Collagen Nerve Wrap for Median Nerve Scarring

Kokkalis, Zinon T.; Mavrogenis, Andreas F.; Ballas, Efstathios G.; Papagelopoulos, Panayiotis J.; Soucacos, Panayotis N.

doi:10.3928/01477447-20150204-04

Cited by 36 publications

(38 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To overcome this problem, collagen materials have recently been developed as an alternative to autologous veins . Vein wrapping was first employed in the upper extremity to avoid scarring in peripheral nerve injury .…”

mentioning

confidence: 99%

“…These studies suggested that collagen materials supplemented with trophic factors may be promising for recurrent compressive neuropathy not amenable to autologous vein wrapping. Collagen materials have since been developed as an alternative to autologous veins and to similarly decrease nerve scarring and improve nerve gliding …”

mentioning

confidence: 99%

“…To overcome this problem, collagen materials have recently been developed as an alternative to autologous veins. 10,11 Vein wrapping was first employed in the upper extremity to avoid scarring in peripheral nerve injury. 3,5,6,8,9 Realization that vein tissue produced several trophic factors that play an important role in the relief of pain was another important milestone.…”

mentioning

confidence: 99%

“…Collagen materials have since been developed as an alternative to autologous veins and to similarly decrease nerve scarring and improve nerve gliding. 10,11 Basic fibroblast growth factor (bFGF) reportedly contributes to the proliferation of undifferentiated Schwann cells and thereby exerts neuroprotective and nerve regeneration effects. [16][17][18] We previously reported that veins used in vein wrapping produced bFGF and relieved pain through induction of heme oxygenase-1 (HO-1) in chronic constriction injury (CCI) sciatic nerve injury model rats.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Wrapping With Basic Fibroblast Growth Factor‐Impregnated Collagen Sheet Reduces Rat Sciatic Nerve Allodynia

Mukai

Uchida

Hirosawa

et al. 2019

Journal Orthopaedic Research

View full text Add to dashboard Cite

Autologous vein wrapping is used to treat recurrent chronic constriction neuropathy and traumatic peripheral nerve injury. However, its use is restricted due to the inability to obtain sufficiently long veins for larger grafts. We previously reported that vein‐derived basic fibroblast growth factor (bFGF) promotes heme oxygenase‐1 (HO‐1), which reduces allodynia via its anti‐inflammatory properties. To mimic vein wrapping, we developed a collagen sheet impregnated with bFGF. Chronic constriction injury (CCI) was induced in male Wistar rats as a model of sciatic nerve injury, and the rats were divided into three groups: (i) untreated after CCI surgery (control group), (ii) treated with a collagen sheet wrap impregnated with phosphate‐buffered saline (PBS/CS group), and (iii) treated with a collagen sheet wrap impregnated with bFGF (bFGF/CS group). Pain behavior (von Frey test) was evaluated on postoperative days (PODs) 1, 5, 7, and 14. Quantitative polymerase chain reaction was conducted on sciatic nerve RNA to quantify HO‐1 gene, Hmox1, expression. Enzyme‐linked immunosorbent assay were used to determine HO‐1 protein levels on POD 1. von Frey testing showed significantly greater pain hypersensitivity in the control and PBS/CS groups than the bFGF/CS group. In the bFGF/CS group, Hmox1 messenger RNA and HO‐1 protein levels were significantly increased in the sciatic nerve compared with the control and PBS/CS groups on PODs 1 and 5 and POD 1, respectively. The bFGF/CS group showed decreased allodynia and HO‐1 induction, as observed with vein wrapping. Therefore, local application of bFGF may be an alternative treatment strategy for compressive neuropathy and peripheral nerve trauma in clinical settings. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2258–2263, 2019

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Wrapping With Basic Fibroblast Growth Factor‐Impregnated Collagen Sheet Reduces Rat Sciatic Nerve Allodynia

Mukai

Uchida

Hirosawa

et al. 2019

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…Collagen nerve wraps maintain nerve mobility following neurolysis. 38,39) All five surgical exposures required neurolysis of the PCBMN. In one patient the nerve was in continuity and neurolysis resolved the problem satisfactorily.…”

Section: )mentioning

confidence: 99%

Iatrogenic Injuries of the Palmar Branch of the Median Nerve Following Volar Plate Fixation of the Distal Radius

Samson

Power

2017

J Hand Surg Asian-Pac Vol

View full text Add to dashboard Cite

Background: Our aims were to identify iatrogenous injuries to the palmar branch of the median nerve sustained during volar plate fixation of the distal radius, make the clinician aware of this relatively uncommon complication of distal radius fixation, to emphasise common threads in symptomatology and to propose an algorithm for evaluation and management. Methods: Retrospectively interrogating our database over a 5 year period, the case records, neurophysiology records, operative records, therapy records were reviewed. The data was analysed with regard to the grade of surgeon performing the procedure, the site of injury, complexity of the fracture, delay to surgery, implant choice and outcome of the treatment. Variations in nerve anatomy were documented during revision surgery and common themes in symptomatology and clinical presentation were identified. Results: Seven patients with an iatrogenic injury involving the palmar branch of the median nerve associated with volar plate fixation of the distal radius were assessed. The male: female ratio was 1:6 and the mean age of patients was 47.8 years (33-74 years). The initial operative fixation was undertaken by a consultant orthopaedic surgeon at a mean of 7.8 (1-17) days from injury. The mean time from fracture fixation surgery to referral to the peripheral nerve injury service was 8.9 (2-36) months. Six patients presented with pain on attempted wrist extension. Five patients had parasthesia, hyperaesthesia or dysaesthesia in the distribution of the PCBMN. Anaesthesia or hypoaesthesia was present in three patients. Two patients presented with symptoms of complex regional pain syndrome (CRPS) Type 2. Conclusions: Revising relevant anatomy and possible variations as well as careful placements of retractors in the region of the median nerve could bring down these injuries. We propose an algorithm for their management.

show abstract

Absorbable versus non-absorbable sutures for skin closure after carpal tunnel decompression surgery

Wade

Wormald

Figus

2018

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

It is uncertain whether absorbable sutures confer better, worse or equivalent outcomes compared to non-absorbable sutures following carpal tunnel decompression, because the quality of evidence is very low. Use of absorbable suture eliminates the need for suture removal, which could confer considerable savings to patients and healthcare providers alike. We need rigorously-performed, non-inferiority randomised trials with economic analyses to inform choice of suture.

show abstract

Collagen Nerve Wrap for Median Nerve Scarring

Cited by 36 publications

References 31 publications

Wrapping With Basic Fibroblast Growth Factor‐Impregnated Collagen Sheet Reduces Rat Sciatic Nerve Allodynia

Wrapping With Basic Fibroblast Growth Factor‐Impregnated Collagen Sheet Reduces Rat Sciatic Nerve Allodynia

Iatrogenic Injuries of the Palmar Branch of the Median Nerve Following Volar Plate Fixation of the Distal Radius

Absorbable versus non-absorbable sutures for skin closure after carpal tunnel decompression surgery

Contact Info

Product

Resources

About