1943
Colloid Pseudomilium
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1944
2011
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Cited by 18 publications
(2 citation statements)
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“…In spite of numerous investigations, the precise etiology remains unknown, although prolonged sun exposure is undoubtedly involved in its pathogenesis. Sun exposure may cause direct structural damage to elastin, affect the synthesis of elastin by fibroblasts, or trigger degradative enzymes such as elastase and other proteases, leading to the destruction of elastic fibers 7–9 . The clinical differential diagnosis may include calcinosis cutis, milia, multiple syringoma, and amyloidosis.…”
Section: Discussionmentioning
confidence: 99%
“…In spite of numerous investigations, the precise etiology remains unknown, although prolonged sun exposure is undoubtedly involved in its pathogenesis. Sun exposure may cause direct structural damage to elastin, affect the synthesis of elastin by fibroblasts, or trigger degradative enzymes such as elastase and other proteases, leading to the destruction of elastic fibers 7–9 . The clinical differential diagnosis may include calcinosis cutis, milia, multiple syringoma, and amyloidosis.…”
Section: Discussionmentioning
confidence: 99%
“…In 1925, Gans 5 postulated that CM was caused by the breakdown of collagen material. In 1943, Arnold 6 postulated that breakdown of elastin might also be involved. Prolonged, unprotected sun exposure is clearly involved in the pathogenesis of CM, but the mechanism through which this occurs is not understood.…”
Section: Commentmentioning
confidence: 99%
