Colloid Milium: A Histopathologic Mimicker of Nodular Amyloidosis

Desai, Anupam M.; Pielop, Josie; Smith-Zagone, Megan J.; Hsu, Sylvia

doi:10.1001/archderm.142.6.784

Cited by 13 publications

(8 citation statements)

References 4 publications

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“…The pathogenesis is unknown, although it is assumed to be due to degeneration of cutaneous elastic fibers as a result of excess sun exposure. There is some evidence to suggest a genetic predisposition, and some cases have been felt to be due to exposure to petroleum products or hydroquinone . Clinically, CM is characterized by multiple yellow or flesh colored, dome‐shaped papules.…”

Section: Discussionmentioning

confidence: 99%

Nodular colloid milium mimicking keloid

Azimi

Zargari²,

Rudolph

2017

J of Cosmetic Dermatology

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Colloid milium is a rare cutaneous deposit disease that usually presents clinically by the development of yellowish translucent or flesh-colored papules or plaques on sun-exposed skin. Histologically, it is characterized by the presence of colloid in the dermal papillae. In this case report, we present a 52-year-old man who presented with a nodule on his upper lip that mistakenly was diagnosed and treated as keloid.

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Section: Discussionmentioning

confidence: 99%

Nodular colloid milium mimicking keloid

Azimi

Zargari²,

Rudolph

2017

J of Cosmetic Dermatology

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“…However, some studies have reported cases of colloid milium appearing on areas of skin that are not exposed to ultraviolet light. 1,2 Diagnosis is based on light microscopy study of a skin sample, which shows fissured eosinophilic colloid masses in the papillary dermis, with solar elastosis and a Grenz zone of elastin fibres that separates the lesion from the rest of the epidermis. 4 Some fibroblasts can be observed in cleft formations, together with some lymphocytes, mast cells and enlarged veins, with preservation of adnexa.…”

Section: Discussionmentioning

confidence: 99%

Adult colloid milium. An underdiagnosed and difficult to treat entity

Zamora

Simon

Sánchez

et al. 2016

Revista Médica del Hospital General de México

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Millium colloid is a rare cutaneous deposition disorder of unknown aetiology on lightexposed skin. It presents as flesh-coloured or yellow papules. A skin biopsy and light microscopy study is required for diagnosis, with findings of fissured eosinophilic colloid masses in the papillary dermis, with solar elastosis that is separated from the epidermis by a Grenz zone containing normal collagen. There is no single effective treatment. We present a case report of a 42-yearold man with papular lesions on the dorsum of both hands and a history of prolonged sun exposure. © 2015 Sociedad Médica del Hospital General de México. Published by Masson Doyma México S.A. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). PALABRAS CLAVE Millium coloide; Fotoexposicion Milium Coloide del Adulto. Una entidad subdiagnosticada y de difícil tratamientoResumen El millium coloide es una enfermedad de depósito, presente en áreas fotoexpuesta y de etiología desconocida. Clínicamente se identifica como lesiones de aspecto papular de color rosa o amarillo. Para su diagnóstico es necesario realizar una biopsia de piel para microscopía de luz, donde se observan masas eosinofílicas fisuradas en la dermis papilar en presencia de elastosis solar y una zona de Grenz de fibras elásticas que separa la lesión del resto de la epidermis. Hasta el momento no existe un tratamiento de elección. Se presenta el reporte de un caso de un paciente masculino de 42 años con lesiones de aspecto papular en dorso de manos, con el antecedente de exposición crónica a la luz solar.

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“…However, the most important clinical and histological differential diagnosis is primary cutaneous (nodular) or secondary cutaneous amyloidosis [7]. However, the latter is characterized by strong Congo red staining, and shows characteristic red-green dichroism under polarized light.…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, said colloid degeneration of elastic fibers might be referred to as colloid elastosis. While clinical and histological findings frequently point to the correct diagnosis, differential diagnostic considerations have to include the following disorders: However, the most important clinical and histological differential diagnosis is primary cutaneous (nodular) or secondary cutaneous amyloidosis [7]. However, the latter is characterized by strong Congo red staining, and shows characteristic red-green dichroism under polarized light.…”

Section: Discussionmentioning

confidence: 99%