Colloids versus crystalloids for fluid resuscitation in critically ill patients

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“…Based on the lack of evidence documenting improved outcome, potential deleterious effects, and substantial economic strain on the health care system, we agree with the recent review by Alderson and colleagues [19]. They concluded "it is hard to see how their (colloids) continued use in these patient types (critically ill) can be justified outside the context of randomized controlled trials".…”

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“…Based on the lack of evidence documenting improved outcome, potential deleterious effects, and substantial economic strain on the health care system, we agree with the recent review by Alderson and colleagues [19]. They concluded "it is hard to see how their (colloids) continued use in these patient types (critically ill) can be justified outside the context of randomized controlled trials".…”

Albumin Use in Neurosurgical Critical Care

“…8,9 In 2000, the Cochrane Database Systematic Reviews presented studies of albumin in critically ill patients for a variety of indications. 10,11 No advantage was found for albumin over other colloids or crystalloids in these analyses. In response to the 1998 Cochrane Review, the Food and Drug Administration (FDA) cautioned the entire medical community to consider carefully the meta-analysis findings and adopt prescribing patterns that adhere to accepted guidelines.…”

Stimulation of Wnt/β-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock

“…This resuscitation method was chosen because such fluids are readily available in clinical settings. However neither crystalloids nor colloids alone had any major benefit in trauma outcome 42–44 . Our studies suggest that Wnt agonist delivered in low volume crystalloid preserved the Wnt/β-catenin signaling pathway during resuscitation following hemorrhagic shock and was protective from systemic inflammation as well as the injury to the lungs.…”

Untitled

“…Based on the lack of evidence documenting improved outcome, potential deleterious effects, and substantial economic strain on the health care system, we agree with the recent review by Alderson and colleagues [19]. They concluded "it is hard to see how their (colloids) continued use in these patient types (critically ill) can be justified outside the context of randomized controlled trials".…”

Albumin Use in Neurosurgical Critical Care

“…8,9 In 2000, the Cochrane Database Systematic Reviews presented studies of albumin in critically ill patients for a variety of indications. 10,11 No advantage was found for albumin over other colloids or crystalloids in these analyses. In response to the 1998 Cochrane Review, the Food and Drug Administration (FDA) cautioned the entire medical community to consider carefully the meta-analysis findings and adopt prescribing patterns that adhere to accepted guidelines.…”

Stimulation of Wnt/β-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock

“…This resuscitation method was chosen because such fluids are readily available in clinical settings. However neither crystalloids nor colloids alone had any major benefit in trauma outcome 42–44 . Our studies suggest that Wnt agonist delivered in low volume crystalloid preserved the Wnt/β-catenin signaling pathway during resuscitation following hemorrhagic shock and was protective from systemic inflammation as well as the injury to the lungs.…”

Untitled

“…Based on the lack of evidence documenting improved outcome, potential deleterious effects, and substantial economic strain on the health care system, we agree with the recent review by Alderson and colleagues [19]. They concluded "it is hard to see how their (colloids) continued use in these patient types (critically ill) can be justified outside the context of randomized controlled trials".…”

Albumin Use in Neurosurgical Critical Care

“…8,9 In 2000, the Cochrane Database Systematic Reviews presented studies of albumin in critically ill patients for a variety of indications. 10,11 No advantage was found for albumin over other colloids or crystalloids in these analyses. In response to the 1998 Cochrane Review, the Food and Drug Administration (FDA) cautioned the entire medical community to consider carefully the meta-analysis findings and adopt prescribing patterns that adhere to accepted guidelines.…”

Stimulation of Wnt/β-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock

“…This resuscitation method was chosen because such fluids are readily available in clinical settings. However neither crystalloids nor colloids alone had any major benefit in trauma outcome 42–44 . Our studies suggest that Wnt agonist delivered in low volume crystalloid preserved the Wnt/β-catenin signaling pathway during resuscitation following hemorrhagic shock and was protective from systemic inflammation as well as the injury to the lungs.…”