Colon cancer of Peutz-Jeghers syndrome with gallolyticus endocarditis

Miyahara, Kiyoshi; Tobe, Shunichi; Shizuku, Tatsunori; Inamoto, Rin; Katayama, Ikuo

doi:10.1007/s12328-019-01080-9

Cited by 3 publications

(3 citation statements)

References 20 publications

(29 reference statements)

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“…Patients with PJS syndrome have a higher risk of developing gastrointestinal, breast, pancreatic, cervical, and ovarian cancers. For female patients, the risk of developing gynecological cancers is approximately 15 times higher than that of normal women ( 9 ). Recently, germline mutations in STK11/LKB1 were identified in more than 30% of patients with PJS ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Peutz-Jeghers syndrome with gastric-type mucinous endocervical adenocarcinoma and sex-cord tumor with annular tubules: A case report

Qi²,

Zhang³

et al. 2023

Front. Med.

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Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant genetic disorder characterized by mucocutaneous pigmentation and multiple hamartomatous polyps in the gastrointestinal tracts. About 11% of female PJS patients are diagnosed with Gastric-type endocervical adenocarcinoma (G-EAC) and about one third have a sex-cord tumor with annular tubules (SCTATs). Gastric-type endocervical adenocarcinoma is a special subtype of cervical adenocarcinoma which accounts for only 1–3%. Here we report a rare case of a 31-year-old woman affected with G-EAC and SCTAT accompanied by PJS. After surgery, we followed up for 5 years without recurrence.

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Section: Discussionmentioning

confidence: 99%

Peutz-Jeghers syndrome with gastric-type mucinous endocervical adenocarcinoma and sex-cord tumor with annular tubules: A case report

Qi²,

Zhang³

et al. 2023

Front. Med.

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“…As per findings, out of 419, 297 patients were documented to have STK11 mutations and 23% of them developed cancer. From these studies, it was proposed that breast cancer and luminal GI cancers is most common cancer associated with it, followed by pancreatic cancer [46][47][48] . Hearle and team reported the higher risk of cancer after the age of 50.…”

Section: Associated Cancer Risk With Pjsmentioning

confidence: 99%

Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome

Altamish

Dahiya

Singh

et al. 2020

Crit Rev Eukaryot Gene Expr

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Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps, and characteristic mucocutaneous freckling. PJS, an autosomal prevailing disease due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumour suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms which develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumour growth in the cancers of PJS patients. This article has focused on role of LKB1 or STK11 gene expression in PJS and related cancers.

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“…However, only a few studies have evaluated the performance of MALDI-TOF MS in the accurate identification of the species and subspecies of SBSEC [ 11 – 13 ]. Additionally, SBSEC infections are limited and have not been investigated fully [ 14 , 15 ]. Therefore, this study aimed to identify the clinical characteristics of SBSEC bacteremia in Japanese patients and evaluate the accuracy of identification of the MALDI-TOF MS system (MALDI Biotyper) and phenotypic identification system (VITEK2), using sodA sequencing as the reference standard.…”

Section: Introductionmentioning

confidence: 99%

Laboratory identification and clinical characteristics of Streptococcus bovis/Streptococcus equinus complex bacteremia: a retrospective, multicenter study in Hiroshima, Japan

et al. 2021

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Background Bacteremia due to the Streptococcus bovis/Streptococcus equinus complex (SBSEC) is associated with specific diseases, such as colorectal cancer and infective endocarditis. This study aimed to evaluate the clinical characteristics of SBSEC bacteremia and the accuracy of identification of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and phenotypic identification systems for SBSEC isolates. Methods We analyzed patients with SBSEC bacteremia retrospectively between 2012 and 2019 at three hospitals in Japan. We re-identified each SBSEC isolate using sequencing superoxide dismutase (sodA) analysis, MALDI-TOF MS using the MALDI Biotyper, and phenotypic identification using the VITEK2. Results During the study period, 39 patients with SBSEC bacteremia were identified. S. gallolyticus subsp. pasteurianus (SGSP, n = 29), S. gallolyticus subsp. gallolyticus (SGSG, n = 5), S. lutetiensis (SL, n = 4), and S. infantarius subsp. infantarius (n = 1) were identified using sodA sequencing analysis. Primary bacteremia (36%) was the most common cause of bacteremia, followed by infective endocarditis (26%) and biliary tract infections (23%). Colorectal cancer was associated significantly with SGSG bacteremia, while the sources of bacteremia were similar in each SBSEC subspecies. The MALDI Biotyper was significantly more accurate in identifying the SBSEC isolates at the subspecies level compared to the VITEK2 (92% vs. 67%, P = 0.010). In contrast, there were no significant differences in the rates of correct identification of the SBSEC isolates at the species level between the MALDI Biotyper and the VITEK2 (100% vs. 87%, P = 0.055). Conclusions Bacteremia with SGSG was associated with colorectal cancer, and the sources of bacteremia were similar in each SBSEC subspecies. The MALDI-TOF MS was significantly more accurate in identifying SBSEC isolates at the subspecies level than the phenotypic identification systems. The accurate identification of SBSEC isolates using the MALDI-TOF MS and phenotypic identification systems was sufficient at the species level, but it was insufficient at the subspecies level. Therefore, it may be reasonable for clinicians to perform echocardiographies and colonoscopies in all patients with SBSEC bacteremia.

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Colon cancer of Peutz-Jeghers syndrome with gallolyticus endocarditis

Cited by 3 publications

References 20 publications

Peutz-Jeghers syndrome with gastric-type mucinous endocervical adenocarcinoma and sex-cord tumor with annular tubules: A case report

Peutz-Jeghers syndrome with gastric-type mucinous endocervical adenocarcinoma and sex-cord tumor with annular tubules: A case report

Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome

Laboratory identification and clinical characteristics of Streptococcus bovis/Streptococcus equinus complex bacteremia: a retrospective, multicenter study in Hiroshima, Japan

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