Collagenous colitis and coeliac disease.

Breen, E. G.; Farren, Conor K.; Connolly, C. E.; McCarthy, Colm

doi:10.1136/gut.28.3.364

Cited by 36 publications

(14 citation statements)

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“…A close association between lymphocytic and collagenous colitis and celiac sprue has been seen in some patients (25)(26)(27)(28)(29)(30). It is now recognized that the intraepithelial lymphocytes may have a role in the putative immunopathology of celiac sprue (31).…”

Section: Discussionmentioning

confidence: 98%

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Padmanabhan

Callas

et al. 2003

Modern Pathology

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Biopsy specimens from the terminal ileum of 32 patients with the histopathological diagnosis of lymphocytic colitis or collagenous colitis and 11 control individuals were evaluated for the presence or absence of ileal mucosal abnormalities and for the number of intraepithelial lymphocytes, assessed by immunohistochemical stains for the pan T-cell marker, CD3. We found that the mean CD3 counts in patients with lymphocytic/collagenous colitis were significantly higher than those in the control group. Seven of 14 patients with collagenous colitis and 14 of 18 patients with lymphocytic colitis revealed an increase in intraepithelial T lymphocytes when compared with the control group (P ‫؍‬ .001). Other notable changes included ileal villous atrophy in one case of lymphocytic colitis and in three cases of collagenous colitis and epithelial damage with thickened subepithelial collagen in two cases of collagenous colitis.

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Section: Discussionmentioning

confidence: 98%

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Padmanabhan

Callas

et al. 2003

Modern Pathology

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“…Some patients have also been shown to respond to corticosteroids or sulfasalazine, although this response is not uniform [3,4,19]. Finally, several patients with celiac disease have been identified with CC, and celiac disease is suspected to have an autoimmune component [8,11,25]. However, no immunoglobulin components or other immune complexes have been identified in these patients [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…The small bowel is not actively involved in this disease except for one case where a slight collagen infiltrate was identified [11]. It has been noted that CC is occasionally seen in patients with celiac disease, and the radiographic changes of sprue may be evident in these patients [8,25]. The clinical course of these patients is variable and adds to the confusion surrounding the classification of this disease [2,3,9].…”

Section: Discussionmentioning

confidence: 99%

Nonspecific radiographic abnormalities in collagenous colitis

Feczko

Mezwa

1991

Gastrointest Radiol

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Collagenous colitis (CC) is characterized clinically by a chronic, watery diarrhea. Pathologically, there is a chronic lymphocytic infiltrate with abnormal thickening of the subepithelial collagen layer. This disease occurs predominantly in females, and is more frequent in the elderly. Previous clinical studies suggest that radiographic examination of the colon is of no value in this condition. We reviewed five cases of CC all of whom had colon examination within 2 weeks of the biopsy. Two of our patients showed evidence of mucosal granularity and irregularity of the rectosigmoid on double-contrast barium enema (DCBE). One patient had nodularity of the rectal wall on single-contrast colon examination. Two patients had no inflammatory changes evident on colon examination. These radiographic changes are nonspecific and may be seen in other forms of colitis, particularly ulcerative colitis and nonspecific proctitis.

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“…Collagenous colitis combined with coeliac disease and some degree of villous atrophy has been described in about ten patients [9,12,24,25,47,50]. However, the small number of patients with this combination is in marked contrast with over 200 reported cases of patients with collagenous colitis but without malabsorption and with biopsy-proven normal small gut.…”

Section: Coexisting Immune-related Diseasesmentioning

confidence: 93%

Collagenous, microscopic and lymphocytic colitis. An evolving concept

Bogomoletz

1994

Vichows Archiv A Pathol Anat

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Collagenous colitis and lymphocytic colitis (previously described as microscopic colitis) are two newly recognised forms of colitis. Both have generated much controversy and continue to do so; their aetiology and pathogenesis are unresolved and their association with a variety of immune-related disorders is intriguing. Response to available therapeutic modalities is often disappointing. The possible relationship or overlap between these two conditions remains a controversial issue. The aim of this review is essentially to present an overview of collagenous colitis and lymphocytic colitis and to propose an unifying concept with an adapted terminology.

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Collagenous colitis and coeliac disease.

Cited by 36 publications

References 0 publications

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Histopathological Features of the Terminal Ileum in Lymphocytic and Collagenous Colitis: A Study of 32 Cases and Review of Literature

Nonspecific radiographic abnormalities in collagenous colitis

Collagenous, microscopic and lymphocytic colitis. An evolving concept

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