Color and genomic ancestry in Brazilians

Parra, Flávia C.; Amado, R; Lambertucci, José Roberto; Rocha, Jorge; Antunes, Carlos; Pena, Sérgio D. J.

doi:10.1073/pnas.0126614100

Cited by 836 publications

(731 citation statements)

References 20 publications

(18 reference statements)

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“…Compri et al [22] demonstrated prevalence in male Afro-descendants as 10%. It might have happened due to the ethnic classification in these studies, and perhaps because that the skin color is not a true indicator of ethnic origin in Brazil [23] .…”

Section: Discussionmentioning

confidence: 87%

Glucose-6-phosphate-dehydrogenase deficiency and its correlation with other risk factors in jaundiced newborns in Southern Brazil

Carvalho

Castro

Santin

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 87%

Glucose-6-phosphate-dehydrogenase deficiency and its correlation with other risk factors in jaundiced newborns in Southern Brazil

Carvalho

Castro

Santin

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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“…It might have been exposed to factors such as population stratification, but previous investigations have shown an absence of structure in this southern Brazilian population. 18,19 Moreover, despite the small sample size, our investigation has statistical power (77.1%) to detect a pharmacogenetic influence of differential responses to simvastatin treatment as a function of SCAP genotype, emphasizing the relevance of this high-frequency SNP of the SCAP gene.…”

Section: Srebf-scap Pathway Snps and Variable Response To Simvastatinmentioning

confidence: 87%

Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes

et al. 2005

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We investigated the effect of single-nucleotide polymorphisms in sterol regulatory element-binding factors-1a and -2 (SREBF-1a and SREBF-2) and SREBF cleavage-activating protein (SCAP) genes on lipid-lowering response to simvastatin. In all, 146 hypercholesterolemic patients of European descent were prospectively treated with simvastatin 20 mg/day for over 6 months. Of these 99 subjects completed the 6-month follow-up. Plasma lipids and lipoproteins were measured before and throughout the study. The mean percentage decrease in plasma total cholesterol (TC) was greater in subject carriers of SCAP 2386G allele compared with those homozygous for 2386A allele (À29.6713.4 vs À22.1713.8%, P ¼ 0.007). About 61% of the 2386G carriers were above-average responders for TC levels (DTC À27.8%), whereas only 29% of 2386A homozygous reached this reduction (P ¼ 0.009). Our data suggest that the SCAP 2386A4G gene polymorphism was a significant predictor of TC and triglyceride responses to simvastatin treatment.

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“…All the included individuals were from the same socioeconomic level with similar cultural habits, and all were native of Minas Gerais state with the same ethnic background, approximately 33% of Portuguese, 33% of Amerindian and 33% of African ancestry, homogeneously present in each subject. 21 In the group of carcinoma patients, H. pylori status was based on culture, preformed urease test, carbolfuchsin-stained smear or histologic section, serology, polymerase chain reaction (PCR) for ureA and urea breath test. The patients were considered to be H. pylori-positive if either the culture or 2 of the other tests were positive.…”

Section: Methodsmentioning

confidence: 99%

“…There is not a clear segregation in Brazil, by contrast with other mixed populations. This explains why the Brazilian population has a discrete homogeneous genetic background, 21 regardless of the skin color or other racial features. Thus, the importance cannot be overemphasized of investigating genetic factors in these admixed individuals, since one could not use racial features to preview a sickness pattern in a subject with Brazilian background.…”

mentioning

confidence: 99%

IL1RN polymorphic gene and cagA‐positive status independently increase the risk of noncardia gastric carcinoma

Rocha

Guerra

Rocha

et al. 2005

Intl Journal of Cancer

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Helicobacter pylori cagA-positive strains and host cytokine proinflammatory polymorphisms have been associated with gastric carcinoma. However, the individual role of each factor has not been evaluated yet. Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-a (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in a non-Caucasian population by analyzing the data in logistic regression models. We evaluated 166 patients with noncardia gastric carcinoma and 541 blood donors. Among them, 702 were successfully genotyped for all cytokine studied: 166 with gastric carcinoma and 536 controls. The carcinoma patients were considered to be H. pylori-positive if culture alone or 2 among preformed urease test, stained smear or histologic section, serology, polymerase chain reaction (PCR) for ureA and urea breath test were positive. In blood donors, H. pylori status was based on enzyme-linked immunosorbent assay. The cagA status was determined by PCR or serology. IL1B-511/-31, IL1RN (interleukin-1 receptor antagonist) and TNFA-307 polymorphisms were genotyped by PCR, PCR with restriction fragment length polymorphism, or PCR with confronting 2-pair primers. We found that the IL1RN2 polymorphic allele (OR 5 1.93) was associated with noncardia gastric carcinoma, even after inclusion of age, gender and cagA status in the logistic models. However, the cagA-positive status was the strongest independent factor associated with gastric carcinoma (OR 5 11.89). The other polymorphisms were not significantly associated with the disease when they were evaluated in logistic models. This study provides evidence supporting the independent associations of cagA-positive H. pylori status and IL1RN polymorphisms with noncardia gastric carcinoma. ' 2005 Wiley-Liss, Inc.

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Color and genomic ancestry in Brazilians

Cited by 836 publications

References 20 publications

Glucose-6-phosphate-dehydrogenase deficiency and its correlation with other risk factors in jaundiced newborns in Southern Brazil

Glucose-6-phosphate-dehydrogenase deficiency and its correlation with other risk factors in jaundiced newborns in Southern Brazil

Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes

IL1RN polymorphic gene and cagA‐positive status independently increase the risk of noncardia gastric carcinoma

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