Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Abstract

This report presents the case of a 62-year-old man with a collision tumor of primary malignant lymphoma and adenocarcinoma in the cecum. All regional mesenteric lymph nodes that were removed surgically were found to be occupied by lymphoma cells and no lymph nodes contained any cancer cells, although the primary carcinomas did exhibit lymphatic invasion. Malignant lymphoma was also seen in the duodenum. Systemic chemotherapy was administered for the malignant lymphoma, and a complete response was thus obtained. However, just after chemotherapy multiple liver metastases of adenocarcinoma emerged, and chemotherapy against adenocarcinoma was therefore continued. The occurrence of synchronous lymphoma and adenocarcinoma of the colorectum is rare. Furthermore, collisions of these different entities are also extremely unusual; so far only five such case reports have been published. The accurate clinical determination of the dominant tumor and a close follow-up is required for proper treatment in these cases.

Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis in the colon: a case report and literature review

“…Previous reports have been limited because of the rarity of such collision tumors, and most reports did not describe the course of the disease after diagnosis. Sasaki et al [6] reported that a patient received six courses of combined chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone regimen with rituximab) against malignant lymphoma, which yielded a complete response. In our case, the patient underwent six courses of chemotherapy with mFOLFOX6 followed by capecitabine to treat sigmoid colon adenocarcinoma with lung metastasis.…”

“…Additionally, colon lymphomas represent 5.6% to 20% of all gastrointestinal lymphomas [10]. Furthermore, lymphoma synchronously accompanied by adenocarcinoma of the colon is extremely rare [6]. …”

Colorectal Manifestation of Follicular Lymphoma

“…Our literature search identified nine case reports in which detailed morphological characteristics were described and endoscopic images were presented (Table 2) (2, 18-25). Among the reported cases, Sasaki et al described a patient with a collision tumor of follicular lymphoma and adenocarcinoma in the cecum (22). In this patient, a large tumor (15 cm) was seen by colonoscopy, but the pathological examinations of the resected specimen revealed the adenocarcinoma component to be predominant.…”

Collision tumor of colonic adenocarcinoma and EBV-driven large B-cell lymphoma: A case report and review of literature

“…To our knowledge, there are fifteen cases of this type of collision to date, including this report (Table 1) [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. There is a male and elderly predominance at an average age The majority of collisions arise in the cecum or rectum, with eight arising from the right colon, one from the transverse colon, and six from the left colon.…”