Collagen in Health and Disease

Sandhu, Simarpreet V; Gupta, Shruti; Bansal, Himanta; Singla, Kartesh

doi:10.5005/jp-journals-10026-1032

Cited by 45 publications

(56 citation statements)

References 13 publications

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“…Collagen is the main structural protein in extracellular space in connective tissues in mammals. Collagen is present at high concentrations in the skin, bones, ligaments, cartilage and teeth, and is a particularlyimportant component of the extracellular matrix in fibroblasts ( 24 ). In addition, collagen is associated with the mechanical robustness of skin, resistance of the skin connective tissue, tissue bonding, support of cell adhesion, differentiated function and the induction of cell division ( 23 ).…”

Section: Resultsmentioning

confidence: 99%

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Kim

Jung

Choi

et al. 2015

International Journal of Molecular Medicine

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With the increase in life expectancy, there is also growing interest in anti-aging treatments and technologies. The development of anti-aging functional drugs for the skin, and foods from natural sources, may offer solutions to this global matter. Aging involves structural, functional and biochemical changes that occur throughout cells and bodily tissues; the amount of hormones secreted from of all human organs, including the skin, decreases over time. Matrix metalloproteinase (MMP) genes (MMP-1 and -8) play an important role in the aging of skin fibroblasts. For example, an increased MMP expression causes accelerated aging and the degradation of skin elasticity-related genes. In the present study, we examined the anti-wrinkle effects of tuna heart extract which are mediated through the inhibition of MMPs in skin cells. Generally, tuna contains high concentrations of selenium and antioxidants, which serve to remove free radicals, and is known to delay skin and body aging. In addition, unsaturated fatty acids in tuna help to maintain the natural glossy look of skin, and increase skin elasticity, providing moisture for dry skin. A recent study confirmed the various bio-effects of boiled tuna extract and muscle. However, bioactivity studies using tuna heart are limited. Thus, in the present study, we obtained extracts and fractions of tuna heart, and examined their effects on Hs27 human fibroblast proliferation using an MTS assay. In addition, we measured procollagen type 1 levels and elastase activity, and performed β-galactosidase staining. We then measured the expression levels of phosphatidylinositol 3-kinase/Akt and MMP-related genes by western blot analysis and RT-PCR. Our results revealed that tuna heart extract decreased MMP expression by upregulating tissue inhibitors of metallopro-teinase-1 (TIMP-1) and decreasing elastase activity, thus exerting anti-aging and anti-wrinkle effects by increasing collagen synthesis and promoting skin fibroblast proliferation. Thus, our data suggest that tuna heart (TH)-H2O fractions exert anti-wrinkle effects on Hs27 cells.

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Section: Resultsmentioning

confidence: 99%

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Kim

Jung

Choi

et al. 2015

International Journal of Molecular Medicine

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“…30,31 Meningkatnya serabut kolagen menandakan adanya penyembuhan luka. 32 Membran kulit telur bebek juga terbukti mengandung glikosaminoglikan seperti dermatan sulfat, kondroitin sulfat, glikoprotein sulfat termasuk heksosamin yang terdiri dari glukosamin, asam hialuronat, asam sialik, demosin, isodesmosin, ovotransferin, lysyl oxidase, dan lisozim. Hal ini berperan penting dalam proses penyembuhan luka dengan menunjukkan efek stimulasi pada pembentukan matriks, meningkatkan respon inflamasi, dan memodulasi sintesis asam hialuronat dengan merangsang sintesis matriks ekstraseluler termasuk kolagen pada jaringan dalam proses penyembuhan luka dan anti-inflamasi dengan menekan fungsi neutrofil dan produksi kemokin.…”

Section: Diskusiunclassified

Pengaruh Aplikasi Gel Ekstrak Membran Kulit Telur Bebek 10% Terhadap Kepadatan Serabut Kolagen Pada Proses Penyembuhan Luka Gingiva

Novitasari¹,

Indraswary²,

Pratiwi³

2017

ODONTO : Dental Journal

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Background: Several processes in a teeth treatment often inflict wound in gingiva. Collagen is the key component of the wound healing. The collagen roles in advancing wound healing particularly, triggering the synthesis to induces collagen and cellular migration, and also inducing clotting cascades. Wound treatment using natural product is potential in accelerating wound healing, in particular duck egg membrane which contains collagen, glucosamine, and hyaluronic acid. This study aims to find out the influence of gel extract application of duck egg shell membrane 10 % towards collagen solidity on gingiva wound recovery process (study of Rattus norvegicus). Method: The subjects of the study consist of 20 male Rattus norvegicus aged 2-3 months which were given wound on labial gingiva of the maxillary central incisors with punch biopsy. The samples were divided into 2 groups, they were positive control group (Aloclair Gel

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“…Hypoplasia of enamel, recurrent subluxation of temporomandibular joint has also been reported. [ 32 37 38 39 40 ]…”

Section: Collagen Disordersmentioning

confidence: 99%

“…It is characterized by renal implants, loss of hearing and lens abnormality, hypertension, hematuria and proteinuria. [ 32 ]…”

Section: Collagen Disordersmentioning

confidence: 99%

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Enigmatic insight into collagen

Deshmukh¹,

Dive

Moharil

et al. 2016

J Oral Maxillofac Pathol

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Collagen is a unique, triple helical molecule which forms the major part of extracellular matrix. It is the most abundant protein in the human body, representing 30% of its dry weight. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage and all other connective tissues. Collagens are not only essential for the mechanical resistance and resilience of multicellular organisms, but are also signaling molecules defining cellular shape and behavior. The human body has at least 16 types of collagen, but the most prominent types are I, II and III. Collagens are produced by several cell types and are distinguishable by their molecular compositions, morphologic characteristics, distribution, functions and pathogenesis. This is the major fibrous glycoprotein present in the extracellular matrix and in connective tissue and helps in maintaining the structural integrity of these tissues. It has a triple helical structure. Various studies have proved that mutations that modify folding of the triple helix result in identifiable genetic disorders. Collagen diseases share certain similarities with autoimmune diseases, because autoantibodies specific to each collagen disease are produced. Therefore, this review highlights the role of collagen in normal health and also the disorders associated with structural and functional defects in collagen.

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Collagen in Health and Disease

Cited by 45 publications

References 13 publications

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Anti-wrinkle effects of a tuna heart H2O fraction on Hs27 human fibroblasts

Pengaruh Aplikasi Gel Ekstrak Membran Kulit Telur Bebek 10% Terhadap Kepadatan Serabut Kolagen Pada Proses Penyembuhan Luka Gingiva

Enigmatic insight into collagen

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