Colloid Degeneration of the Skin

Labadie, John H.

doi:10.1001/archderm.1927.02380020028004

Cited by 18 publications

(4 citation statements)

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“…The third form, known as ‘nodular colloid degeneration’, was first described by Labadie in 1927 10 and later by other authors 11,12 . It consists of isolated or multiple plaques and nodules 0·5–5·0 cm in diameter, 11 which are located predominantly on the face but can also develop on the trunk and extremities.…”

Section: Discussionmentioning

confidence: 99%

Papuloverrucous colloid milium: an occupational variant

Muscardin

Bellocci

Băluş

2000

British Journal of Dermatology

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We report a case of adult colloid milium in a 47-year-old mechanic with a long history of professional contact with lubricating oils and of sun exposure. In addition to the typical translucent papules seen on the forehead, there were warty papules on the backs of both hands with unusual histological and ultrastructural features: marked hyperplasia of the epidermis with orthokeratotic hyperkeratosis and papillary deposits of colloid material that were contiguous with the basal layer of the epidermis. The hand lesions caused by occupational exposure to mineral oils and solar radiation represent an occupational variant of adult colloid milium.

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Section: Discussionmentioning

confidence: 99%

Papuloverrucous colloid milium: an occupational variant

Muscardin

Bellocci

Băluş

2000

British Journal of Dermatology

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“…The disseminated colloid, on the other hand, forms patches or nodules, 0.5 to 5 cm in diameter, pink, yellow or brown in color and having a slightly lumpy surface. It is more or less telangiectatic, single or multiple patches predominantly found on the face, but sometimes on the trunk (Labadie 1972, Reuter & Becker 1942, Bienvenu & Lever 1958, SuUivan & ElUs 1961.…”

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confidence: 99%

Paracolloid of the Skin

et al. 1979

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A 51-year-old Caucasian man presented with a yellowish lesion containing multiple protuberances over his right cheek. Light and electron microscopic examination revealed an anhistic substance lacking definite characteristics of either amyloid or collid milium. The term paracolloid degeneration of the skin is introduced to designate this substance which is believed to derive from collagen. A review of the literature showed similar cases previously published under the names of nodular amyloidosis or disseminated colloid.

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“…Colloid milium is currently classified into three different subtypes; (a) adult type (1-7), which occurs on sun-exposed areas such as face, ears, neck and dorsum of hands as small or confluent semi-translucent papules, (b) juvenile form (8), which has been attributed to keratinocyte degeneration and (c) pigmented colloid milium (9) associated with exogenous ochronisis due to hydroquinone bleaching cream among South African blacks. A vague entity called nodular colloid degeneration (10)(11)(12) or paracolloid of the skin (13) may represent a tumefactive nodular amyloidosis which is now characterized as an accumulation of light chain of immunoglobulins. (14,15).…”

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Juvenile colloid milium

et al. 1989

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A 7-year-old Italian girl with juvenile colloid milium was studied with histological, immunohistochemical, and electron microscopic methods. This patient had a well-documented history of severe sunburn and developed the lesions on the face shortly afterward. Numerous apoptotic keratinocytes were observed in the lower epidermis. These cells began their degeneration with filamentous whorl formation (or filamentous degeneration) of tonofilaments. In the papillary dermis the colloid substance was resolved by the electron microscopy into either wavy, thin filaments derived from the epidermal keratinocytes or typical amyloid filaments. Many desmosomes and gap junctions were found in the colloid substance. Polyclonal antikeratin antibody (DAKO) was positive in the colloid substance, particularly in the parts close to the epidermis. These findings suggested that juvenile colloid milium is different from adult colloid milium despite clinical similarities and that the former belongs to the group of actinic amyloid K, i.e. amyloidoses due to actinic degeneration of keratinocyte and its keratin.

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Colloid Degeneration of the Skin

Cited by 18 publications

References 1 publication

Papuloverrucous colloid milium: an occupational variant

Papuloverrucous colloid milium: an occupational variant

Paracolloid of the Skin

Juvenile colloid milium

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