Collagen sheet dressings for cutaneous lesions of toxic epidermal necrolysis

Abstract

Toxic epidermal necrolysis (TEN) is associated with a significant mortality of 30–50% and long-term sequelae. Treatment includes early admission to a burn unit, where management with precise fluid, electrolyte, protein, and energy supplementation, moderate mechanical ventilation, and expert wound care can be provided. Specific treatment with immunosuppressive drugs or immunoglobulins did not show an improved outcome in most studies and remains controversial. We have treated the cutaneous lesions of seven patients of TEN with collagen sheet dressings and have found a significant reduction in morbidity. The sheets are a one-time dressing, easy to apply and they reduce fluid loss, prevent infection, reduce pain, avoid repeated dressings and gradually peal off as the underlying lesions heal.

A comparative study of collagen granules vs conventional dressing in the management of chronic ulcer

“…7 A Study by S Bhattacharya et al showed excellent results by using Collagen sheets on patients with toxic epidermal necrolysis (TEN). 8 Mason and read demonstrated that microfibrillar collagen triggered adhesiveness of platelets and stimulated the release phenomenon producing aggregation of nearby platelets. 9 Piatkowski et al established that pressure ulcers treated with collagen dressings showed a superior response of healing by having a positive effect on angiogenesis and superior reduction of inflammation.…”

Biological dressing is a paradigm shift in children’s scald burn: our experience

“…Collagen is essential factor in regeneration, it plays a crucial role in cell adhesion , migration and wound healing. [11][12][13][14] Collagen dressing has moderate to high absorption capacity, non adhesive and non hydrating in characteristics. This dressing is beneficial in various ways.…”