Collection of two units of leukoreduced RBCs from a single donation with a portable multiple‐component collection system

Abstract

The quality of leukoreduced RBCs collected with this portable automated component collection system met or exceeded FDA requirements. This automated system is safe and effective for collection and processing of 2 units of RBCs suitable for transfusion.

In vitro quality of red blood cells (RBCs) collected by multicomponent apheresis compared to manually collected RBCs during 49 days of storage

“…Compared to MRBCs, ARBCs exhibited considerably lower variability in volume and absolute RBC mass but contained significantly more plasma (up to 37 mL/ unit) and citrate (up to 11 mL/unit), which was in contrast to the work of Knutson and associates 15 who reported less citrate with ARBCs. Our data on in vitro properties and unit processing characteristics comply favorably with previous reports on Alyx, 6,16,17 Amicus, 4 Trima Accel, 18 and MCS+ 1,3,19 whereby most of these studies lacked the MRBC-comparison group. Some comparative investigations 1,3 reported higher values for hemolysis (0.61%), free Hb (120-372 mg/dL), and K + (54.6-63.0 mmol/L) with MRBCs than observed in our study (0.23%; 93 mg/dL; 39 mmol/L), but combined data from different centers with different methods 1 or received MRBCs from a foreign center.…”

“…New technical developments allow for the collection of RBCs by apheresis (ARBCs), which is a fundamental evolution in transfusion technology and probably offers the potential for improved product consistency and quality. [1][2][3][4][5][6] From the donor's point of view, automated RBC collection is less often associated with vasovagal reactions, most likely due to better fluid balance. 7,8 Storage of RBCs suspended in a plasma-free additive solution such as saline-adenine-glucose-mannitol (SAGM) is currently limited to 42 days during which the 24-hour posttransfusion recovery decreases gradually as the so-called "storage" and "collection injuries" increase.…”

Comparison of in vitro Characteristics of Leukodepleted Red Blood Cells (RBCs) Derived from Apheresis: Impact of Filter Performance

“…Hence, the lower RBC loss noted with double-unit filtration could be considered as an advantage over single-unit filtration during 2-RBCA. The RBC loss of some TA and MCS+ units exceeded 15% which is the upper FDA (US Food and Drug Administration) limit [3,12]. In addition, a mean of 153 ml of absolute RBC mass, which is the acceptable mean RBC content for leukoreduced apheresis RBCs established by the AABB standards [13], was not reached by TA and MCS+ units.…”

“…Despite variations in donor hematocrit, apheresis-derived units are better standardized with respect to volume and RBC mass [8]. As apheresis donors are often repeat donors who have a lower prevalence of transmissible diseases [3], the transfusion of apheresis RBCs could reduce the risk of infection, particularly if 2 packed RBCs from the same donor are available to a single recipient. Additionally, automated RBC collection providing complete blood products may reduce costs in transfusion medicine [5].…”

A Prospective Crossover Trial Comparing Performance and in vitro Platelet Quality of Three New Apheresis Devices with Current Equipment

“…Concurrently, the recruitment and retention of voluntary and eligible blood donors is becoming increasingly difficult due to aging of the population and more stringent exclusion criteria for blood donation. High-dose PLT apheresis enabling the collection of multiple units in a single donation may have the potential to counteract this problem and to reduce both, costs and risks inherent with allogenic transfusion [2][3][4][5]. As a result, the industry has introduced new apheresis systems or modified existing equipment for better productivity and donor safety.…”