Collagenous Gastritis

Lagorce-Pagès, Christine; Fabiani, Bettina; Bouvier, Raymonde; Scoazec, Jean‐Yves; Durand, L; Fléjou, Jean‐François

doi:10.1097/00000478-200109000-00008

Cited by 96 publications

(48 citation statements)

References 20 publications

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“…28,37,38 These findings suggest that collagen deposition could be a generalized disease affecting the entire gastrointestinal tract. Thus, active investigation of associated disorders may be advisable.…”

Section: Discussionmentioning

confidence: 90%

Gluten-Free Diet and Steroid Treatment Are Effective Therapy for Most Patients With Collagenous Sprue

Rubio–Tapia

Talley

Gurudu

et al. 2010

Clinical Gastroenterology and Hepatology

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BACKGROUND & AIMS Collagenous sprue (CS) is characterized by the presence of a distinctive band of subepithelial collagen deposition in the small bowel. We evaluated the clinical characteristics, treatments, and outcomes of patients with CS. METHODS Thirty patients with CS were identified at the 3 Mayo Clinic sites between 1993 and 2009. Clinical data from medical records were reviewed. RESULTS The study cohort was 70% female (age range, 53–91 years). Most patients had severe diarrhea and weight loss. Hospitalization to treat dehydration was necessary in 16 (53%) patients. Associated immune-mediated diseases were noted in 70% of the patients; celiac disease was the most frequent. Other associated diseases were microscopic colitis, hypothyroidism, and autoimmune enteropathy. The median thickness of the layer of subepithelial collagen deposition in the small bowel was 29 μm (20 –56.5 μm). Subepithelial collagen deposition in the colon or stomach was noted in 8 patients. A clinical response was observed in 24 (80%) patients after treatment with a combination of a gluten-free diet and immunosuppressive drugs. Histologic improvement was confirmed in 9 patients, with complete remission in 5. Two patients died (1 of complications of CS and 1 of another illness). CONCLUSIONS Most patients with CS are treated effectively with a combination of gluten-free diet and steroids. CS is often associated with collagen deposition or chronic inflammation in other segments of the gastrointestinal tract as well as other immune-mediated disorders.

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Section: Discussionmentioning

confidence: 90%

Gluten-Free Diet and Steroid Treatment Are Effective Therapy for Most Patients With Collagenous Sprue

Rubio–Tapia

Talley

Gurudu

et al. 2010

Clinical Gastroenterology and Hepatology

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“…Collagenous infiltrative inflammation of the GI mucosa tract was first described in small intestine as collagenous sprue, then in large intestine as collagenous colitis and recently in stomach as collagenous gastritis [7]. Association between collagenous infiltrative disorder of the GI tract and CVID/hypogammaglobulinemia is not recognized.…”

Section: Discussionmentioning

confidence: 99%

Association between common variable immunodeficiency and collagenous infiltrative disorders of the gastrointestinal tract: A series of four patients

Mandaliya

Burkart

DiMarino

et al. 2016

Indian J Gastroenterol

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Hypogammaglobulinemia/common variable immunodeficiency (CVID) may lead to disruption of the gut mucosal immune barrier. Collagenous infiltrative disorders of the intestinal tract (colitis, gastritis, sprue) constitute a relatively new spectrum of gastrointestinal disorders. Our aims were (1) to determine the association between immunoglobulin deficiency state like CVID and collagenous infiltrative disorders of the gut and (2) to study the clinic-pathologic characteristics and treatment outcomes in these patients. A retrospective search was conducted to identify cases with concurrence of these two conditions at an academic center from 2007 to 2013. Four such patients were identified from our database: three with collagenous colitis and one with collagenous gastritis. All patients with collagenous colitis had normal colonic mucosa while the patient with collagenous gastritis had nodular gastric mucosa. Only one patient out of four had decreased plasma cells in the submucosa as expected in low immunoglobulin states. All patients had improvement in their symptoms on immunoglobulin therapy with considerable remission on budesonide. Literature search revealed reporting of four similar patients. In conclusion, (1) the association between collagenous infiltrative disorders of the gut and CVID and its prompt response to immunoglobulins with effective maintenance with budesonide are novel findings. Our study also shows that the presence of plasma cells should not rule out the possibility of CVID. (2) In patients with chronic diarrhea, hypogammaglobulinemia and collagenous colitis/sprue should be considered for the available effective treatments such as immunoglobulins and budesonide.

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“…Those activated immune cells produce cytokines and growth factors that stimulate the production of the extracellular matrix leading to collagen deposition. Collagenous gastritis usually presents with anemia from upper gastrointestinal bleeding and epigastric pain [6]. On endoscopy, the involved mucosa appears thickened and nodular with a diffuse cobblestone appearance.…”

Section: Discussionmentioning

confidence: 99%

“…There are no established treatment protocols for collagenous gastroenteritides, including collagenous gastritis, and resolution of the abnormalities either endoscopic or histologic has not been documented. Various therapies have been tried for collagenous gastritis including corticosteroids, ranitidine, omeprazole, misoprostol, sucralfate, aminosalicylates, sulfasalazine, cholysteramine and a hypoallergenic diet with marginal results [2,6,7,10]. …”

Section: Discussionmentioning

confidence: 99%

An unusual case of collagenous gastritis in a middle- aged woman with systemic lupus erythromatosis: a case report

et al. 2014

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IntroductionCollagenous gastritis is a rare histopathologic disease. It is characterized by marked subepithelial collagen deposition with associated inflammatory infiltrate. It is considered an uncommon disease among the general population. Collagenous gastritis without colonic involvement is an extremely rare disease. It is not known to be associated with systemic lupus erythromatosis. This is the first report of this type of association.Case presentationWe present a 47-year-old woman from southeast Asia with dyspepsia and mild anemia. Her past medical history was significant for systemic lupus erythromatosis, autoimmune hemolytic anemia as well as hypothyroidism. Her gastroscopy and colonoscopy results were normal from an endoscopic point of view. However, the histopathology showed collagenous gastritis.ConclusionsTo the best of our knowledge, this is the first case reported of a patient with systemic lupus erythromatosis associated with collagenous gastritis. Further studies are needed to evaluate the association between both diseases from a pathophysiological and immunological perspective.

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Collagenous Gastritis

Cited by 96 publications

References 20 publications

Gluten-Free Diet and Steroid Treatment Are Effective Therapy for Most Patients With Collagenous Sprue

Gluten-Free Diet and Steroid Treatment Are Effective Therapy for Most Patients With Collagenous Sprue

Association between common variable immunodeficiency and collagenous infiltrative disorders of the gastrointestinal tract: A series of four patients

An unusual case of collagenous gastritis in a middle- aged woman with systemic lupus erythromatosis: a case report

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