception are affected in diseases with dopaminergic issues such as Parkinson’s disease, but also in schizophrenia ( 31 ). Therefore, thinning of the RNFL has been attributed to the possible dopamine dysregulation ( 24 , 25 ).…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

The Use of Electroretinography and Optical Coherence Tomography in Patients with Schizophrenia

Duraković

Silić

Peitl

et al. 2020

ACC

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The use of electroretinography (ERG) and optical coherence tomography (OCT) has currently expanded beyond ophthalmology alone. The aim of this review is to present the results and knowledge acquired by these two methods in patients suffering from schizophrenia. Reviewing the studies applying ERG and OCT methods in the field of psychiatry, one can conclude that results of the research imply morphological and functional changes of retina in patients with schizophrenia that are not consistent. However, in most studies there was reduction of the amplitude and changes in the implicit time related parameters on ERG and thinning of the retinal nerve fiber layer on OCT. Neurons in the eye use the same neurotransmitters as neurons in the basal brain structures that are most affected in schizophrenia, according to the dopamine hypothesis of schizophrenia. Unlike neurons in the basal brain structures, the neurons in the eye are in vivo available to ERG. Using the aforementioned tests together with clinical diagnostic criteria of schizophrenia, the subgroups with different prognostic and therapeutic specificities within schizophrenia as a group of diseases might be identified more precisely.

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Color vision impairments in schizophrenia and the role of antipsychotic medication type

Cited by 38 publications

References 36 publications

Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Schizophrenia patients using atypical medication perform better in visual tasks than patients using typical medication

Spatial contrast sensitivity: effects of reliability, test–retest repeatability and sample size using the Metropsis software

The Use of Electroretinography and Optical Coherence Tomography in Patients with Schizophrenia

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